tRNA dosage regulates lineage dependency and resistance in prostate cancer - Nature

A tRNA-specific regulatory pathway is associated with codon biology, lineage transitions and therapy resistance in prostate cancer.

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A preinvasive regulatory T cell axis for lung cancer interception - Nature

An effector regulatory T cell circuit is identified that can be monitored in blood samples to track the development of lung cancer, and blockade of this immune network in the preinvasive setting ...

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Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion - Nature

ZMYND8 suppresses IL-2R–STAT5 signalling by inhibiting p300-mediated transcriptional activation of Il2ra to enforce CD8+ T cell terminal exhaustion, and its deletion boosts effector-lik...

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A design approach for bitopic kinase inhibitors - Nature

Detailed analyses of ligand choice, linkage vector and linker length enabled the development of bitopic inhibitors of ABL1 and EGFR kinases, including an ABL1 inhibitor with enhanced activity aga...

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Hepatocytes promote liver metastasis of pancreatic cancer by providing serine - Nature

Metastatic pancreatic ductal adenocarcinoma (PDAC) in the liver that lack the enzyme necessary to synthesize serine can reprogram hepatocytes to produce this amino acid, thus promoting tumour growth a...

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Identification of broadly tumour-reactive γδ TCRs from multiple myeloma - Nature

A machine-learning algorithm, PreGame, is developed to identify tumour-reactive γδ T cells from single-cell CITE sequencing data, and expansion of this cell population can be used as a biomarker of th...

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Evolution and heterogeneity of lethal metastatic bladder cancer subtypes - Nature

A rapid autopsy programme provides valuable resources to enable detailed molecular and genetic analyses of the temporal evolution of aggressive histological subtypes and therapy resistance in metastat...

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The secret life of a cell-cycle gatekeeper of breast cancer

A newly discovered function for the protein Rb explains why inhibiting cell division can enhance the signalling mediated by the oestrogen receptor that drives breast cancer.

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Biomarkers that predict improved outcomes after perioperative immune-based therapy for lung cancer

Pre-surgical clearance of circulating tumour DNA was associated with benefits when using the immunotherapy nivolumab.

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Biomarkers of nivolumab benefit in resectable non-small cell lung cancer - Nature

Potential predictive biomarkers of perioperative nivolumab therapy benefit in non-small cell lung cancer are identified from evaluable participants in the CheckMate 77T trial.

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Functional role of skull lymphoid structures in CNS immunosurveillance - Nature

Functional lymphoid structures within the skull bone marrow enable central nervous system immunosurveillance and shape immune responses to brain disease.

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Biomarkers of nivolumab benefit in resectable non-small cell lung cancer - Nature

Potential predictive biomarkers of perioperative nivolumab therapy benefit in non-small cell lung cancer are identified from evaluable participants in the CheckMate 77T trial.

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In vivo genome-wide CRISPR screens of human T cells in solid tumours - Nature

An in vivo model that is able to recover human T cells from solid tumours can identify targets to help improve CAR T cell antitumour activity.

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Membranolytic peptide programs immunogenic cell death for cancer therapy - Nature

The synthetic-acid-responsive membranolytic peptide aMPC16-CA50 induces immunogenic membranolytic cell death in tumour cells, robustly potentiating immune checkpoint blockade therapy.

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A tumour-derived organoid biobank maps cancer gene dependencies - Nature

A clinically annotated multi-omic organoid resource with matched tumour samples from 256 patients across 5 cancers maps gene dependencies, reveals subtype-specific vulnerabilities and uncovers treatme...

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A compendium of next-generation patient-derived models for diverse cancers - Nature

The international collaboration of the Human Cancer Models Initiative presents a comprehensive resource of next-generation cancer models from 2,780 donors with 25 cancer types and integrated tumour–mo...

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A dependency map enhanced with next-generation 3D cancer models - Nature

Integration of genome-scale CRISPR screening data from traditional cell lines and next-generation cancer models expands the representation of tumour subtypes and genomic alterations in The Cancer Depe...

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ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer - Nature

The RNA-binding protein ZFP36L2 mediates stress-adaptive plasticity in intestinal regeneration and colorectal cancer metastasis.

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Intestinal stem cells count to eight divisions to maintain cell ratios

In the fly gut, stem cells keep the balance of cell types by undergoing eight rounds of cell division to form absorptive cells, then one round to form secretory cells.

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Intestinal stem cells count self-renewal divisions to switch multipotency - Nature

In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...

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Genetic background sets the trajectory of experimental cancer evolution - Nature

Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...

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Tertiary lymphoid structures harbour stem-like tumour-specific T cells - Nature

Renal cell carcinoma tumours containing tertiary lymphoid structures (TLSs) are enriched for exhausted CD8+ T cells, including tumour-specific clonotypes with stem-like progenitor features and reduced...

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Prior therapy defines mutation profiles in childhood cancer at relapse - Nature

Chemotherapy, particularly with platinum-based drugs, is associated with substantial, rapidly detectable mutagenesis in childhood cancers, tripling private signatures and doubling mutation burden, hig...

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Rare contagious cancer discovered in wild catfish

Transmissible tumours have been found in only a few types of animal, but there might be many more out there.

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Brown bullhead catfish melanoma represents a novel transmissible cancer - Nature

Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer.

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GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma - Nature

Chimeric antigen receptor (CAR) T cells for antitumour therapy ‘armoured’ with a dominant-negative TGFβ receptor II show enhanced efficacy and tolerable safety in patients with advanced...

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Modular in vivo antibody–ADC click to reverse drug resistance in tumours - Nature

In vivo ligation of clinically used therapeutic antibodies via bioorthogonal click chemistry to antibody–drug conjugates leads to enhanced antitumour activity in heterogeneous and treatment-resistant ...

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A high-fat, low-carbohydrate diet can feed intestinal tumours

A ketogenic diet promotes tumour growth in the small intestine in susceptible mice. In people, diet advice might need to be tailored to individual cancer risks.

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Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones - Nature

A combination of different manipulations in mouse models of spontaneous intestinal adenoma formation dissects the roles of systemic and epithelial ketogenesis versus dietary lipids in ketoge...

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