In our new paper, we uncover how Burkholderia switches from antibacterial T6SS-1 to eukaryotic-targeting T6SS-5. Surprisingly, actively turning off T6SS-1 assembly prevents mitochondrial damage and apoptosis. Congrats @christy-chc.bsky.social and the team! link.springer.com/article/10.1...

Regulation of Type VI Secretion Systems of Burkholderia during transition to intracellular lifestyle - EMBO Reports

Pathogenic bacteria tightly regulate gene expression in response to environmental cues. In Burkholderia species, the Type VI Secretion Systems (T6SS) mediate interbacterial competition and host cell i...

link.springer.com

Have a look at our latest review on intracellular P. aeruginosa populations! @basler-lab.bsky.social @biozentrum.unibas.ch @nccr-antiresist.bsky.social

Trends in Microbiology@cp-trendsmicrobiol.bsky.social · 2mo ago

Intracellular Pseudomonas aeruginosa: internalization and survival

Interested in the Function and Regulation of #T6SS? Do you have relevant experience from your Master's project? Apply to this PhD position in our lab: www.biozentrum.unibas.ch/open-positio...

A Garmin watch face with a living microbial battlefield powered by your daily stats that is never the same! 🦠⌚️ The BacFighT6 Watch Face runs a live, #T6SS mediated bacterial simulation on your wrist. apps.garmin.com/apps/eaf881d...

Turn your phone into a bacterial battle ground! 🦠📱 The new BacFighT6 #Android app is both a simulation playground AND a Live Wallpaper. Customize cell parameters, tweak visuals, and watch #T6SS battles evolve right on your home screen! Download here: github.com/BaslerLab/Ba...

New version of BacFighT6! sites.google.com/view/bacfight6 Diffusible toxins produced by prey to impact interactions of Attackers, Defenders and Prey! This can make #T6SS battles interestingly unstable. Like this simulation with no winner after 100k steps: baslerlab.github.io/BacFighT6/in... 👇

Big congrats to @atejadaarranz.bsky.social and co-authors on this paper showing novel insights into the resistance to #T6SS effectors and an unexpected link to antibiotic resistance! Thanks @nccr-antiresist.bsky.social for funding and supporting the collaboration with the Jenal lab! rdcu.be/eShqI

Mechanisms of Pseudomonas aeruginosa resistance to type VI secretion system attacks

Nature Communications - Pseudomonas aeruginosa H1-T6SS delivers effectors in response to exogenous T6SS attacks. In this study, a CRISPRi screen identifies pathways involved in P. aeruginosa...

rdcu.be

Update to BacFighT6, with presets for easy exploration of complex behaviors: sites.google.com/view/bacfight6 Try "battle royale" preset where prey (blue) produce capsule, attackers (red) move towards prey and feed on it, defenders (orange) retaliate! Took a while to eliminate the reds!

Happy to share our latest T6SS review: nature.com/articles/s41... Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!

The type VI secretion system and associated effector proteins - Nature Reviews Microbiology

In this Review, Basler and colleagues examine the type VI secretion system (T6SS), focusing on the diversity of antibacterial T6SS effectors and the evolutionary forces that shape them. They explain h...

nature.com

Major update to BacFighT6: sites.google.com/view/bacfigh... Simulate the role of motility/chemotaxis, capsule production, activation by autoinducers, contact dependent killing, kin-exclusion, foraging and more. Long simulations, extensive data import/export and analysis. Interactive Q&A!

To make our research more approachable, I used #Gemini to develop (mostly by #vibecoding) a simulation of #T6SS mediated bacterial interactions. I hope that you'll have as much fun as I have with this and that you'll learn something new! sites.google.com/view/bacfigh...

Happy to help William with his high school graduation project: inspiration.sjf.ch/the-role-of-... youtu.be/u0d72T9rRQg?... Congratulations! Thanks to @biozentrum.unibas.ch and @nccr-antiresist.bsky.social for support!

The Role of Uncharacterised Genes in the Activity of the Acinetobacter baylyi Type VI Secretion System - Inspiration - Schweizer Jugend forscht

Chemie  |  Biochemie  |  Medizin   William Blättler, 2005 [...]

inspiration.sjf.ch

Poke bacteria with a sharp needle and they poke back in just a few seconds! Congratulations to Mitchell (and others) for this analysis of Pseudomonas #T6SS assembly in response to membrane damage! Collaboration with Rod Lim's lab @biozentrum.unibas.ch www.science.org/doi/10.1126/...

Apply now for the prestigious and independent #BiozentrumPhDFellowships. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until May 18, 2025. bit.ly/4caiqqX @biozentrum.unibas.ch @unibasel.ch #fellowship #PhD #Switzerland #lifesciences