@vdangioE3lab
@vdangioe3lab.bsky.social
The laboratory is investigating the role of ubiquitin system in cancer pathogenesis and response to treatment with ionising radiation.
The Coral Art-Science Consortium is a new initiative dedicated to protecting coral reefs by combining the data and conservation strategies identified by science with the emotional resonance created by art and design. Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/4vm5FlJ
New paper from the @xionglab.bsky.social and Mogessie labs at Yale! We uncover the molecular architecture of mammalian oocyte cytoplasmic lattices (CPLs), revealing GTP-bound tubulin associated with a degradative protein complex. Read the paper: doi.org/10.1038/s415...
Cytoplasmic lattices store developmentally poised degradative and cytoskeletal complexes in mammalian eggs - Nature Structural & Molecular Biology
Li et al. obtain high-resolution, native structures revealing that cytoplasmic lattices in mammalian eggs organize and store degradative and cytoskeletal complexes for early embryonic development.
doi.org
Paulo Ribeiro, @aashikasekar.bsky.social et al @qmbci.bsky.social find that protein phosphatase PP2A activates the Hippo pathway in Drosophila, in addition to its role as a Hippo negative regulator as part of the STRIPAK complex link.springer.com/article/10.1...
PP2A phosphatase regulates Hippo signalling in dual manner - The EMBO Journal
Hippo signalling is an evolutionarily conserved pathway that regulates tissue growth. The FERM domain protein Expanded (Ex) integrates polarity cues to activate the Hippo pathway. Previous work has sh...
link.springer.com
‘Big changes’: Crick to stop paying for hybrid open access. www.researchprofessionalnews.com/rr-news-uk-o...
‘Big changes’: Crick to stop paying for hybrid open access - Research Professional News
Leading biomedical research institute says it will “go full in on green and gold”
researchprofessionalnews.com
Nigel Farage’s Brexit rallies were funded from the EU budget European monies paid for anti-immigrant posters during ‘Say No to EU’ tour archive.fo/DtTsn
Multispecific T-cell engagers attract cancer drug developers nature.com/articles/d41... Multispecific T-cell engagers that bind three or more targets on cancer and immune cells promise to address the shortcomings of their bispecific predecessors
As ministers and the media ponder how to increase spending on defence, Ltd worth reminding ourselves that were it not for the damage Brexit has inflicted on us, we would t be having this conversation. Farage and Johnson have screwed us all.
Mariana Mazzucato has gone viral after calling Brexit “a crime,” arguing that Britain has underinvested by £500 billion compared with OECD averages and that Nigel Farage and Boris Johnson have never really been held accountable.
I won't pay $4,000 for a ticket to see my Knicks play in the NBA Finals for the first time in 27 years, but for some reason I routinely pay three times that much for open access to papers that I wrote myself.
@embopress.org is glad to support the #TrustSeal initiative to become an objective & transparent tool for the community, funders & research assessment to see which of the 35k+ biomed science journals to support. TX for taking the lead @faseborg.bsky.social & biocore.com @embo.org hubs.ly/Q04j1D500
Scientific Societies Launch “Trust Seal” to Strengthen Confidence in Science | Newswise
Scientific societies and scholarly publishing organizations launch the Trust Seal, a new community-led initiative designed to strengthen confidence in science by supporting trustworthy publishing prac...
hubs.ly
Interspecific diversity in the neuronal composition of the mammalian cortex arises from heterochrony in neurogenesis Ikuo Suzuki and coworkers link.springer.com/article/10.1...
Interspecific diversity in the neuronal composition of the mammalian cortex arises from heterochrony in neurogenesis - The EMBO Journal
Mammals share a laminar cerebral cortex, with excitatory neuron subtypes organized in distinct layers. Although this framework is conserved, subtype balance varies markedly between species due to larg...
link.springer.com
One-step generation of T-cell receptor knock-in mice in the TCRβ locus – new methods paper by Angelina Bilate, Johanne Jacobsen and coworkers! link.springer.com/article/10.1...
One-step generation of T-cell receptor knock-in mice in the TCRβ locus - The EMBO Journal
Transgenic mouse models expressing predefined T-cell receptors (TCRs) have been instrumental in advancing our understanding of T-cell biology. However, these traditional models rely on random genomic ...
link.springer.com
For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...
biorxiv.org
Passionate about ubiquitin biology, its mechanistic underpinnings and therapeutic exploitation? We are looking for a PhD student or postdoc to join our team. Applications and informal inquiries welcome! www.mpinat.mpg.de/19-26?c=3895...
PhD student or Postdoc (f/m/d)- Understanding and manipulating ubiquitin ligase specificities -
The research group Ubiquitin Signaling Specificity (Dr. Sonja Lorenz) invites applications for the position as PhD student or Postdoc (f/m/d) – Understanding and manipulating ubiquitin ligase specifi...
mpinat.mpg.de
Doing the periodic cleaning of used plasmid miniprep columns and realized in honor of Earth Day it may be worth reminding you molecular biologists: Plasmid miniprep columns can be cleaned and reused essentially indefinitely! Just add 1 M HCl, soak overnight and wash 3x w/ water. Save $ and plastic
So delighted to have been part of this fantastic collaboration spearheaded by Ngee Kiat 'Jake' Chua (蔡毅杰) and Rebecca Feltham! Congratulations on bringing together so many experts in the field to make such an important resource 🎉 it has been a pleasure! www.sciencedirect.com/science/arti...
The E3-ome gene-centric compendium reveals the human E3 ligase landscape
To define and systematically characterize the human E3 ubiquitin ligase (E3) landscape, we generated the E3-ome, a compendium of E3s encoded by the hu…
sciencedirect.com
Our work on the E3 ligase mechanism of target-directed microRNA degradation is now published! Amazing collaboration with Brenda Schulman’s lab led by @jakobfarnung.bsky.social and @elenaslo.bsky.social, with special thanks to @wyppeter.bsky.social, Lianne Blodgett, and Daniel Lin! tinyurl.com/Z8TDMD
The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation - Nature
Target-directed microRNA degradation is driven by the atypical ZSWIM8–CUL3 E3 ubiquitin ligase that uses a two-RNA-factor authentication mechanism to specifically recognize AGO–miRNA–trigger...
tinyurl.com
David Bartel's Lab@bartellab.bsky.social · 7mo agoWe are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)
The second day of #Biochemistry2026 gets on the way with an exciting talk by Satpal Virdee (@e3chembio.bsky.social). "Next-generation Activity-Based Probes for Ubiquitin and Ubiquitin-like E3 Ligases". www.nature.com/articles/nch... #ChemBio #Biochemistry #ChemSky #ubiquitin #TPD #degradation
Paused MRC funding calls to restart earlier than expected. Applicant-led calls to reopen on 7 April, as research council overhauls grant review structure. www.researchprofessionalnews.com/rr-news-uk-r...
Paused MRC funding calls to restart earlier than expected - Research Professional News
Applicant-led calls to reopen on 7 April, as research council overhauls grant review structure
researchprofessionalnews.com
Many genome-editing tools work by cutting DNA - but the shape of the cut matters. Using genome-wide screening, we show ERCC6L2 is specifically required to maintain repair fidelity at staggered DNA breaks, but not at blunt ends. www.nature.com/articles/s41...
UK university unions demand pay rise 3% above inflation Employers describe claim as “extremely challenging” in current financial climate www.researchprofessionalnews.com/rr-news-uk-u...
UK university unions demand pay rise 3% above inflation - Research Professional News
Employers describe claim as “extremely challenging” in current financial climate
researchprofessionalnews.com
Elsevier rejections: libraries ‘had to make cuts somewhere’. Experts say publisher’s pricing and profits are likely factors in rejection by some universities. www.researchprofessionalnews.com/rr-news-uk-o...
Redundancies at research-intensive universities double in two years. www.researchprofessionalnews.com/rr-news-uk-u...
Job losses at research-intensive universities double in two years - Research Professional News
Exclusive: Scale of redundancies revealed by RPN branded a “disaster” for UK research capacity
researchprofessionalnews.com
Another great science appointment is coming up with @centromellone.bsky.social, Michele Pagano and Gergely Róna! Join us live on Tuesday, March 3rd at 5pm (Rome) / 11am (NYC). Zoom link: uniroma1.zoom.us/j/95149984403 Register here to stay in the loop: docs.google.com/forms/d/e/1F...
Job losses at UK research-intensive universities double in two years. Exclusive: Scale of redundancies branded a “disaster”. www.researchprofessionalnews.com/rr-news-uk-u...
Job losses at research-intensive universities double in two years - Research Professional News
Exclusive: Scale of redundancies revealed branded a “disaster” for UK research capacity
researchprofessionalnews.com
DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now 𝐫𝐞𝐩𝐥𝐢-𝐀𝐓𝐀𝐂-𝐬𝐞𝐪 shows 𝘥𝘦 𝘯𝘰𝘷𝘰 chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!
Post-replicative chromatin accessibility predicts cell fate change
Knudsen and colleagues use repli-ATAC-seq to compare replicated and unreplicated chromatin in two models of cell identity change. They find that lineage-specific elements are accessible earlier in rep...
cell.com
