Officially recruiting postdocs at GW. If you are interested in genetic novelty, structural variation, or evo genetics please get in touch! We have data sets on mulitple organisms with large population sizes (Drosophila, Megalonaias nervosa) and species in decline (fireflies, mussels, elephants).

The Rawls Lab is hiring! We are seeking a motivated research technician to support cutting-edge studies in gastrointestinal physiology using zebrafish & mice. To learn more about this hands-on & in-person position at Duke University in Durham NC, click here: careers.duke.edu/job/Durham-R...

Why do intrinsically disordered proteins behave so weirdly during SDS-PAGE? This is the question we aim to answer in our recent paper: onlinelibrary.wiley.com/doi/10.1002/...

Sequence determinants of the hypomobility of intrinsically disordered proteins in <fc>SDS</fc>‐<fc>PAGE</fc>

Proteins with intrinsically disordered regions (IDRs) migrate at a higher apparent molecular weight in sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis, complicating their analysis and...

onlinelibrary.wiley.com

I asked Google's chatbot, Gemini, to help me install & run an RNA structure/sequence analysis program on my Mac. It asked me to paste the sequence for analysis, and it would make the input file. Output looked a little funny… it had deleted one of the 29 nt from the middle of the pasted sequence!

Barack Obama's Confused Reaction

ALT: Barack Obama's Confused Reaction

static.klipy.com

I heard a story about a detained health researcher the other day and assumed this was it - but no, there‘s a second local scientist, from UMD, who is being held by ICE. On his way home from receiving a “teacher of the year” award. www.wbaltv.com/article/umb-...

University of Maryland pharmacy instructor detained in Dallas

Federal officials detained an instructor from the University of Maryland School of Pharmacy last week.

wbaltv.com

Eileen Clancy 🧿@clancyny.bsky.social · 6d ago

Ameaka Fatima Nkempu, a Johns Hopkins University researcher in public health, was detained by ICE while boarding a domestic flight. She says she is Cameroonian in a Medium article that she authored. As of Thursday morning, the ICE Online Detainee Locator did not list where she was being held.

Ameaka Fatima Nkempu, a Johns Hopkins University researcher in public health, was detained by ICE while boarding a domestic flight. She says she is Cameroonian in a Medium article that she authored. As of Thursday morning, the ICE Online Detainee Locator did not list where she was being held.

Baltimore Banner@thebaltimorebanner.com · 6d ago

ICE detains Hopkins public health researcher as agency expands airport arrests

Job alert! I'm recruiting a new post-doc to work on mechanisms of co-translational quality control in the ER. Looking for expertise in ribosome biology and yeast genetics/cell biology. Please reach out to me with any questions. www.dundee.ac.uk/work-for-us/...

Postdoctoral Research Assistant - UOD2336

Closing date: Thursday 27 August 2026, 23:59

dundee.ac.uk

We’re so excited to share our new paper, where we tackle the wealth of structural and functional diversity of anti-phage sensors across bacteria (1/6)

Nature@nature.com · last wk.

Nature research paper: Diverse bacterial pattern recognition receptors sense the core phage proteome go.nature.com/45fpXCZ

RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...

Analog intrinsic recoding measures RNA dynamics without chemical conversion

Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...

biorxiv.org

Few statisticians know that Frank Yates, pioneer of experimental design, is responsible for the annoying practice of indicating 3 tiers of statistical significance by stars (*p ≤ 0.05, **p ≤0.01, ***p ≤ 0.001). He soon regretted it and “vehemently opposed its unthinking use”. And here we are.

Our lab at Pitt is looking to hire a technician. Ideal candidate would be a recent graduate with some cell biology skills, looking to expand their experience before applying to a PhD program in a couple of years. If you are this person, interested in DNA replication, please email me. moiseevalab.com

Any known examples of an RNA localization element in the 5’UTR?

1/10 🚨Preprint! One RING to rule them all (phages)👑💍⚔️ Bacteria build giant DNA-scaffolded RNase rings (larger than the ribosome!) to shut down viral infection🧬🧵👇 biorxiv.org/content/10.6...

Join us in a fun, crazy and interesting interdisciplinary research project that combines protein biophysics, evolutionary genomics, biomolecular archaeology, and textile research to resolve species identity and post-translational modifications in the structural proteins collagen and keratin

Matthew Collins@matthewcollins.bsky.social · 3w ago

Copenhagen job alert 🚨 GLOBE (@ucph.bsky.social) is hiring a 21-mo Postdoc in #Bioinformatics & #ComputationalProteomics Work with @lindorfflarsen.bsky.social, @fridowelker.bsky.social, @brandtgroup.bsky.social & more mapping collagen/keratin diversity across 1000s of genomes. 📅 Deadline Aug 31

New paper from the @xionglab.bsky.social and Mogessie labs at Yale! We uncover the molecular architecture of mammalian oocyte cytoplasmic lattices (CPLs), revealing GTP-bound tubulin associated with a degradative protein complex. Read the paper: doi.org/10.1038/s415...

Cytoplasmic lattices store developmentally poised degradative and cytoskeletal complexes in mammalian eggs - Nature Structural & Molecular Biology

Li et al. obtain high-resolution, native structures revealing that cytoplasmic lattices in mammalian eggs organize and store degradative and cytoskeletal complexes for early embryonic development.

doi.org

Note septins at play here! www.biorxiv.org/content/10.6...

Atonosomes, compartments involved in membrane tension decrease

To ensure survival, cells need to buffer the effects of environmental stress on their plasma membrane, yet the structural mechanisms by which this is acutely achieved remain largely unknown. Here, we ...

biorxiv.org

A tenure-track research position is available for application at the Westerdijk Fungal Biodiversity Institute @westerdijkinst.bsky.social located in Utrecht Science Park in the Netherlands. Please share with colleagues and see the link below for more info: wi.knaw.nl/news/details...

“Flex fuel” helicases 💯 www.nature.com/articles/s41...

ATP is dispensable for E. coli DNA replication and eukaryotic helicase activity - Nature Communications

Here the authors show that replicative helicases from bacteria to humans can use dTTP instead of ATP for DNA unwinding, and that the E. coli replisome preferentially uses dTTP during DNA replication, ...

nature.com

The Kaplan Lab at the University of Pittsburgh has received funds to recruit a postdoctoral fellow to establish a multiplexed assay of variant effect for a disease gene. This relates to our studies on RNA Polymerase II. This project requires experience with human cell lines and genomics 1/

Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences. Our @nature.com article demonstrates that these predictions miss thousands of protein sequences present in human tissues. www.nature.com/articles/s41... 1/

Nikolai Slavov@slavov-n.bsky.social · 2y ago

We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. www.biorxiv.org/content/10.1...

1/ Mitochondrial Na⁺ links metabolism, Ca2+ signaling and disease. We know how it gets in, how it gets out, and proteins that use it. But: we've never actually seen Na⁺ in single mitochondria in live cells. We started with an unusual observation, went down a rabbit hole & found some cool biology .

Our new paper was, by definition, an adventure: stepping outside of our comfort zone, embracing the unknown, and engaging in activities where the outcome is uncertain. Includes discovery of a new species and working with a Native American tribe to name it… 🧵👇 onlinelibrary.wiley.com/doi/10.1002/...

Comparative Analysis of Stress Adaptation in the Yeast Microbiome of Cactus

Yeasts and related fungi isolated from cacti or nearby non-cactus plants were characterized phenotypically and genomically, revealing differences that hint at modes of adaptation to the cactus host.

onlinelibrary.wiley.com

It's great that buffering by chaperones like Hsp90s continues to be studied as "capacitors of evolution". I hope at some point the concept catches on that chaperones can also protect against harmful mutant proteins by kinetically trapping them so they can't poison protein complexes (PMID 25673805)

Nature@nature.com · 2mo ago

Our genomes are full of mutations that have the potential to damage our health or even kill us. Yet most of them rarely cause problems. Why? go.nature.com/4w0pUGl

Our newest review on septins as makers & breakers of membrane contacts in J Neurochem Fun writing with new PhD grad (and FASEB Septin Conference A/V Assistant Extrordinaire) TJ Holt Thanks @mcmurraylab.bsky.social @sergemostowylab.bsky.social for input. onlinelibrary.wiley.com/doi/10.1111/...

Septins in the Middle—Makers and Breakers of Membrane Contact Sites

Septins are a family of GTP-binding proteins that assemble into heteromeric oligomers and polymers, associating with specific membrane domains and organelles according to their subunit composition. G...

onlinelibrary.wiley.com

Sad that the university has decided to shut down the 900 MHz NMR in part because Trump’s illegal war has made helium supplies unpredictable and likely unaffordable. Don’t think I’ll ever get a chance to use its ilk again. #ChemSky 🧪

Now they want to meet with me in person to discuss... feel free to comment here with talking points I should include!

MichaelMcMurray lab@mcmurraylab.bsky.social · 2mo ago

Just sent this to ThermoFisher via our local rep. Hope it’s ok to use your words, Magnus! They are spot-on

Congratulations to Gautam Dey (EMBL) and Omaya Dudin (University of Geneva) for being awarded the EMBO Gold Medal 2026 in recognition of their outstanding contributions to the #LifeSciences in Europe! 🧪 https://www.embo.org/press-releases/embo-gold-medal-2026-awarded-to-gautam-dey-and-omaya-dudin/

Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...

mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity

Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.

cell.com

Megathread resources now compiled in a Google doc. Send it to your friends. Share with your departments and trainees. And share with non-scientists! I also have a template for non-scientist comments, because this is an all-taxpayer, all medical service user issue. docs.google.com/document/d/1...

Submit an OMB Comment!

SAVE AMERICAN SCIENCE (Please! 💜 Annika @annikabarber.bsky.social) What are the proposed changes to scientific grant review and award? Read the Federal Register directly here: Regulation for Federal...

docs.google.com

Annika Barber@annikabarber.bsky.social · 2mo ago

Megathread about responding to new OMB grant funding rules (feel free to add/link more!) I was collecting these for me, but figured I'd round 'em up for everyone 🧪 What's the problem? arstechnica.com/science/2026... elizabethginexi.substack.com/p/summary-of...

Thermo Fisher now has a page up in response to our observations. They flatly deny that images were manipulated or fabricated while repeating that images were "optimized for presentation and clarity on the website", no lie, six times. www.thermofisher.com/us/en/home/l...

Reese Richardson@reeserichardson.bsky.social · 2mo ago

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)