So delighted to have been part of this fantastic collaboration spearheaded by Ngee Kiat 'Jake' Chua (蔡毅杰) and Rebecca Feltham! Congratulations on bringing together so many experts in the field to make such an important resource 🎉 it has been a pleasure! www.sciencedirect.com/science/arti...

The E3-ome gene-centric compendium reveals the human E3 ligase landscape

To define and systematically characterize the human E3 ubiquitin ligase (E3) landscape, we generated the E3-ome, a compendium of E3s encoded by the hu…

sciencedirect.com

Heatwave in London as seen from the Crick’s roof terrace at lunchtime ☀️

Do you want to hear more about ubiquitin? Are you free on Friday 14:00 BST? If so, why not join the Biochemical Society early career researcher webinar series where my fellow UCL alumnus Michele Frison and I will be presenting! 💻 💡 Registration: register.gotowebinar.com/register/821...

Fascinating and diverse programme of talks at the joint Autophagy UK and @ukproteostasis.bsky.social meeting in Dundee this week! & super happy to have the chance share our #pseudoligase work 📣

After a great review process with @naturecomms.bsky.social, I'm so happy to share our work identifying inactive RING E3 #ubiquitin #pseudoligases in the TRIM protein family!! rdcu.be/ehlGW 🥳 🍾 🙌 @katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk

Identification of RING E3 pseudoligases in the TRIM protein family

Nature Communications - Understanding the catalytic and regulatory mechanisms of the ubiquitin system is key to tapping into its therapeutic potential in diseases where its dysfunction is...

rdcu.be

Well put! theguardian.com/commentisfre...

As a geneticist, I will not mourn 23andMe and its jumble of useless health information | Adam Rutherford

Millions paid to give away their most personal data. At least in return they found out more about their earwax, says academic and author Adam Rutherford

theguardian.com

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes. rdcu.be/edRwF

Autophagy UK & Proteostasis UK joint meeting -June 3-5. Exploring the lifecycle of cellular components from synthesis to degradation. Going to be a great meeting and we look forward to welcoming you to Dundee! Exciting lineup of speakers and opportunities for ECRs Register here: tinyurl.com/mr3p49f9

Joint 2025 Autophagy UK and Proteostasis UK conference | University of Dundee, UK

Welcome to the 2025 joint “Autophagy UK and Proteostasis UK” conference!

tinyurl.com

Really enjoying kicking off the week with this new, excellently-written review on #ubiquitin from a structural perspective - so useful to step back every now and again and get an eagle's eye view on the field! www.cell.com/molecular-ce...

Ubiquitin—A structural perspective

Ubiquitin is a cellular modification that comes in many forms. In this review, Agrata and Komander analyze the 240 available PDB structures of ubiquitin and polyubiquitin, alongside ensemble and molec...

cell.com

Mixing a leaving party with our Christmas party; house music with high res imaging… #Crickmas @crick.ac.uk

Christmas is looking very jolly here at the Crick! @thecrick.bsky.social 🎄✨ takes the edge off early starts with such short daylight hours…

CONFIRMED: Oxford University Press select 'brain rot' as the 2024 Oxford Word of the Year 🧠📱 #OxfordWOTY