We already knew that severe acute #COVID19 is induced by pathogenic IgG. But now Lynn Mes & @oliverch77.bsky.social show in @eurjimmunol.bsky.social that IgA2 adds even more fuel to the fire 🔥: onlinelibrary.wiley.com/doi/10.1002/...
Anti‐SARS‐CoV‐2 Spike IgA2 Induces Inflammation by Human Macrophages
Anti-SARS-CoV-2 spike IgA drives inflammation in human macrophages through FcαRI-Syk signaling. IgA2 immune complexes amplify cytokine production and alter glycolysis and mitochondrial function more ....
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