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Dr. Jeroen den Dunnen

@drdendunnen.bsky.social

Immunologist and Head of Department of CIMM at the Amsterdam UMC, Netherlands. My team studies the role of antibodies during infection and autoimmune diseases, with a particular focus on post-acute infection syndromes (PAIS), such as Long-COVID and ME/CFS.

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Dr. Jeroen den Dunnen@drdendunnen.bsky.social · 4mo ago

Our paper is (finally) out in @cp-cellrepmed.bsky.social: antibodies from #LongCOVID patients transfer symptoms to mice, pointing to a potential causal role for autoimmunity: www.cell.com/cell-reports... @amsterdamumc.bsky.social @umcutrecht.bsky.social 1/12

Transfer of IgG from long COVID patients induces symptomology in mice

Chen et al. show that long COVID IgG induces pain-associated behaviours in mice. Pathogenic IgG effects vary across biomarker-defined subgroups, which exhibit specific, long-lasting autoantibody signa...

cell.com

Eric Topol@erictopol.bsky.social · 4mo ago

Transferring IgG antibodies from patients with #LongCovid to mice recapitulates many symptoms www.sciencedirect.com/science/arti...

Dr. Jeroen den Dunnen@drdendunnen.bsky.social · 5mo ago

For the first time, a prestigious Dutch #VICI grant (€ 1.5M) has been awarded to research on post-acute infection syndromes (PAIS). I’m deeply grateful for this opportunity to further indentify the underlying mechanisms: www.zonmw.nl/en/news/39-r...

39 researchers receive Vici grant

What is the welfare wall and why do we encounter it? How do lightning fires threaten permafrost soils? What do we know about restoring disrupted communication b

zonmw.nl

Dr. Jeroen den Dunnen@drdendunnen.bsky.social · 10mo ago

We already knew that severe acute #COVID19 is induced by pathogenic IgG. But now Lynn Mes & @oliverch77.bsky.social show in @eurjimmunol.bsky.social that IgA2 adds even more fuel to the fire 🔥: onlinelibrary.wiley.com/doi/10.1002/...

Anti‐SARS‐CoV‐2 Spike IgA2 Induces Inflammation by Human Macrophages

Anti-SARS-CoV-2 spike IgA drives inflammation in human macrophages through FcαRI-Syk signaling. IgA2 immune complexes amplify cytokine production and alter glycolysis and mitochondrial function more ....

onlinelibrary.wiley.com

Dr. Jeroen den Dunnen@drdendunnen.bsky.social · 11mo ago

Long COVID patients show immunological imprinting and impaired antibody class switching: fewer IgG/IgA antibodies against SARS-CoV-2 spike, but more against seasonal coronaviruses. Interesting finding by my PhD student Ashwin Mak in J Med Virol: onlinelibrary.wiley.com/doi/10.1002/... 1/6

Seasonal Coronavirus‐Induced Immunological Imprinting and Previous Herpesvirus Infections in Patients With Long COVID

Long COVID (LC) is a post-acute infection syndrome affecting 5%–10% of individuals infected by SARS-CoV-2. Here, we aimed to study SARS-CoV-2 humoral immunity, immunological imprinting by endemic cor...

onlinelibrary.wiley.com

Dr. Jeroen den Dunnen@drdendunnen.bsky.social · last yr.

My team is very much looking forward to join the @keystonesymposia.bsky.social on #LongCovid and other PAIS (2 talks, 3 posters). Organized by @virusesimmunity.bsky.social @ahandvanish.bsky.social on Aug 10-13 2025 in Santa Fe: www.keystonesymposia.org/conferences/...

Long COVID and Other Post-Acute Infection Syndromes | Keystone Symposia

Join us at the Keystone Symposia on Long COVID and Other Post-Acute Infection Syndromes, August 2025, in Santa Fe, with field leaders!

keystonesymposia.org

Dr. Jeroen den Dunnen@drdendunnen.bsky.social · last yr.

I’m really impressed by the high level of research that was presented at the International ME/CFS Conference 2025 #mecfsconference, organized by the great @scheibenbogen.bsky.social: events.mecfs-research.org/en/events/co.... I’ll mention a few (personal) highlights: 1/7

ME/CFS Research Foundation

ME/CFS Research Foundation is a non-profit organization dedicated to advancing research and understanding of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome.

events.mecfs-research.org