The Power of Expectations
@sfb-trr-289.bsky.social
SFB/TRR 289, a transregional collaborative research center on the role of patients’ treatment expectations Joint work of @unidue.bsky.social, @uni-hamburg.de & @unimarburg.bsky.social Speaker @ulrikebingel.bsky.social https://treatment-expectation.de
Important work led by one of our PIs, @sheddenmora.bsky.social! 🤩 This study investigated psychological determinants of pregnancy-related symptom burden in 347 women. Read it here: doi.org/10.1038/s415...
Expectations predict early pregnancy-related symptom burden - Scientific Reports
Scientific Reports - Expectations predict early pregnancy-related symptom burden
doi.org
⏰ New preprint ⏰ "Layer-specific cortical processing dissociates sensory and cognitive influences on pain" www.biorxiv.org/content/10.6... Collab w. @elh-institute.bsky.social, @tspisak.bsky.social, @ulrikebingel.bsky.social and some people not on here 😍
All the details are in the thread, just wanted to say this is really cool work. @sirileknes.bsky.social discussed some her work for a @sfb-trr-289.bsky.social webinar which was fantastic as well ( youtu.be/rRQb2NhDs60?...) bsky.app/profile/siri...
Webinar: Siri Leknes - When and how opioids fail to meet expectations
YouTube video by Die Macht der Erwartungen
youtu.be
Siri Leknes@sirileknes.bsky.social · last wk.Major paper out: A heroic* demonstration that even acute stress increases drug intake in healthy people *4-session 2x2 RCT with ~4 oxycodone injections in 66 volunteers - with repeated blinded 2-panel stress/control inductions (ReSST) 1/🧵 www.nature.com/articles/s44...
Placebo effects are only part of the story. Our new review argues that antidepressant trial outcomes are also influenced by diagnostic uncertainty, illness trajectory, measurement variability, and functional unblinding, with important implications for drug development. doi.org/10.1176/appi...
Determinants of Nonspecific Response to Treatment in Randomized Controlled Trials of Major Depressive Disorder: A Narrative Review | American Journal of Psychiatry
The design, conduct, and interpretation of double-blind randomized placebo-controlled clinical trials in major depressive disorder (MDD) are complicated by determinants of nonspecific response to trea...
doi.org
Tolles Interview mit @ulrikebingel.bsky.social vom Bundesministerium für Forschung, Technologie und Raumfahrt (BMFTR) 🔽 www.gesundheitsforschung-bmftr.de/de/mit-dem-p...
Mit dem Placebo-Effekt wirken viele Behandlungen besser - DLR Gesundheitsforschung
Wie gut eine Therapie wirkt, wird auch durch den Placebo-Effekt beeinflusst. Wie sich dieser beeinflussen lässt und welche Rolle Therapeutinnen und Therapeuten dabei spielen, erläutert Professorin Ulr...
gesundheitsforschung-bmftr.de
1/ Laura Kim, @scheibenbogen.bsky.social and colleagues show that thalamic hyperconnectivity in ME/CFS shifts toward healthy-control patterns after HBOT, most strongly in patients who improve. But what is the thalamus actually computing in this circuit? link.springer.com/article/10.1...
ME/CFS and the thalamus as a precision gate: what reversible thalamocortical connectivity reveals about central gain in post-infectious fatigue - Journal of Translational Medicine
Kim and colleagues report a finding that is easy to understate: thalamic hyperconnectivity with sensorimotor and visuo-occipital cortices, present in patients with myalgic encephalomyelitis/chronic fa...
link.springer.com
Amazing news! Congratulations to Balint! 🍾🥳🍾
The Power of Expectations@sfb-trr-289.bsky.social · 2w ago💐✨ Huge congrats to Dr. Balint Kincses ✨💐 He has received the IFORES Career Kickstart grant for "Layers of pain: uncovering the mechanisms in the cortical integration of bottom-up and top-down processes in pain perception and its modulation using ultra-high field fMRI" @elh-institute.bsky.social
New (German) podcast episode from Paracelsus Lab 🧠 I talk about placebo and nocebo effects, and their role in modern medicine! 👩⚕️🏥⚕️ open.spotify.com/episode/1Cdq... If you like the topic, here are other podcast episodes where I was a guest: open.spotify.com/playlist/51h... @sfb-trr-289.bsky.social
Placebo & Nocebo: Wie Erwartungen Heilung beeinflussen (Dr. Helena Hartmann)
PARACELSUS LAB · Episode
open.spotify.com
Thanks @torwager.bsky.social for this enlightening dispatch in @currentbiology.bsky.social! 🤩 Read it here: www.cell.com/current-biol... And here is the discussed work in @cp-neuron.bsky.social: doi.org/10.1016/j.ne...
A lay summary explains this cool study from @stefaniebrassen.bsky.social et al. 😍 www.clearskyscience.com/en/10.1038/s...
Acute placebo responsiveness predicts longitudinal expectation effects in antidepressant treatment · Clear Sky Science
Study shows that positive treatment expectations can bias emotional perception toward happiness and predict antidepressant outcomes.
clearskyscience.com
The Power of Expectations@sfb-trr-289.bsky.social · 3mo agoAmazing new work from project A06 led by Eun Jin Shim and @stefaniebrassen.bsky.social! 🤩 This study examined whether positive expectations improve outcomes in depressed patients and whether individual placebo responsiveness predicts treatment success 💊 Read it here: www.nature.com/articles/s41...
Great work from one of our CRC members, @astrube.bsky.social!
Trends in Neurosciences@cp-trendsneuro.bsky.social · 2w ago'Brain rhythms of depression: A predictive processing perspective' by Andreas Strube @astrube.bsky.social & Diego Pizzagalli @diegopizzagalli.bsky.social www.cell.com/trends/neuro...
💐✨ Huge congrats to Dr. Balint Kincses ✨💐 He has received the IFORES Career Kickstart grant for "Layers of pain: uncovering the mechanisms in the cortical integration of bottom-up and top-down processes in pain perception and its modulation using ultra-high field fMRI" @elh-institute.bsky.social
More than words: Experience shapes #placebo pain relief through additional brain pathways 🧠 We're excited to share our latest publication in @natcomms.nature.com! 🤩 🔗 Read the paper: rdcu.be/fuxmn #neuroskyence #PsychSciSky #Neuroscience #PainResearch #BrainImaging #TeamScience #Reproducibility
“People interpret numbers in very different ways,” says psychologist @tobikube.bsky.social in the latest episode of our CRC podcast 🎙️👨⚕️ In medicine, it is particularly important to communicate quantities and figures sensitively. Listen now: open.spotify.com/episode/6mC0...
On my way to Cologne!
The Power of Expectations@sfb-trr-289.bsky.social · 3w agoToday, @ulrikebingel.bsky.social, Sven Benson and @helenahartmann.com will be on the #MSWissenschaft for the Meet the Scientist event! Where? Cologne, Mühlheimer Ufer, next to Mühlheimer Brücke When? 10:00 - 15:00 We're looking forward to many questions and discussions! 🤩
For me this is a great way to see how something that was only in my head a few months ago, now travels through Germany on a museum boat! ♥️
The Power of Expectations@sfb-trr-289.bsky.social · 3w agoToday, @ulrikebingel.bsky.social, Sven Benson and @helenahartmann.com will be on the #MSWissenschaft for the Meet the Scientist event! Where? Cologne, Mühlheimer Ufer, next to Mühlheimer Brücke When? 10:00 - 15:00 We're looking forward to many questions and discussions! 🤩
Today, @ulrikebingel.bsky.social, Sven Benson and @helenahartmann.com will be on the #MSWissenschaft for the Meet the Scientist event! Where? Cologne, Mühlheimer Ufer, next to Mühlheimer Brücke When? 10:00 - 15:00 We're looking forward to many questions and discussions! 🤩
Wissenschaft im Dialog@w-i-d.de · 4w agoZum Veranstaltungskalender der MS Wissenschaft: ms-wissenschaft.de/de/veranstal... @sfb-trr-289.bsky.social @dfg.de
Very happy to see this Review with @diegopizzagalli.bsky.social out in @cp-trendsneuro.bsky.social www.cell.com/trends/neuro... This piece brings together a lot of what we’ve been thinking on depression, predictive processing and EEG. Many thanks for the support from @sfb-trr-289.bsky.social
Brain rhythms of depression: A predictive processing perspective
Depression is marked by anhedonia, social withdrawal, and a diminished capacity to learn from positive experiences—features that can be framed within predictive processing. Here, we review findings fr...
cell.com
Wir sind auf der #MSWissenschaft mit unserer Veranstaltung „Die Kraft der Erwartung – Wie geht gute Kommunikation in der Medizin?“ ➡️ Wann? Dienstag, 7. Juli 2026, 15:30 bis 17 Uhr ➡️ Wo? Duisburger Innenhafen am Kultur- und Stadthistorischen Museum ➡️ Der Eintritt ist frei, Anmeldung nicht nötig.
Another philosophical paper with a very interesting perspective on expectations and their role in transformative experiences. Especially tackles the issue of having expectations about a completely novel experience. Might be of interest to @sfb-trr-289.bsky.social www.tandfonline.com/doi/full/10....
The role of expectations in transformative experiences
According to L. A. Paul, the subjective value of an outcome is normally assessed by running a cognitive model of what it would be like if that outcome were to occur. However, cognitive models, alon...
tandfonline.com
Vom Sonderforschungsbereich Treatment Expectation @sfb-trr-289.bsky.social wurde ich dazu interviewt, warum unser Gehirn wie eine Vorhersagemaschine ist - und wie Erwartungen unsere Wahrnehmung und unser Schmerzempfinden verändern können. Und was das für Jugendpsychiatrie bedeutet. Hier der Link:👇
Wieviel bringt teure Ausrüstung eigentlich wirklich? ELH-PI und Placebo-Expertin @ulrikebingel.bsky.social im Podcast bei RTL+ über effektives Training und die Frage, wie sehr Erwartung unsere Leistung beeinflusst: plus.rtl.de/achilles-run...
In case you missed it, we have a bilingual video series called 🥜 "In a nutshell" 🥜 In this series, our scientists explain what their work has to do with expectations, what new research found, & what patients can do to feel better. Here they are all in a thread for you to browse & watch! ⤵️
Jason Bateman: In A Nutshell
ALT: Jason Bateman: In A Nutshell
static.klipy.com
♥️ You have to celebrate ALL the victories! ♥️ Today, after 114 testing sessions, Team Empathy from the Bingellab celebrated the finished data collection of Julia Braunstein's study with lots of ice cream! 🍨
The last few weeks were full of great new work from our CRC, so here are the ones we haven't posted about yet! 😍
Back to Work Cat Animation
ALT: Back to Work Cat Animation
static.klipy.com
Great and relevant work for the overlapping fields of psychedelic research and the science of treatment expectations (@sfb-trr-289.bsky.social). Interestingly the extracted dimensions map quite well on the TEX-Q measure of treatment expectations! onlinelibrary.wiley.com/doi/10.1002/...
Expectations and Motivations for Participation in Clinical Trials Utilizing Psychedelics for Treatment‐Resistant Depression: A Qualitative Study
Individuals with treatment-resistant depression considering psychedelic trial participation were motivated by chronic illness, failed treatments, and hope for a novel intervention, while actively min....
onlinelibrary.wiley.com
While we're talking about podcasts... @ulrikebingel.bsky.social talked to the folks at ACHILLES RUNNING how to use placebo effects during running training 🏃 Watch/listen (in German): www.youtube.com/watch?v=hFEc...
Placebo-Effekte im Training nutzen - mit Prof. Dr. Ulrike Bingel | ACHILLES RUNNING Podcast
YouTube video by ACHILLES RUNNING
youtube.com
Damit PatientInnen medizinische Sachverhalte verstehen, sollten Behandelnde komplizierte Fachsprache vermeiden 😵💫 Gleichzeitig müssen sie präzise, korrekt & medizinisch zutreffend kommunizieren 🤷♀️ Wir sprechen dazu mit Dr. med. Anja Bittner in einer neuen Folge. ▶️ open.spotify.com/episode/65hS...
We need a few more people, please consider participating in this very short study - you can also win something! 😁
Dr. Helena Hartmann (she/her)@helenahartmann.com · 2mo agoIm Rahmen einer Bachelorarbeit untersuchen wir, wie unterschiedliche Schreibstile das Textverständnis beeinflussen 🔤 Die Teilnahme an der Studie ist anonym und dauert nur wenige Minuten. Es werden vier 20 € Amazon-Gutscheine verlost bzw. 0,5 VP-Stunden vergeben. ➡️ s2survey.net/Wissensfrage...
Today and tomorrow we have a few posters from the CRC at #OHBM2026! 🧠 ▶️ #2066 from Jialin Li on "Beyond pain: a brain-based signature predicts individual pain relief" ▶️ #2234 from @ggallitto.bsky.social on "External validation of machine-learning models - registered models & adaptive splitting"
The Organization for Human Brain Mapping@ohbmofficial.bsky.social · 2mo agoJoin us for the #OHBM2026 Poster Reception! 🧠🤝 📅 June 16 🕓 17:00–18:00 📍 Exhibition Hall 1 Enjoy great science, conversation, and community—see you there! 🔬✨
