The proteostatic environment of gametes is unique. Work just out @natsmb.nature.com from @piotrkolata.bsky.social @a-dsantos.bsky.social @tomdendooven.bsky.social @matteoall.bsky.social is a prime example and sheds light on proteasomes in the human sperm nucleus! www.nature.com/articles/s41...

Molecular architecture and spatial organization of proteasomes in the human sperm nucleus - Nature Structural & Molecular Biology

Proteasomes are essential for male fertility. Kolata, dos Santos, Dendooven and colleagues show large nuclear proteasomal assemblies segregated from DNA in human sperm, forming after meiosis and with ...

nature.com

Ever wondered how the chemotherapeutic drug paclitaxel can target slow-dividing tumours? Check out our preprint Hale et al! @tom-hale.bsky.social found a novel non-mitotic mechanism of action for paclitaxel involving nuclear-cytoskeletal coupling via the LINC complex! www.biorxiv.org/content/10.1...

Ever wondered if nuclear pore architecture and function changes during germ cell differentiation? In human spermatogenesis it does, and radically!! Check out our first lab preprint @AliaCSantos et al! www.biorxiv.org/content/10.1...