Tessera

Well, this is rather wonderful! #IUIS2025

The human immune system evolved over millennia - and can adapt within a single lifetime. This review examines how the immune responses change over the life course. By Jessica Metcalf, Andrea Graham, Andrew Yates and Derek Cummings @science.org buff.ly/GJpPUO7

Tissue immunity meets biological sex differences - context is important in the immune system. Another of my reading recommendations during a trip to @iuis-online.bsky.social Congress. From Sonia Sharma, Alicia Gibbons and Erica Ollmann Saphire in @science.org buff.ly/XPN0Tpb

If you are looking for a great read during your journey to @iuis-online.bsky.social Congress, take a peek at this review from from Matthias Nahrendorf, Florent Ginhoux and @filswirski.bsky.social in @science.org that explores the role of immune cells beyond host defence. buff.ly/S5RkqTf

Anyone traveling to @iuis-online.bsky.social Congress and looking for something to read? Don't miss the reviews from our @science.org Evolving Immunity Special Issue! Here, Kassiotis and Stoye consider endogenous retroviruses and antiviral defences. buff.ly/IU4nbSE

Science Magazine@science.org · 12mo ago

Such a beautiful and intricate image! I was fascinated by the creative process for the cover, and loved getting a behind-the-scenes look at the work of artist Rioka Hayama and the Science Visuals team. Have you guessed all the features yet?

Can you can identify these 10 components featured on our Evolving Immunity special issue cover? 🔎 Drop your guesses in the comments. We’ll reveal the answers next week, so stay tuned! Discover more about the special issue here: https://scim.ag/3JdpWYj

A black and white illustration depicting the changes in the immune system throughout an individual’s life span, from infancy to childhood, adulthood, and older age. There are blank labels 1–10 throughout the illustration.

Seth Thomas Scanlon@immunoeditor.bsky.social · 12mo ago

Not long to go - I'm looking forward to some fantastic immunology!

Heads up: @science.org 's immunology editor @sarahhross.bsky.social and I will both be attending the @iuis-online.bsky.social 19th International Congress next week in the ever enchanting city of #Vienna! We hope to see many of you there!

Science Magazine@science.org · 12mo ago

This week @science.org examines the wonders of the immune system! From molecular defences that co-evolved with pathogens to specialised cells that are intricately linked with physiology, the immune system is attuned to biological sex and different stages of life.

A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health. Learn more: scim.ag/3IYhnk7

This illustration depicts the changes in the immune system throughout an individual’s life span, from infancy to childhood, adulthood, and older age.

#Immunology out now @science.org After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen. buff.ly/49bKcTG By Jobin, Seetharama, Rüttger et al.

#Immunology out now @science.org Regulatory T cells inhibit pain sensing in female, but not male, mice. buff.ly/SKtHnfK By Élora Midavaine, Sakeen Kashem et al.

ICYMI by First release - now in print @science.org Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection. buff.ly/3DjNQ1e By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al

#Immunology by First Release @science.org In mice, during immune responses accompanied by elevated self-antigens, autoreactive CD4 T cells must be restrained by regulatory CD4 T cells with the same antigen specificity to prevent autoimmunity. buff.ly/3EXaXQa

#Immunology out now @science.org Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases. https://buff.ly/3QvxSVf By Maxim Zaslavsky, Erin Craig, @anshulkundaje.bsky.social , @scottboydlab.bsky.social et al.

#Immunology out now @science.org In mice, the transcription factor KLF2 keeps activated CD8 T cells on track to differentiate into functional effector T cells. https://buff.ly/4hBmL8W By Eric Fagerberg, Nikhil Joshi @nikjoshilabyale.bsky.social et al

ICYMI by First Release - now officially in print @science.org Specific combinations of nutrients and metabolic enzymes determine T cell differentiation via loci-specific histone acetylations. https://buff.ly/4gvqKTz From Shixin Ma, Sue Kaech @tcellogic.bsky.social et al. #immunometabolism

Sarah Ross@sarahhross.bsky.social · 2y ago

Not long to go now! Don’t miss out on applying for the NOSTER & @science.org Microbiome Prize! Enter: buff.ly/4gS29ZH More details: ⤵️

If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 years don’t miss out on applying for the NOSTER & @science.org Microbiome Prize! Grand Prize: $25K & your essay published in Science Magazine Deadline: Feb 14th Enter: https://buff.ly/4gS29ZH

This Perspective from Aaron Ver Heul puts the work of Andrew Liu, @danhkaplan.bsky.social et al into context. https://buff.ly/40Bp1G1 #Immunology @science.org

#Immunology out now @science.org Scratching in mice promotes pain-sensing neurons to release a neuropeptide that stimulated antigen-activated mast cells to degranulate and produce inflammatory mediators. https://buff.ly/4hDAgF2 From Andrew Liu, @danhkaplan.bsky.social et al

ICYMI by First Release - now officially in print @science.org Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation. https://buff.ly/3BzpLmL By Andrew MacLean, Michel Nussenzweig et al. #Immunology

#Immunology out now @science.org ILC2s contribute to glucose homeostasis. Neurons that innervate the gut from areas of the brain associated with glucose sensing can stimulate ILC2s in the gut to relocate to the pancreas upon fasting. https://buff.ly/42iBst0

#Immunology by first release now @science.org Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation. https://buff.ly/3BzpLmL By Andrew MacLean, Michel Nussenzweig et al.

#Immunology by First release now @science.org Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection https://buff.ly/3DjNQ1e By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.

#Immunology out now @science.org An unstructured region within MAVS interacts with cellular, rather than viral, RNA. This alters how MAVS interacts with other proteins and influences antiviral responses. https://buff.ly/4grnf18 By @nandangokhale.bsky.social with @ramlabuw.bsky.social et al.

#Immunology out now @science.org Biased antibody responses to influenza strains in vaccines are strongly linked to genetics. Coupling antigens from different strains together may broaden antibody responses. https://buff.ly/4flV5TK By Vamsee Mallajosyula, Mark Davis et al.

I am excited to say, we have not one but FOUR #Immunology Research Articles out this week @science.org! Individual posts to follow!