Lucas Rebiffé

@lucasrebiffe.bsky.social

PhD Candidate at IGFL in Leulier Lab working on nutrition, intestine and microbiota | Lecturer at ENS of Lyon #GutPhysiology #Microbiota #| He/Him

🚨PREPRINT ALERT How different are males and females? In physiology we mostly treat that as a fixed property of a species, something to control for. In mice, we found it is not fixed at all. It depends on what the animal ate while growing up.

Juvenile protein restriction compresses sexual dimorphism in mice

Sexual dimorphism is canonically understood as a fixed adult trait, scaled by gonadal hormones at puberty, but whether its magnitude is shaped earlier in life by juvenile nutrition during the post-wea...

biorxiv.org

Very happy to share this story, where we explored the interaction between GLP-1 signalling and growth! ⬇️ Besides being of scientific interest, it is my very first paper, stepping into the world of physiology ✨

Filipe De Vadder@filipedevadder.bsky.social · last yr.

Our new study, just accepted in the Journal of the Endocrine Society 👉 doi.org/10.1210/jend... We found that semaglutide, beyond its metabolic effects, can exacerbate growth stunting in juvenile mice by reducing energy metabolism, a context-dependent effect of GLP-1 signaling.

1/ 🚨 Excited to share our new study, now published in The Journal of Nutrition! We developed a mouse model of juvenile protein-energy malnutrition (PEM) to assess growth recovery after refeeding with optimal or suboptimal diets. 🧵 www.sciencedirect.com/science/arti...

Suboptimal refeeding compensates stunting in a mouse model of juvenile malnutrition

Early postnatal life is a critical period of rapid growth in mammals, heavily reliant on adequate nutrition. Protein-energy malnutrition (PEM) during …

sciencedirect.com