📣 March Article Award: Congrats to @julienmambu.bsky.social & team! Their Cell paper reveals type III IFNs (IFN-λ) delay gut healing by triggering pyroptosis via ZBP1 → caspase-8 → GSDMC. 🔗https://www.cell.com/cell/abstract/S0092-8674(24)01158-9

Proud to share our work! 🧫😍 A special one! Using Salmonella and Brucella, this study provides the first demonstration of an antibacterial response in pDCs orchestrated by SLAMF7 and SLAMF8, driving cytokine responses and favoring bacterial survival via mtROS control. www.jci.org/articles/vie...

If you want to see our work presented directly from the primary source, @julienmambu.bsky.social will be giving a free webinar on Feb 6th at 5 PM CET as part of the Thursday seminar series of the French Society of Immunology #SFI sign up here: zoom.us/webinar/regi...

#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair

Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.

cell.com

Great to have our study highlighted in @science.org !thanks @smhsci.bsky.social #interferosky

Stella Hurtley@smhsci.bsky.social · 2y ago

And finally (probably) for today, my choice this week in @science.org @lozanzi.bsky.social 10.1016/j.cell.2024.10.010

👨‍🔬🎉Kicking off my bluesky presence by posting our lab's achievement! Our lab's first study is now out in Cell ! We show that IFN-λ induces ZBP1/CASP-8/GSDMC-dependent pyroptosis in gut epithelial cells impairing tissue repair post-colitis.#IBD #Immunology 🧵https://authors.elsevier.com/a/1k2OAL7PXqSL5

#newlabpic with @julienmambu.bsky.social , Amaury, Chloé, Sarah, Magda, Anissa, Franck, Virginie, and Thierno. #blessed

Honored for our research conducted at @ciml.bsky.social is featured in the @cnrs.bsky.social biologie news. Shout out to @julienmambu.bsky.social for the awesome 2D #organoids image. #gastrosky #immunology #interferon www.insb.cnrs.fr/fr/cnrsinfo/...

Nouvelles perspectives thérapeutiques pour les Maladies Inflammatoires Chroniques de l’Intestin

Les Maladies Inflammatoires Chroniques de l’Intestin, ou MICI, touchent plus de 250 000 personnes en France.

insb.cnrs.fr