Excited this multi-year collaboration is in print @NatureGenet with @mspivakov.bsky.social @MalyValerie @HelenR_J Low-input Capture Hi-C reveals promoter-anchored chromosomal interactions in human ILC3 prioritzing CLN3 & other genes as potential ILC3-specific mediators of genetic risk for #IBD

Mikhail Spivakov@mspivakov.bsky.social · yesterday

Very happy to see this story finally out (link in comments)! We used low-input Capture Hi-C to profile promoter-anchored chromosomal interactions in Type 3 innate lymphoid cells (ILC3s) - rare tissue-resident lymphocytes that lack antigen receptors and regulate barrier immunity.

Online now! Online now! Metabolic danger signals: TCA cycle metabolites regulate immunity and disease #chembiol

Metabolic danger signals: TCA cycle metabolites regulate immunity and disease

Ryan and Zanoni redefine TCA cycle metabolites as metabolic danger signals that shape immunity across infections, inflammation, and cancers. They introduce the concept of metabolic DAMPs (“metaDAMPs”) as a unifying framework for understanding immune activities of endogenous metabolites and outline emerging technologies positioning immunometabolism as a tractable axis for therapeutic intervention.

dlvr.it

#ImmunometabolismPower! Excited to share our review @cp-cellchembiol.bsky.social with super-talented @tristramryan.bsky.social about the activity of immunometabolites of the #TCA #Krebs cycle working as metabolic damage-associated molecular patterns #metaDAMPs in health & disease!

Metabolic danger signals: TCA cycle metabolites regulate immunity and disease

Mitochondrial tricarboxylic acid (TCA) cycle metabolites have emerged as critical regulators of immunity and inflammation beyond their canonical metab…

sciencedirect.com

#WeekendRead! #LiveForever! Martini, Adams, Passos &co show @nature.com that mitochondria dysfunction in senescent cells boosts levels of acetyl-CoA rewiring the epigenetic landscape & sustaining #inflammaging which can be reverted by blocking the citrate exporter SLC25A1! doi.org/10.1038/s415...

Mitochondrial metabolism and epigenetic crosstalk drive SASP - Nature

In senescent cells, mitochondria-derived acetyl-CoA promotes histone acetylation and increases chromatin accessibility at inflammatory gene loci. Inhibition of SLC25A1 attenuates these effects, unders...

doi.org

Lot of fun participating to this important initiative @ImmunologyAAI! Lot of passionate attendees/trainees, that asked lot of interesting questions… #Immunology is def in good hands!

The American Association of Immunologists@aai.org · last wk.

In his lecture on “Molecular and Cellular Regulation of Inflammation,” Ivan Zanoni (Harvard Medical School / Boston Children’s Hospital) explained how phagocytes detect virulence factor activity to kickstart inflammation. #AAIcourses

Had so much fun writing this commentary for #msphere! Grateful for the opportunity to write about work that’s shaped my perspective on innate immunity and RNA virus infection journals.asm.org/doi/10.1128/...

mSphere of Influence: Damage in RNA virus infection—a feature or a bug? | mSphere

How does the body recognize viral infection? How do viruses engage the immune system during replication? These seemingly simple questions led me to study pattern recognition, a concept first proposed ...

journals.asm.org

#WeekendRead! #EveryCellIsAnImmuneCell! Jacobs, Bergers &co show @cp-immunity.bsky.social that high endothelial venules #HEVs utilize #autophagy to maintain their identity & recruit immune cells to secondary lymphoid organs during inflammation. Inhibiting autophagy in HEVs protects from #psoriasis!

Autophagy maintains high endothelial venule identity and function during inflammation

High endothelial venules (HEVs) facilitate lymphocyte entry into lymph nodes by displaying peripheral node addressin (PNAd), yet how PNAd is regulated remains poorly understood. Jacobs et al. reveal t...

cell.com

Highly recommend 👇👇👇

Iannacone Lab@iannaconelab.bsky.social · 2w ago

🔬 Recruiting a Physician Scientist PhD student (San Raffaele, Milan) via AIRC-Cariplo-SEMM-UniMi program. Project: reprogramming tumor endothelium to restore anti-tumor immunity in liver cancer. Keep 20% clinical work. Deadline Sept 16. Apply: tinyurl.com/3vcp27dp #AIRC

Must read for #InterferonLovers… & more!! 👇👇👇

MeganStanifer@meganstanifer.bsky.social · 2w ago

Honored to join the inaugural New Voices in Virology cohort at @jvico-eics.bsky.social My minireview digs into the biology of IFNλ — beyond antiviral defense to its tissue-shaping and barrier roles. Now online: doi.org/10.1128/jvi....

Delighted to share an invited review from @labwaggoner.bsky.social written with Anusha Anukanth (Now @upmc.com) in @jimmunol.bsky.social We explore the plethora of functions ascribed to NK cells and what this means for health, disease, and therapy academic.oup.com/jimmunol/art...

#WeekendRead! #LiveForever! Tan, Andreasson &co show @science.org that PGE2 signaling via EP2 in aged tissue resident macrophages prevents neutrophil efferocytosis driving NETs, stromal cell signaling, & inflammaging! Targeting EP2 delays organ aging! doi.org/10.1126/science.aea3075

Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging

Aging disrupts tissue homeostasis across organ systems. Here, we identify tissue-resident macrophages (TRMs) as central coordinators of age-related organ decline through impaired clearance of senescen...

doi.org

Check this out 👇👇👇 Amazing work @cp-immunity.bsky.social by Stephanie, @jkagan1.bsky.social, &co 👇👇👇

Jonathan Kagan@jkagan1.bsky.social · 3w ago

A new PAMP, a new innate immunity principle and a new preclinical application. I am so pleased to share our study on STING activation mechanisms in health and disease. Led by the fantastic Stephanie Ragland, follow the link below for a summary of all we learned. www.cell.com/immunity/ful...

A query: cGAS, STING, AIM2, NODs, NLRs, RLRs: All these PRRs are categorized as pathogen sensors, because they reside in the cytoplasm. In contrast, TLRs sense non-pathogens and pathogens. How confirmed is this dogma, beyond the usual (small) set of pathogens that we all study?

Online now: Nasal immunity in respiratory viral infection, transmission, and protection

Nasal immunity in respiratory viral infection, transmission, and protection

The nasal mucosa is a key decision point during respiratory viral infection. Here, Kazer et al. review new understanding of how local host cell subsets respond during viral infection and how this knowledge may enable tissue-scale protection through mucosal vaccines.

dlvr.it

Friend or foe? IFNλ drives #fibrosis. Ivan Zanoni @lozanzi.bsky.social discusses a new study from Zhou, Zhang et al. (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...

#WeekendRead #EveryCellIsAnImmuneCell #Ironman! Liu, Sun &co show @cellcellpress that #allergens activate PAR1 on lung epithelial cells, elevating intracell levels of iron, leading to protease-independent GSDMD cleavage & release of pro-allergic IL33 & ILC2 activation! www.cell.com/cell/abstrac...

Iron drives protease-independent cleavage of gasdermin D in allergic airway diseases

Allergen exposure activates gasdermin D in lung epithelial cells through an iron-mediated, protease-independent mechanism requiring the PAR1-ferritinophagy-PCBP2 axis. This unconventional cleavage dri...

cell.com

Helpful form to help craft comment for submission regarding OMB rules, deadline July 13!!

Tara C. Smith@aetiology.bsky.social · 4w ago

This can help you get started if it all seems intimidating.

#JoinUs & present your #science!! Exciting #free satellite meeting just after #Cytokines2026 @cytokinesociety.bsky.social 👇👇👇

Achille Broggi🧪👨🏼‍🔬🔬@achillebro.bsky.social · last mo.

Which is the best #IFN, and why is it IFN-λ? If you are also interested in this amazing #cytokine, and you're planning to attend the @cytokinesociety.bsky.social meeting in Glasgow this fall, we have you covered with a #free satellite workshop on the 22nd of october. ifnlworkshop.org

Excited to share this “Insight” @jem.org about an amazing new finding by Zhou, Zhang, Ye, Staeheli &co showing that type III interferons #IFNL also signal in #fibroblasts driving renal #fibrosis! #InterferonPower! #EveryCellIsAnImmuneCell! #FriendsOrFoes!

Journal of Experimental Medicine@jem.org · last mo.

IFNλ works at mucosal surfaces by signaling in epithelial cells and selected immune cells. Zhou, Zhang et al. (rupress.org/jem/article/...) demonstrate that IFNλ also signals in kidney fibroblasts sustaining renal #fibrosis. @lozanzi.bsky.social highlights the findings: rupress.org/jem/article/...

#WeekendRead! #DoNotStress! #EveryCellIsAnImmuneCell! Bashir Zeng &co show @cp-cancercell.bsky.social that gut leakage due to chronic stress-induced steroids leads to translocation of an enterococcus to tumors, driving corticosterone by cancer-associated fibroblasts to inhibit anti-tumor B cells!

Chronic stress unleashes an intratumor phage-fibroblast-B cell circuit to promote tumor growth

Chronic stress disrupts the gut microbiota in patients with cancer; however, how stress-induced microbiota perturbations impact anti-tumor immunity re…

sciencedirect.com

#WeekendRead! #MomIsAlwaysMom! Fan Zheng Chen &co show @science.org that a maternal diet-derived fatty acid contained in breast milk potentiates Th1 responses in newborns protecting against bacteria & viruses throughout adulthood! doi.org/10.1126/scie...

Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting

How maternal nutrition influences neonatal immune development and imprinting through breastfeeding remains largely unclear. We report that maternal supplementation with trans-vaccenic acid (TVA), the ...

doi.org

Maybe the lambda symbol for the workshop needs a Scottish update? (Via ChatGPT) 😀😀

Would love to see fellow #IFNL enthusiasts in Scotland🏴󠁧󠁢󠁳󠁣󠁴󠁿 in October! Abstract submission is due early July and is separate from #Cytokines2026. 1 day free add on so register and submit an abstract soon 👇👇👇 Thanks @achillebro.bsky.social Rune and Charlotte for the talk invitation 😀 #BestIFN

Achille Broggi🧪👨🏼‍🔬🔬@achillebro.bsky.social · last mo.

Which is the best #IFN, and why is it IFN-λ? If you are also interested in this amazing #cytokine, and you're planning to attend the @cytokinesociety.bsky.social meeting in Glasgow this fall, we have you covered with a #free satellite workshop on the 22nd of october. ifnlworkshop.org

#JoinUs & present your #science!! Exciting #free satellite meeting just after #Cytokines2026 @cytokinesociety.bsky.social 👇👇👇

Achille Broggi🧪👨🏼‍🔬🔬@achillebro.bsky.social · last mo.

Which is the best #IFN, and why is it IFN-λ? If you are also interested in this amazing #cytokine, and you're planning to attend the @cytokinesociety.bsky.social meeting in Glasgow this fall, we have you covered with a #free satellite workshop on the 22nd of october. ifnlworkshop.org

The purpose of this workshop is to promote research on in IFN-λ, foster collaborations, and bring the community together. Please share this as broadly as possible and join us for this #IFNLWorkshop2026

We invited outstanding speakers @drdeannasanter.bsky.social nasanter.bsky.social Vangelis Andreakos, Andreas Wack, @hemannlab.bsky.social @lozanzi.bsky.social , but we need you to submit your #abstract and present new and exciting science!

#WeekendRead! #ImmunometabolismPower! Choi, Biswas &co show @cp-cellhostmicrobe.bsky.social that upon Candida-driven glucose deprivation in tissues, neutrophils boost glycogenesis via Dectin-1 to maintain anti-fungal #ROS & neutrophil extracellular traps #NETs, protecting against candidiasis!

Glycogen phosphorylase L confers metabolic flexibility in neutrophils to fight fungal infections in nutrient-deprived tissues

Neutrophils depend on glucose for their antifungal activities. Candida albicans consumes glucose, thus posing metabolic challenges for neutrophils. Choi and colleagues show that neutrophils upregulate...

cell.com

#WeekendRead! #MicrobiotaPower! #EveryCellIsAnImmuneCell! Sakamachi, Garantziotis &co show @ Science Translational Medicine @science.org that upon #lung damage, #microbiota sensing via #TLR5 by lung #epithelial cells protects from dysbiosis preventing pulmonary fibrosis! doi.org/10.1126/scit...

Toll-like receptor 5 protects against murine lung fibrosis through reduced dysbiosis, and TLR5 deficiency is associated with human IPF

TLR5 deficiency is associated with idiopathic pulmonary fibrosis, and TLR5 activation reduces lung dysbiosis and protects against fibrosis in mice.

doi.org

Wow! 🤯👇👇👇👇

Cell - a Cell Press journal@cp-cell.bsky.social · 2mo ago

Now online! Long-term reversal of Duchenne muscular dystrophy via circular arRNA-guided exon skipping in monkeys and humans

A decade ago we showed that T-dependent IgM+ memory B cells (MBCs) that express CD80 and CD73 rapidly respond to a secondary Plasmodium infection (Krishnamurty, Immunity, 2016). Since then, post-doc Gretchen Harms Pritchard has been working out the cues that lead to the formation of these cells. ⤵️

Journal of Experimental Medicine@jem.org · 2mo ago

Harms Pritchard, @marionpepper.bsky.social et al. dissect key CD4⁺ T cell/B cell interactions to define signals that govern the development of memory B cell populations. rupress.org/jem/article/... #InfectiousDisease #HostDefense #LymphocyteBiology #BCells