Tessera

James Conway

@jrwconway.bsky.social

Cancer researcher working in Finland Lab website(s): https://research.tuni.fi/tme/ https://www.helsinki.fi/en/researchgroups/tumour-microenvironment-and-metastasis

5 Posts144 Follower 69 Folgt

Journal of Cell Science @jcellsci.bsky.social · last mo.

In this Review, James Conway @jrwconway.bsky.social discusses how integrin function is dynamically shaped by post-translational modifications. journals.biologists.com/jcs/article/...

Schematic of several PTMs investigated for their roles in regulating integrin functions. PTMs occurring on integrin β-subunits, including some of their known regulators and adaptors are shown. Integrins span the plasma membrane, with large extracellular domains that bind extracellular matrix (ECM) ligands, and short cytoplasmic tails that serve as platforms for intracellular signalling and mediate binding to the cell cytoskeleton. Glycosylation adds sugars to the extracellular domains via glycosyltransferases and glycosidases. Phosphorylation of conserved tyrosine (Y) or serine (S) and threonine (T) residues in the cytoplasmic tails can regulate the binding of different adaptor proteins and supports the dynamic roles of integrins during cell migration. Some of the known kinases and phosphatases that add or remove these modifications, respectively, are shown. Further PTMs can be made to other cytoplasmic residues, including ubiquitylation (i) or acetylation (ii) of lysine residues (K).

James Conway @jrwconway.bsky.social · 2mo ago

In the process of moving the lab to Tampere University, but our new website is already live research.tuni.fi/tme/

Tumour Microenvironment and Metastasis | Tampere Universities

research.tuni.fi

James Conway @jrwconway.bsky.social · 3mo ago

New paper from the lab where we successfully image CFP/YFP-based FRET reporters in parallel with a second FRET reporter composed of mRuby2/miRFP670nano3 in the same cell onlinelibrary.wiley.com/doi/10.1002/...

Red‐to‐Near‐Infrared Fluorescence Resonance Energy Transfer Reporters for Dual Imaging Applications

Genetically encoded FRET biosensors reveal dynamic signaling in living cells, but overlapping spectra have limited the simultaneous monitoring of multiple pathways. We introduce a red-to-near infrare...

onlinelibrary.wiley.com

James Conway @jrwconway.bsky.social · last yr.

New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...

James Conway @jrwconway.bsky.social · 2y ago

Ready to share our work as a poster at the upcoming Lorne Cancer Conference! Looking forward to discussing the role of integrin β1 in cancer invasion, and connecting with experts in the field. #LorneCancer2025