Tessera

Journal of Cell Science

@jcellsci.bsky.social

Journal of Cell Science (JCS) publishes cutting-edge science encompassing all aspects of cell biology. JCS is a community journal published by The Company of Biologists (@biologists.bsky.social), a not-for-profit organisation. #cellbiology #cellbio

994 Posts5956 Follower 1664 Folgt

Journal of Cell Science @jcellsci.bsky.social · 6h ago

We invite you to submit your latest research to our upcoming special issue: Proteostasis. This issue will be coordinated by two of our Academic Editors: Pedro Carvalho and Tamotsu Yoshimori. journals.biologists.com/jcs/pages/pr...

Journal of Cell Science @jcellsci.bsky.social · 7h ago

Samuel Stack-Couture, Patrick Lajoie and colleagues discover that Hac1-independent functions of Ire1 drive morphogenesis in Candida albicans through distinct transcriptional programs. journals.biologists.com/jcs/article/... #OpenAccess #ReadandPublish

Figure showing that the top 20 genes upregulated in an Ire1- and serum+37°C-dependent manner, comprising cluster 6, are under control of morphogenesis transcription factors.

Journal of Cell Science @jcellsci.bsky.social · yesterday

Yitao Shen, Melissa Rolls and colleagues find that Patronin promotes the formation of dynamic microtubule seeds in vivo. journals.biologists.com/jcs/article/...

Pastor-Pareja Lab @pastorparejalab.bsky.social · 2d ago

Our new study on how endoplasmic reticulum exit sites are formed is out in @jcellsci.bsky.social: "Cooperative definition of ER exit sites by Tango1, Sec16 and Sec12" journals.biologists.com/jcs/article/...

Journal of Cell Science @jcellsci.bsky.social · 2d ago

Issue 14 is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows annulate lamellae at ER–mitochondria contact sites, marked by Nup358 (green) and mitochondria (magenta). See article by Oliveira & Joseph. journals.biologists.com/jcs/article/...

$JCS cover: Annulate lamellae (AL) at endoplasmic reticulum (ER)–mitochondria contact sites (ERMCSs). Super-resolution image of HeLa cells showing Nup358-positive structures (green) and mitochondria (magenta). In addition to its localization at nuclear pore complexes (prominently concentrated around the nucleus at the centre of the cell), Nup358 is present in cytoplasmic AL, specialised ER subdomains enriched with a subset of nucleoporins. A fraction of these AL structures is closely associated with mitochondria, indicating their localization at ER–mitochondria contact sites (ERMCSs). Images were acquired using a Nikon Eclipse Ti2 microscope equipped with the CREST Optics DeepSIM X-Light super-resolution imaging module. Picture credit: Gowhith Kuppili. See article by L. Oliveira and J. Joseph. (jcs264633).$

Journal of Cell Science @jcellsci.bsky.social · 5d ago

Niharika Patel, Daniel Conway and colleagues find that apical-out polarity in epithelial spheroids requires α6β4 integrins, cell proliferation and anchorage independence. #OpenAccess #ReadandPublish journals.biologists.com/jcs/article/...

Proposed mechanism for eversion. Epithelial cells in Matrigel or collagen develop with apical-in polarity, forming a single hollow lumen. Local breaks in cell–cell adhesions can induce a rapid collapse of the lumen. This is then followed by a collective migration, using α6β4 interactions across the laminin network that everts the spheroid.

Journal of Cell Science @jcellsci.bsky.social · 5d ago

Richa Maheshwari, Orna Cohen-Fix @ornacf.bsky.social and colleagues find that the C. elegans centriculum, a centrosome-associated membrane reticulum, may act as a filter, limiting microtubule growth. #OpenAccess journals.biologists.com/jcs/article/...

Figure showing the spatial relationship between the centrosome, centriculum and peri-centrosomal microtubules.

Journal of Cell Science @jcellsci.bsky.social · 6d ago

Bappi Sarkar, Mousumi Mutsuddi & Ashim Mukherjee discover that Mask modulates Toll signalling by regulating the levels of Cactus in Drosophila. journals.biologists.com/jcs/article/... Read more about this research in our interview with Bappi Sarkar: journals.biologists.com/jcs/article/...

Figure showing that the full-length Mask protein is essential for Toll signalling activation.

Journal of Cell Science @jcellsci.bsky.social · 6d ago

Yukiko Nakase, Shet Lee Ng and colleagues find that multimodal coordination of ammonium transporters helps fission yeast survive. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

Figure showing that the proteins Amt1, Amt2 and Amt3 exhibit varying expression levels.

Journal of Cell Science @jcellsci.bsky.social · last wk.

Igor Yakunin, Sean Munro @cellbiol-mrclmb.bsky.social and colleagues find that the Golgi vesicle tether p115 can bind directly to the ER exit site organiser Sec16A. #OpenAccess #ReadandPublish journals.biologists.com/jcs/article/...

AlphaBridge visualisation of the output from an AlphaFold 3 prediction of a complex between the N-terminal region of Sec16A (1–1100) and the head domain of p115 (1–630). Shown in orange and blue are the two high-confidence interactions identified by AlphaBridge, both of which have a predicted interaction confidence score (piCS) of 0.91 (Álvarez-Salmoral et al., 2025 preprint). The predicted local distance difference test (pLDDT) score of ≤50 indicates that most of the indicated region of Sec16A is predicted to be unstructured. (C) AlphaFold 3 prediction of the complex formed between residues 701–755 of Sec16A and the head domain of p115. The residues of Sec16A lie along a groove in the surface of p115, with two regions predicted to interact with very high confidence. Shown in red are short stretches of residues in the middle of each region that were selected for mutation to alanine.

Quentin Frenger @frengerquentin.bsky.social · last wk.

Happy to share that our study is now published @jcellsci.bsky.social ! doi.org/10.1242/jcs....

Vimentin intermediate filaments support autophagosome biogenesis at ER–endosome contact sites in response to starvation

Highlighted Article: Vimentin intermediate filaments rapidly reorganize to mobilize ER–endosome contact sites, establishing a crucial spatial platform for starvation-induced autophagy initiation.

doi.org

Quentin Frenger@frengerquentin.bsky.social · 8mo ago

My first postdoc preprint is out! Upon starvation, the Vimentin IFs network rapidly compacts (in <15 min!) to "cage" ER-Endosome membrane contact sites. This spatial confinement is crucial for autophagosome biogenesis. www.biorxiv.org/content/10.6... #CellBiology #Autophagy #Vimentin

Journal of Cell Science @jcellsci.bsky.social · last wk.

In their Opinion article, Hemmo Meyer @hemmo-lab.bsky.social @unidue-zmb.bsky.social, Akiko Kuma and Shuhei Nakamura discuss the concept of lysosome regeneration and provide guidance for interpreting markers and assays used to study lysosomal damage responses. journals.biologists.com/jcs/article/...

Schematic showing the diverse pathways in the lysosomal damage response.

Journal of Cell Science @jcellsci.bsky.social · last wk.

Carolyn Ott @hhmijanelia.bsky.social, Jennifer Lippincott-Schwartz & David Breslow @davidbreslowlab.bsky.social explain how recent advances have expanded our models of primary cilia disassemble and discuss emerging roles of altered disassembly in disease. journals.biologists.com/jcs/article/...

Schematic showing the mechanisms contributing to cilia disassembly.

Journal of Cell Science @jcellsci.bsky.social · last wk.

Hannah Hertz, Ian Price and Wen Tang find that the kinetochore component HCP-1 forms cytoplasmic granules in the Caenorhabditis elegans germline. journals.biologists.com/jcs/article/... #OpenAccess #ReadandPublish

Figure showing that perinuclear HCP-1 translocates into nuclei during mitosis.

Journal of Cell Science @jcellsci.bsky.social · last wk.

We're pleased to be supporting the FASEB Lipid Droplets/Phospholipids conference taking place this week. If you're attending the meeting and would like to discuss a submission, please get in touch. @faseborg.bsky.social #LipidSRC #PLSRC

Journal of Cell Science @jcellsci.bsky.social · last wk.

Anna-Lena Klemke, Xiaodi Hu, Reinhard Fischer and colleagues discover that the fungal virulence factor PefD activates sleep neurons of C. elegans. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

Journal of Cell Science @jcellsci.bsky.social · last wk.

Douglas Weidemann, Silke Hauf @silkehauflab.bsky.social and colleagues @virginiatech.bsky.social establish MS2–MCP-based single-molecule RNA visualisation in Schizosaccharomyces pombe. journals.biologists.com/jcs/article/...

Kate Miroshnikova @katemiro.bsky.social · 2w ago

🤩🤩🤩It was a pleasure & a lot of fun, as always, to work with @jcellsci.bsky.social on this - congratulations on a fantastic issue all about the #nucleus 😎😎😎

Journal of Cell Science@jcellsci.bsky.social · 2w ago

We spoke to Kate @katemiro.bsky.social about her ‘random walk’ into cellular biophysics, how AI might uncover links between nuclear morphodynamics and cell fate hiding in plain sight, and fishing for crayfish as a child growing up in Kazakhstan. journals.biologists.com/jcs/article/...

Kate and her ‘girls’ – mom and granny, wine tasting from test tubes somewhere around Washington, D.C. Through their constant love, kindness and support, these two trailblazer women in their own rights have always been my strength and super-power.

Journal of Cell Science @jcellsci.bsky.social · 2w ago

In their Tools and Resources article, Ranran Mao, Jia-Jia Liu @rainier2009.bsky.social and colleagues present their new split GFP-based biosensors for detecting ER-Golgi membrane contact dynamics. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

Characterization of the EGCS biosensors by super-resolution microscopy.

Journal of Cell Science @jcellsci.bsky.social · 2w ago

New JCS snapshot - A ULK1–MTFR1L feedback loop links mitochondrial fission, mitophagy and apoptosis @riccardobabic.bsky.social, Leon Lucya & Christoph Reiter present the key findings from their JCS paper with Claudine Kraft & team @kraftlabfr.bsky.social. journals.biologists.com/jcs/article/...

Journal of Cell Science @jcellsci.bsky.social · 2w ago

Our Cell Scientist to Watch interviews in our Cell Biology of the Nucleus Special Issue are with Kate Miroshnikova @katemiro.bsky.social and Andrew Stephens @andrewdstephens.bsky.social. journals.biologists.com/jcs/issue/13...

Journal of Cell Science @jcellsci.bsky.social · 2w ago

In their Perspective article, Marintia Nava-García @marintianava.bsky.social, Michelle Baird @michelleabaird.bsky.social and colleagues discuss the emerging roles of lipids in nuclear function and homeostasis. journals.biologists.com/jcs/article/...

Schematic overview of the lipid metabolic pathways and membrane remodeling processes occurring at the NE and within the nucleus.

Journal of Cell Science @jcellsci.bsky.social · 2w ago

In their Cell Science at a Glance article & poster, Pascal Höhne, Marie Hugenroth & Maria Bohnert @bohnertlab.bsky.social @uni-muenster.de highlight the multifunctionality & metabolic plasticity of the NVJ & its integration into the contact site network. journals.biologists.com/jcs/article/...

JCS poster: The nucleus–vacuole junction at a glance

Journal of Cell Science @jcellsci.bsky.social · 2w ago

Did you know that JCS publishes Short Reports? These articles (of up to 3000 words and 4 display items) report a significant finding that furthers our understanding of cell biology and provides the foundation for future studies. Find out more: journals.biologists.com/jcs/pages/re... #notforprofit

Journal of Cell Science @jcellsci.bsky.social · 2w ago

In this Review, Coral Zhou dissects the causes and consequences of genome size variation from the perspective of 3D genome organisation. journals.biologists.com/jcs/article/...

Cartoon speculating how changes in genome size are reflected at the level of single nucleosomes, TADs and subnuclear compartmentalisation. How do genomes adapt to changes in size? As genomes get bigger, their organization in 3D space dramatically shifts in ways we do not understand, likely requiring innovations at the molecular scale in order to maintain the same functions. Here we speculate on these changes at the level of single nucleosomes, TADs and subnuclear compartmentalization. (A) Based on previous work in Drosophila suggesting that heterochromatin machinery is titrated with increasing genome content (Dimitri and Pisano, 1989), we speculate that H3K9me3, an epigenetic mark associated with heterochromatin, will be less abundant on newly polyploid genomes. (B) Based on some evidence from axolotl (Schloissnig et al., 2021), we also hypothesize that TADs will generally scale with increasing genome size. (C) As genomes get bigger, nuclei also grow, resulting in a decrease in the ratio between nuclear surface and nuclear volume. Since the nuclear envelope is the source of many nuclear activities, including nuclear transport and communication with the endoplasmic reticulum, we speculate that major changes in nuclear shape and an increase in NPCs are required to accommodate a bigger genome. We also hypothesize that membraneless subnuclear compartments such as the nucleolus and heterochromatin domains will scale with genome size, and it will be interesting to measure how these changes affect ribosomal RNA production and gene silencing, respectively. Created in BioRender by Zhou, C., 2026. https://BioRender.com/6dz6avq. This figure was sublicensed under CC-BY 4.0 terms.

Journal of Cell Science @jcellsci.bsky.social · 2w ago

In this Opinion article, Peter Cook looks at the impact of clusters of RNA polymerases in linking DNA sequence and cell fate. journals.biologists.com/jcs/article/...

Waddington landscapes and transcriptional noise. Iconography adapted from Waddington (1957) and Urban and Johnston (2018). (A) Example landscape. Top, a stem cell (blue ball) differentiates as it rolls down through the landscape towards different valleys leading to different cell fates, presented here as fibroblast, myoblast or neuron. Bottom, according to the traditional model, individual lineage-specific genes are transcribed in different local minima. (B) Transcriptional noise is visualized as a transient ‘speed bump’ that diverts a fibroblast progenitor incorrectly down the myoblast path. (C) Increasing valley depth mitigates the effect of a speed bump. (D) Clusters will be in deeper minima, mitigating effects of transcriptional noise.

Journal of Cell Science @jcellsci.bsky.social · 2w ago

Haritha Prabha, Priscilla Phan and Daniel Levy review the emerging mechanisms regulating nuclear scaling and morphology. journals.biologists.com/jcs/article/...

Cartoon showing the regulators of nuclear size. (A)A variety of different biophysical forces are thought to act on the nucleus. Nucleocytoplasmic transport dictates the proteomes of the nucleoplasm and cytoplasm, which each give rise to different densities & osmotic pressures in these two compartments. Lower density in the nucleoplasm correlates with higher macromolecular diffusion rates. The NE is viscoelastic, which allows for NE growth while also producing membrane tension that can restrict growth. Weakening of the NE can cause membrane blebs that rupture & repair, also affecting nuclear size and shape. The overarching model is that the magnitude of these different biophysical forces and how they balance each other determine steady-state nuclear size in different cell types, developmental stages & organisms. However, in many instances, rigorous testing of this model awaits future investigation. (B) LINC complexes mediate interactions between the lamina & chromatin inside the nucleus & the actin & microtubule (MT) cytoskeletons in the cytoplasm, producing mechanical forces on the NE that affect nuclear size & shape. Additionally, force produced by intranuclear F-actin can drive nuclear growth and cytoplasmic vimentin filaments can resist NE deformation. (C) Other NE components that mechanically influence nuclear size include lamins and lamin–histone interactions, heterochromatin-binding proteins and lipid composition. (D) Chromatin is another mechanical effector that produces force on the NE. Chromatin forces are influenced interdependently by chromatin amount, histone modifications, chromatin compaction and stiffness, chromatin topology, chromatin-associated RNAs and protein condensates. H3K9ac, histone H3 acetylated at K9; H3K9me, histone H3 methylated at K9; H3K4me3, histone H3 trimethylated at K4; H3K27me3, histone H3 trimethylated at K27. Created in BioRender. Prabha, H., 2026. https://BioRender.com/5qy8f5g. This figure was sublicensed under CC-BY 4.0 terms.

Journal of Cell Science @jcellsci.bsky.social · 2w ago

In their Review, Caleb Embree @cembree.bsky.social & Katherine Borden summarise the similarities & differences of mRNA cap-binding chaperone proteins NCBP1–NCBP2 & eIF4E, describing their roles in mRNA processing in the nucleus & in translation. journals.biologists.com/jcs/article/...

Simplified summary of the journey of mRNA through cap-chaperone regulated RNA metabolism steps.

The Company of Biologists @biologists.bsky.social · 2w ago

Our CEO, Claire Moulton, is retiring this week. We will miss Claire’s leadership – her enthusiasm and innovative approach have supported the Company through many major projects – but we wish her all the best for her well-deserved retirement. www.biologists.com/stories/a-bi...

A big thank you to Claire Moulton

We are saying goodbye to Dr O. Claire Moulton this week, who is retiring from her role as CEO of The Company of Biologists. We’d like to take this opportunity to look back at Claire’s career and her i...

biologists.com

Maria Bohnert Lab @bohnertlab.bsky.social · last mo.

Our @jcellsci.bsky.social poster article “The nucleus-vacuole junction at a glance” is out! Big thanks to @abbybuch.bsky.social and @luskinglab.bsky.social for organizing an amazing special issue “Cell biology of the nucleus”. #ContactSites journals.biologists.com/jcs/article/...

The nucleus–vacuole junction at a glance

Summary: The nucleus–vacuole junction is a prominent contact site linking the nuclear ER and the yeast vacuole. We highlight the physiological implications and metabolic plasticity of this unique orga...

journals.biologists.com