Delighted to host @jborniger.bsky.social from @cshlnews.bsky.social for our @cdi-einstein.bsky.social seminar series next week. Jeremy is developing highly innovative work in the space of neurosciences and cancer. Thanks for joining us!
Aguirre-Ghiso Lab
@jaguirreghisolab.bsky.social
We study how micro-environmental and epigenetic mechanisms drive cancer cells into dormancy. We seek to control this biology to prevent and treat metastasis. https://einsteinmed.edu/faculty/16974/julio-aguirre-ghiso
Delighted to have contributed this preview with Anna Adam-Artigues, PhD & Deisy Segura Villalobos from my lab on the paper below from the Valiente lab. Outstanding work revealing a vulnerability in early stages of brain metastasis! Congrats to Manuel & the entire team! www.cell.com/cancer-cell/...
The wu wei of brain metastases: When the gift of a pause is also a vulnerability
In this issue of Cancer Cell, García-Gómez et al. show that brain-seeding cancer cells exploit an MXD4-dependent proliferative pause that enables survival under stress before metastatic outgrowth. By ...
cell.com
www.cell.com/cell-reports... @cdi-einstein.bsky.social
An extramedullary bone model of metastatic dormancy reveals an increased rate of metastatic reactivation upon distant insults
Di Blasio et al. use murine skeletal progenitors to bioengineer extramedullary bone, showing that metastatic breast cancer cells can enter dormancy, characterized by quiescence and low proliferation. ...
cell.com
Today I had a fantastic day at the @ucsandiego.bsky.social Moores Cancer Center. Thanks to my friend and colleague Silvio Gutkind for the invitation and organizing such a productive day starting with breakfast by the beach! Until next time!
www.biorxiv.org/content/10.6...
Highly plastic macrophage niches orchestrate acquired quiescence and reactivation in breast-cancer bone metastasis
Recurrence and metastasis remain major causes of cancer mortality, sustained by therapy-resistant micrometastatic cells. Bone is a frequent site of breast-cancer relapse, yet the cues that reawaken di...
biorxiv.org
Our lab is recruiting newly graduated PhDs to develop postdoctoral training in our lab @cdi-einstein.bsky.social @einsteinmededu.bsky.social. Join a vibrant environment also at our Department of Cell Biology ranked top 10 nationally for overall NIH funding & top 5 for NIH funding per investigator.
Excited to see this preprint by the Hodgson lab on the role of ARHGAP20, also found in early DCCs, as a regulator of cell migration via coordination of Rap1A & RhoA signaling through intracellular vesicular trafficking. Delighted to have helped on this work-Congrats! www.biorxiv.org/content/10.6...
ARHGAP20 organizes spatial Rap1–RhoA signaling coordination controlling adhesion dynamics during migration
Cell migration requires the precise coordination of signaling pathways that regulate cytoskeletal dynamics and adhesion turnover. Rho GTPase–activating proteins (RhoGAPs) play critical roles in shapin...
biorxiv.org
Very interesting dissection of how HER2 isoforms may contribute to early dissemination and "go" vs "grow" programs. "Go" programs may not be equal to metastasis, as these lesions "grow". These isoforms may inform on propensity to DCC dormancy. Great work! www.biorxiv.org/content/10.6...
So cool that our latest review has made the cover of @natrevcancer.nature.com with beautiful art by Lara Crow. Thanks for selecting our work. This is the third time! 😀 www.nature.com/nrc/
Nature Reviews Cancer
Nature Reviews Cancer publishes a dynamic and accessible mix of Reviews, Perspectives, Progress and Highlight articles on the most important primary research ...
nature.com
Honored to receive the Paget-Ewing award from the @metastasisresearch.bsky.social from @alanawelm.bsky.social and receive a sculpture from @bryanwelm.bsky.social - I feel so fortunate. Thanks!
Looks like mechanisms and functional analysis of early dissemination phenotypes is arriving to CRC! Which may also open up more work on how the early lesions seed organs with dormancy prone seeds of metastasis. www.nature.com/articles/s41...
Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers - Nature
Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue archit...
nature.com
🚀 As we embark on this exciting journey, I will be actively looking out for passionate researchers (students, postdocs, research technicians) excited to tackle questions at the bleeding edge of myeloid immunotherapy. *Please reach out via email if interested!*
Lastly, I’m fortunate to have my science supported by public funding, notably @sinaiimmuno.bsky.social o.bsky.social, @washumedicine.bsky.social, @theNCI during my time in the US, and @ncbsbangalore.bsky.social, @csir_IND earlier in my career in India.
I am also grateful for my wider mentorship circle, including but not limited to Josh Rubin, @brownlab1.bsky.social l, @tommarron.bsky.social sky.social, Sai Ma, Emily Bernstein, Dan Puleston who have supported me throughout my journey in tangible and intangible ways.
I want to thank my mentors who have trained me, inspired me, and championed me – @miriammerad.bsky.social, but also @DeNardoLabWUSM and @Srikalaraghavan. I hope to follow in their footsteps and pay it forward by cultivating a collaborative, inclusive, and passionate lab group.
I am so excited to be part of @jaguirreghisolab.bsky.social's bold vision for the CDI, and thrilled to be welcomed by @bowmaniacs.bsky.social, @lindsaylafave.bsky.social, @sdeoliveira.bsky.social, @steidluli.bsky.social and the larger Einstein community.
🧬 Our lab will study how blood-forming sites such as the marrow and spleen respond to cellular stress associated with cancer inflammation and therapeutic pressures, and how these interactions shape progression, metastasis, and dormancy exit. Check out website for more details !
our lab website: samhegdelab.org 🌲 Our group will be part of the MECCC Cancer Dormancy Institute @cdi-einstein.bsky.social, and academically within the Department of Developmental and Molecular Biology (DMB) at the intersection of systems immunology and hematopoietic development in inflammation.
Lab of Reactive Myeloid Cell Biology
Cancer Dormancy Institute, Montefiore Einstein Comprehensive Cancer Center (MECCC). Non-institutional website for the laboratory headed by Dr. Samarth Hegde, Department of Developmental and Molecular ...
samhegdelab.org
🌟 In a month, the Hegde Laboratory opens at @einsteinmededu.bsky.social . While this marks the culmination of more than a decade of collaborative research with exceptional mentorship, it also represents an exciting new chapter in our collective quest for the development of next-gen myeloid drugs.
Yesterday we gathered the NCI U01 Met Net grant team @einsteinmededu.bsky.social w/ @soledadsosalab.bsky.social & Brian Brown @sinaiimmuno.bsky.social. Strong talks from Carolina, Luis, Xiao, Bhavia, & our keynote speaker Simone Sidoli on aging & chromatin. Great team tackling metastasis.
www.nature.com/articles/s41...
Non-invasive profiling of the tumour microenvironment with spatial ecotypes - Nature
Multimodal machine learning reveals that tumour microenvironments can be decomposed into spatially organized multicellular ecosystems, termed spatial ecotypes, that can be accessed non-invasively via ...
nature.com
www.nature.com/articles/s41...
Evolutionary characterization of lung cancer metastasis - Nature
DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...
nature.com
Beautiful and important work from @zhanglab.bsky.social - Congrats! www.cell.com/cell/abstrac...
Unbiased niche labeling maps immune-excluded niche in bone metastasis
An unbiased niche-labeling method, SAMENT, maps cellular and molecular features of metastatic niches and highlights the role of ERα⁺ niche macrophages in preventing T cell infiltration, thereby promot...
cell.com
Exciting findings showing that DEC2 coordinates dormancy and immune-evasion in PDAC further linking it to circadian regulation. We revealed DEC2 function in cancer dormancy in two papers in 2009 and 2013. Great to see this biology expanded to PDAC. Congrats! www.cell.com/developmenta...
We are excited to share our new and third Review in Nature Reviews Cancer, “The sleeping threat: targeting cancer dormancy to transform metastasis therapy.” www.nature.com/articles/s41...
The sleeping threat: targeting cancer dormancy to transform metastasis therapy - Nature Reviews Cancer
This Review synthesizes emerging insights into how microenvironmental cues, epigenetic programmes and immune interactions govern disseminated cancer cell dormancy and outlines how advances in dormancy...
nature.com