Cancer Dormancy Institute @ Einstein
@cdi-einstein.bsky.social
Our goal is to understand how host niches, epi/genetics, aging, lifestyle and treatments influence residual cancer dormancy to detect, prevent and treat cancer relapse https://montefioreeinstein.org/cancer/research/cdi
Congratulations to one of the rising stars at the @soledadsosalab.bsky.social and @cdi-einstein.bsky.social for this impressive recognition! montefioreeinstein.org/news/2026/07...
Carolina Rodriguez Tirado, Ph.D., Receives Dr. Eddie Méndez Scholar Award
montefioreeinstein.org
www.nature.com/articles/s41...
An anti-PMEL antibody−drug conjugate with a Gq/11 inhibitor payload in GNAQ/GNA11-mutant melanomas: a phase 1 trial - Nature Medicine
In a phase 1 trial, treatment with the antibody−drug conjugate DYP688, targeting PMEL and delivering a Gq/11 inhibitor, in patients with GNAQ/GNA11-mutant metastatic uveal melanoma or other GNAQ/GNA11...
nature.com
link.springer.com/article/10.1...
Spatial ecology of breast cancer reveals co-evolution of proliferative and dormant niches - Genome Medicine
Background Cancer progression involves not only uncontrolled proliferation but also the strategic entry of tumour cells into reversible (quiescent) or irreversible (senescent) states of cell cycle arr...
link.springer.com
www.nature.com/articles/s41...
Quiescent tumor cells shape the immunosuppressive microenvironment in pancreatic cancer - Nature Communications
CAR T cell therapy remains largely ineffective in solid tumors, where quiescent cancer cells contribute to treatment resistance. Here, the authors identify a population of quiescent pancreatic cancer ...
nature.com
Interesting predictions using mathematical modeling of the ERK/p38 activity ratio and its role in cancer dormancy revealed in 2001 by Julio Aguirre-Ghiso @jaguirreghisolab.bsky.social and Liliana Ossowski. www.frontiersin.org/journals/imm...
Frontiers | A multiscale model reveals how ERK/p38-regulated dormancy shapes tumor-immune dynamics and immunoediting outcomes
IntroductionImmune responses in cancer arise from dynamic interactions across biological scales, linking intracellular signaling, cellular phenotypic plastic...
frontiersin.org
our lab website: samhegdelab.org 🌲 Our group will be part of the MECCC Cancer Dormancy Institute @cdi-einstein.bsky.social, and academically within the Department of Developmental and Molecular Biology (DMB) at the intersection of systems immunology and hematopoietic development in inflammation.
Lab of Reactive Myeloid Cell Biology
Cancer Dormancy Institute, Montefiore Einstein Comprehensive Cancer Center (MECCC). Non-institutional website for the laboratory headed by Dr. Samarth Hegde, Department of Developmental and Molecular ...
samhegdelab.org
🧪 So excited 🤗 for Hegde Lab @samhegde.bsky.social to open activity next month and join the Developmental Molecular Biology Department and @cdi-einstein.bsky.social @einsteinmededu.bsky.social If you want to know more check below 👇🏽
Samarth Hegde@samhegde.bsky.social · 2mo ago🌟 In a month, the Hegde Laboratory opens at @einsteinmededu.bsky.social . While this marks the culmination of more than a decade of collaborative research with exceptional mentorship, it also represents an exciting new chapter in our collective quest for the development of next-gen myeloid drugs.
www.nature.com/articles/s41...
Evolutionary characterization of lung cancer metastasis - Nature
DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...
nature.com
Excellent @CancerResrch project w/top scientists to develop a digital HER2 assay w/inclusion of low/ultra-low. TY for including me and hearing comments about potential impact of diversity-no data available and noted as a limitation. www.modernpathology.org/article/S089...
Agreement Across 10 Artificial Intelligence Models in Assessing Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Breast Cancer Whole-Slide Images
Historically, eligibility for receiving human epidermal growth factor receptor 2 (HER2)-targeted therapies was limited to HER2-positive tumors (immunohistochemistry 3+ or in situ hybridization amplifi...
modernpathology.org
🚨#MRS2026 early bird registration until April 30th. From sun exposure to cell signaling: Spotlight on Dr. Carmit Levy ☀️ We are thrilled to announce that Dr. Carmit Levy from Tel Aviv University #TelAvivUni will be a featured speaker at #MRS2026 in Salt Lake City!
Somatic mutations in microglia brain cells (the same mutations as seen in cancer) are enriched in and may drive the neuroinflammation of Alzheimer's disease @cellcellpress.bsky.social cell.com/cell/fulltex...
Join MSK breast medical oncologist Dr. Sarat Chandarlapaty for a session about “Resistance to anti-HER2 ADCs” TODAY at #AACR26. @theaacr.bsky.social ⏱️: Tuesday, April 21 at 1:25pm PDT Learn more here: https://bit.ly/4934sY2 #AACR26
Delighted to represent @cdi-einstein.bsky.social and once more co-chair this meeting with my colleagues and friends Cyrus Ghajar FRED HUTCHINSON CANCER RESEARCH, @Christoph Klein University of Regensburg, and @Dorothy Sipkins Duke University. See you all in Toronto next year!
Delighted to host virtually Cathrin Brisken MD PhD for our Cancer Dormancy Institute @cdi-einstein.bsky.social seminar series. Looking forward to learning about the latest findings on breast cancer dormancy!
What if you got to work with some of your best friends on a science project? I can't publish how fun this was, but I can show you the data (🧵)! Last week, we posted our second neutrophil swarming paper to bioRxiv and I wanted to post my favorite videos here~ www.biorxiv.org/content/10.6...
mRNA vaccines continue to show major promise. In a small Phase 1 trial led by Dr. Balachandran, some patients with pancreatic cancer (one of the deadliest cancers) reached 6-year survival. This is why sustained investment in science & research matters. tinyurl.com/f4n4anhk
Join gastrointestinal medical oncologist Dr. Luis Diaz for his session about “Chemical engineering of mismatch repair deficiency to induce tumor immunogenicity” TODAY at #AACR26. @theaacr.bsky.social e ⏱️: Tuesday, April 21 at 1:25pm PDT Learn more: https://bit.ly/4cueKBm
www.nature.com/articles/s43...
Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging - Nature Aging
Investigating how aging predisposes individuals to a higher metastatic risk, the authors identify that extracellular vesicles secreted by senescent hepatocytes carry miRNAs that enhance metastatic pot...
nature.com
jamanetwork.com/journals/jam...
Adjuvant Chemotherapy Outcomes in Older Adults With Nonmetastatic Triple-Negative Breast Cancer
This cohort study assessess whether adjuvant chemotherapy is associated with breast cancer mortality among women 70 years or older with nonmetastatic triple-negative breast cancer.
jamanetwork.com
Had a great Northern NYC Heme club intro @newyorkbloodcenter.bsky.social ! Great talks across the spectrum of Heme cancer biology, Clonal hematopoiesis, blood cell development from new colleagues across NY :) @sinaiimmuno.bsky.social @cdi-einstein.bsky.social @einsteincellbio.bsky.social
🔥 19 scientists. 🌍 One global stage. Celebrating 19 @niaidnews.bsky.social awardees at our B Cells & Plasma Cells / B & T Cell Collaboration meeting! The future of immunology is here 👏 #KSBCells26 #KSBTCells26 @kimljacobson.bsky.social @deeptabhattacha.bsky.social @zivshulman.bsky.social
Huge congratulations to first author Mohd Nauman and all the co-authors and collaborators who made this story possible! @cdi-einstein.bsky.social @einsteinmededu.bsky.social @monteeinsteinpath.bsky.social
Super excited to visit NYU Cancer Center tomorrow, and catch up with friends and colleagues sharing our most recent work @cdi-einstein.bsky.social. See you!
www.nature.com/articles/s41...
A hormetic transcriptional program coregulates invasion, proliferation and dormancy to define metastatic potential - Nature Communications
PRRX1 is an epithelial– mesenchymal transition-linked transcription factor. Here, the authors discover that intermediate PRRX1 levels primes cancer cell for high invasion and metastatic fitness, where...
nature.com
Good morning! this week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation www.science.org/doi/10.1126/...
bims-proteo 2026-02-15 papers
biomed.news
