📢SAVE THE DATE! 2nd Redox Biology in Health & Disease Conference 📅Date: 25 - 28 May 2027 🌏Location: Durrës, Albania Sign up for updates to find out more information on the conference: bit.ly/4eF65xf #FusionCancerResearch #FusionMetabolism #FusionHumanDisease #RedoxBio

Congrats to Jess Ubellacker! Brilliant PI in Molecular Metabilism @met-hsph.bsky.social at Harvard TH Chan School of Public Health. @hsph.harvard. edu www.aacr.org/about-the-aa...

This kind of stable, sustained support can transform a career: @hhmi-science.bsky.social's #FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits. Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA

Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI

The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...

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✍️ Registration open: bit.ly/45jaORu Sponsored by @caixaresearch.bsky.social @fendtlab.bsky.social @arkaitzcarracedo.bsky.social @bdmanning.bsky.social

Excited about the 2026 Prague Metabolism & Signaling Symposium in Prague, Czechia, bringing together leading scientists to explore cutting-edge research in metabolism, signaling, aging, cancer, immune responses & more! 🧬🔬 📅 June 24–27, 2026 More details at 👉 praguemetabolismsymposium.com

Join us for the 2026 NYAS Cancer Metabolism conference on March 24th at NYU Langone! The poster deadline is rapidly approaching. Speakers include @airdlab.bsky.social @bensahralab.bsky.social Javier Garcia-Bermudez, Marcus Goncalves, @naama-kanarek.bsky.social @bdmanning.bsky.social Erika Pearce,

Clear evidence from Josh Shin in our lab that mTORC1 signaling and autophagy reciprocally influence the length of primary cilia. Question remains how do changes in length affect cilia signaling and function in the largely quiescent cells comprising our brains and bodies. www.cell.com/iscience/ful...

Growth factor-independent mTORC1 signaling promotes primary cilia length via suppression of autophagy

Molecular physiology; Cell biology

cell.com

Just two of thousands of such stories. substack.com/home/post/p-...

I Was Just About To When My Grant Was Cut.

We ask researchers to send us their stories of what they were working on when their research grant was cut. Today, we share the stories of Tashara and Brendan.

substack.com

I still can’t believe that all NIH grants to my colleagues at Harvard and Harvard Medical School have been nullified. And that, as a nation, we’re somehow okay with this illegal, arbitrary, and petty act. Just think of the consequences: scientists, students, and patients will all suffer.

Inspired predominantly by insightful cryo-EM structures from Yanhui Xu’s lab and @drellisdon.bsky.social on the TSC protein complex, which we have been focused on the regulation of upstream of mTORC1 for 23 years and counting. Enjoy!

Much appreciated support from biotech execs and investors 🙏 www.statnews.com/2025/06/27/b...

Proposed cuts could have ‘catastrophic effect,’ 110 biomedical, health sciences industry leaders tell Congress

Proposed cuts will have “a catastrophic effect on the advancement of biomedical and biotechnology capabilities in the United States,” more than 100 leaders of biomedical/health sciences companies tell...

statnews.com

Congrats to Yann Cormerais and the entire lab for this publication on a new mouse model that disconnects the primary signal from PI3K to mTORC1, involving Akt-mediated phosphorylation of TSC2, which I discovered as a postdoc in Lew Cantley's lab 23 years ago. authors.elsevier.com/a/1lDFh5Sx5g...

Congrats to @harperlabhms.bsky.social and colleagues in @harvardcellbio.bsky.social for this tour de force dissection of endosomes

Nature@nature.com · last yr.

Nature research paper: EndoMAP.v1 charts the structural landscape of human early endosome complexes https://go.nature.com/3Z6mJ1X

Nature research paper: EndoMAP.v1 charts the structural landscape of human early endosome complexes https://go.nature.com/3Z6mJ1X

EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature

A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.

go.nature.com

From @hsph.harvard.edu Hotamışlıgil Lab, @renata-goncalves.bsky.social identifies an important mechanism that leads to liver dysfunction in obesity—defective coenzyme Q metabolism. This finding paves the way for more targeted diabetes & metabolic disease treatments. Read more: hsph.me/mitoT2D

Newly discovered mechanism of mitochondrial dysfunction in obesity may drive insulin resistance and type 2 diabetes | Harvard T.H. Chan School of Public Health

A newly discovered mechanism that leads to liver dysfunction may be a key factor in type 2 diabetes and other metabolic disorders in individuals with obesity, according to a new study led by Harvard C...

hsph.harvard.edu

For 25 years, Dr. Manning & his lab have advanced TSC research, uncovering how the mTOR pathway shapes cell growth—and unlocking insights across cancer, diabetes & more. Research that until recently was supported by taxpayers through the NIH. #TSC #science #ResearchMatters

Brendan Manning: Unraveling the cell’s inner workings

For Brendan Manning, PhD, today’s advances in basic science are the stepping stones to the next breakthrough in treating tuberous sclerosis complex (TSC). Manning has spent the last 25 years researchi...

tscalliance.org

I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding. It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job. unbreaking.org/issues/medic...

Medical Research Funding — Unbreaking

How the administration is breaking the government, and what that means for all of us.

unbreaking.org

28 of the most important drugs approved by the Food and Drug Administration (FDA) between 1985 and 2009. They found that 80 percent stemmed directly from basic discoveries made in the lab, often by scientists trying to understand a biological process or disease bit.ly/4jLCfbC

Tracing the Path from Basic Research to Transformative Therapies

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Why?

I thank the taxpayers of the United States for supporting this research designed to better understand and treat the uncontrolled growth of cancer cells over the past 10 years.

Brendan Manning@bdmanning.bsky.social · last yr.

Indeed, our Outstanding Investigator Award from the National Cancer Institute, which funded all research personnel and activities in my modest-sized lab of 5 has been unceremoniously terminated.

Indeed, our Outstanding Investigator Award from the National Cancer Institute, which funded all research personnel and activities in my modest-sized lab of 5 has been unceremoniously terminated.

Harvard T.H. Chan School of Public Health@hsph.harvard.edu · last yr.

Harvard Chan scientists participate in a rigorous application process for federal grants to conduct their vital health research. The government has now terminated nearly every single one of those grants.

With nearly all of Harvard Chan School’s direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work: hsph.me/whygive

A reminder that for next month’s BCDI in place of our regular discussion, we encourage you to attend the Cutter Distinguished Lecture @met-hsph.bsky.social by the great Scott Dixon! See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm

From Nobel prize winning cancer researcher Bill Kaelin Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...

Our partnership with the federal government has powered discoveries and solutions that have saved tens of millions of lives around the world. 🌎 The funding has enabled breakthrough research on deadly diseases from cancer to Alzheimer’s to stroke to HIV. 🦠 hsph.harvard.edu/news/trump-a...

Trump administration freezes $2.2 billion in grants to Harvard | Harvard T.H. Chan School of Public Health

The Trump administration announced late Monday that it was moving to freeze $2.2 billion in grants and $60 million in contracts to Harvard University. The federal freeze came hours after Harvard rejec...

hsph.harvard.edu

Check out the new homepage for Harvard!! Love it !! www.harvard.edu

Harvard University

Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders who make a difference globally.

harvard.edu

With support from federal funding, @hsph.harvard.edu faculty have conducted groundbreaking research that has led directly to treatments, policies, and programs that have saved lives by the millions, in the US and around the world. Here are just three examples: hsph.harvard.edu/news/federal...

Federal funding drives groundbreaking research at Harvard Chan School | Harvard T.H. Chan School of Public Health

Harvard Chan faculty conduct groundbreaking research that has led directly to lifesaving vaccines, treatments, policies, and programs.

hsph.harvard.edu

Tough day on the slopes trying to keep up with these guys. But beats watching the news.

There it is! The end of academic science in the US. grants.nih.gov/grants/guide...

Last day to apply to the hub of metabolism research at Harvard.

Brendan Manning@bdmanning.bsky.social · 2y ago

Join us in Boston! The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health has just opened a Jr. Faculty search. Apply by January 15, 2025 at academicpositions.harvard.edu/postings/14371