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Sho Takeshita 竹下翔

@takeshita-sho.bsky.social

PhD candidate in Biophysics @JHU. Interested in proteins and deep learning.

6 Posts29 Follower 198 Folgt

Sho Takeshita 竹下翔 @takeshita-sho.bsky.social · 3mo ago

Competed for Hopkins at the US Croquet Association Collegiate Championship this weekend. Had a lot of fun and ended up placing top 10 with my teammate Clark which placed Hopkins 4th in the nation. BTW also passed my GBO and I am officially a PhD candidate now!

Sho Takeshita 竹下翔 @takeshita-sho.bsky.social · 5mo ago

I was testing DeepSeek's knowledge and it was interesting to see that it can hallucinate Chinese characters. However, it seems that using this Chinese character (完整=complete / intact) translated into English would provide a reasonable statement.

bioRxiv Biophysics @biorxiv-biophys.bsky.social · 5mo ago

Clathrin is an Intrinsic Driver of Membrane Fission https://www.biorxiv.org/content/10.64898/2026.03.05.709932v1

bioRxiv Biophysics @biorxiv-biophys.bsky.social · 6mo ago

Transforming macromolecular structures into simulations of self-assembly https://www.biorxiv.org/content/10.64898/2026.01.27.702082v1

bioRxiv Biophysics @biorxiv-biophys.bsky.social · 9mo ago

A membrane-driven biochemical oscillator tunable by the volume to surface area ratio https://www.biorxiv.org/content/10.1101/2025.11.14.688573v1

Sam Foley @samuelfoley.com · 10mo ago

This is a rather unfortunate change that seems to have come as a surprise to just about everyone. FYI for students and PIs who were looking to apply for the NSF GRFP

Dan Garisto@dangaristo.bsky.social · 10mo ago

As others have pointed out, the fellowship is now available only to 1st year grad students. (Left is last year, right is this year)

Be a U.S. citizen, national, or permanent resident
Intend to enroll or be enrolled full-time in a research-based Master's or doctoral degree program in an eligible Field of Study in STEM or STEM education (See Appendix and Section IV.3 for eligible Fields of Study
Never previously accepted a Graduate Research Fellowship
Declined any previously offered Graduate Research Fellowship by the acceptance deadline
Never previously applied to GRFP while enrolled in a graduate degree program
Never earned a doctoral or terminal degree in any field
Have completed no more than one academic year (according to institution's academic calendar) while enrolled in a graduate degree program (non-degree coursework must be clearly identified in the transcript and does not count toward this limit)
Individuals holding joint Bachelor's-Master's degrees who did not apply while enrolled in the joint program, may apply as second-year graduate applicants if enrolled in an eligible doctoral program the beginning of the academic year immediately following the academic award year of the joint degree
Individuals with prior graduate enrollment who have: (i) completed more than one academic year in any graduate degree-granting program, (ii) earned a previous master's degree of any kind (see guidance for joint Bachelor's-Master's degree-holders above), or (iii) earned a professional degree must meet the following requirements:
not enrolled in a graduate degree program at application deadline
two or more consecutive years past graduate degree enrollment or completion at the application deadline
Not be a current NSF employee.

Erica D. Pratt @pratted.bsky.social · 10mo ago

Announcing such a major change to NSF GRFP this late in the cycle is incredibly cruel. 2nd yr students (mine included) have been working so hard on their proposals despite ongoing uncertainty. They are driven and passionate about being outstanding scientists and helping those coming up behind them.

This means individuals in the following statuses at the time of application are eligible:

Undergraduate in the final (senior) year of a bachelor’s degree program
Bachelor’s degree-holder with NO enrollment in a graduate degree program (non-degree graduate coursework allowed)
Individual enrolled in a joint bachelor’s-master’s degree program with at least three undergraduate years completed
First-year graduate student in their first graduate degree program with less than one academic year completed in the degree program (according to institution’s academic calendar)
Individuals enrolled in joint bachelor’s-master’s degree programs are considered graduate students. For GRFP, joint bachelor’s-master’s degrees are defined as degrees concurrently pursued and awarded.
Not be a current NSF employee.

Applications that do not meet eligibility requirements will be returned without review as being ineligible for a fellowship.

Sho Takeshita 竹下翔 @takeshita-sho.bsky.social · 11mo ago

Check out this cool manuscript I was a part of!

Samuel William Canner@swcanner.bsky.social · 11mo ago

My latest manuscript is now on BioRxiv: Evaluation of De Novo Deep Learning Models on the Protein-Sugar Interactome. where we benchmark AF3 at protein-carbohydrate docking. This work was only possible with Dr. Lei Lu @takeshita-sho.bsky.social and @jeffreyjgray.bsky.social doi.org/10.1101/2025...

bioRxiv Biophysics @biorxiv-biophys.bsky.social · 11mo ago

Evaluation of De Novo Deep Learning Models on the Protein-Sugar Interactome https://www.biorxiv.org/content/10.1101/2025.09.02.673778v1

Margaret Johnson @mejohnson81.bsky.social · last yr.

Does protein dimerization always help targeting and dwell time on DNA? Not for a population! Dwell time is especially sensitive to spacing between DNA targets. Nonspecific binding and facilitated (1D) diffusion also play a key role. Super proud of Mankun Sang’s work! doi.org/10.1101/2025...

Proteins can form dimers and bind DNA specifically and nonspecifically, exploiting 3D and 1D diffusion. This can drives both enhanced and impaired dwell time and target occupancy depending on spacing between specific targets.