Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes

The ribotoxic stress response is activated upon sensing of impaired translation by the MAP3 kinase ZAKα. Vind et al. demonstrate how ZAKα surveils the translation process and interacts with elongating, stalled, and collided ribosomes. ZAKα activation depends on ribosome-templated sequestration of inhibitory domains, dimerization, and activation-loop autophosphorylation in trans.

dlvr.it

ZAKα is a sensor of mRNA stasis at the ribosomal exit channel

Despite a growing interest in the ribotoxic stress response (RSR), it remains unknown how the upstream p38 and JNK-activating MAP3 kinase ZAKα senses translational impairment. Combining Alphafold3 pre...

biorxiv.org

Postdoc in gene expression

employment.ku.dk

The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

The acute skin reaction to sunburn, encompassing keratinocyte cell death, inflammation, and epidermal thickening, has traditionally been ascribed to DNA damage responses. Using a mouse model deficient...

cell.com