Center for Gene Expression (CGEN)
@cgen2025.bsky.social
DNRF Center of Excellence performing ground-breaking research on the multiple aspects of gene expression, based at ICMM, UCPH. Director: Jesper Svejstrup. Research groups: Simon Bekker-Jensen, Lea Gregersen, Fena Ochs, Niels Erik Møllegård and Peter Haahr.
🧬CGEN is hiring postdocs!🧬 We are looking for talented postdoctoral researchers to join our center: www.nature.com/naturecareer...
Postdocs at Center for Gene Expression in Department of Cellular and Molecular Medicine - Copenhagen, Hovedstaden (DK) job with University of Copenhagen | 12849488
We are looking for 2 or more highly motivated postdocs interested in ribosome biology, 3D chromatin organisation, or regulation of protein turnove...
nature.com
We’re excited to share that our postdocs, Catarina Pechincha and Sofia Ramalho from the Bekker-Jensen group, have been awarded prestigious EMBO Postdoctoral Fellowships! Big congrats to both! 👏
I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...
A role for human senataxin in contending with pausing and backtracking during transcript elongation
Senataxin (SETX) regulates RNA polymerase II (RNAPII) transcription and helps maintain genome stability, at least partly by suppressing R-loops. Howev…
sciencedirect.com
Exciting Expansion at CGEN! We’re thrilled to welcome Fena Ochs and Niels Erik Møllegaard. 🔬 Fena brings cutting-edge expertise in 3D chromatin organization and its role in gene regulation, DNA repair, and cell division. 🧬Niels Erik’s expertise is in genome structure and DNA helix conformation
Interested in measuring RNAPII elongation rates? We developed DRB/TTchem-seq2 to directly measure rates across 3,000+ genes 🧬 genome.cshlp.org/content/earl... This fantastic work led by Haiyue Liu reveals gene and intra-genic variation, links to histone marks & elongation factors Details below! 👇
Kinetic measurement of gene-specific RNA polymerase II transcription elongation rates
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
genome.cshlp.org
New review in Genes and Development: genesdev.cshlp.org/content/earl... Blear & Svejstrup review a critical transcription QC checkpoint at the beginning of protein-coding genes, where the cell assesses RNA polymerase II quality and decides whether it will continue, or not. @jsvejstrup.bsky.social
genesdev.cshlp.org
🌟 Check out the latest preprint from our center 🌟 This work brings us one step closer to gaining a deeper understanding of gene expression regulation - a core mission of our center 🧬 🧫 If you want to know more about CGEN visit our website: cgen.ku.dk @dg.dk @ucph.bsky.social
Center for Gene Expression – University of Copenhagen
cgen.ku.dk
Jesper Svejstrup@jsvejstrup.bsky.social · 11mo agoExtremely proud to share the impressive work done by Anouk Olthof et al. on how cells maintain healthy levels of RNAPII, and how they respond when levels are too low. Fascinating stuff, we think www.biorxiv.org/content/10.1...
Extremely proud to share the impressive work done by Anouk Olthof et al. on how cells maintain healthy levels of RNAPII, and how they respond when levels are too low. Fascinating stuff, we think www.biorxiv.org/content/10.1...
Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation
Transcription is regulated by sequence-specific transcription factors and enzymes allowing access to genes in chromatin. However, recent data indicate that the abundance of RNA polymerase II (RNAPII) ...
biorxiv.org
Four of our six Master's students successfully defended their theses last week. In the coming weeks, the remaining two will defend theirs, and Mads, our laboratory technician trainee, will also complete his training. Last Friday, we held a joint celebration at the center. Congratulations to all! ⭐
Excited to share the latest paper from CGEN just published in Molecular Cell! This study demonstrates the specificity of RNAPII-CTD kinases CDK9 and CDK12, and also describes the activation mechanism of CDK12/13 in cells by the PAF1C subunit CDC73. authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
Another opportunity to join CGEN: we are seeking 2 or more Postdocs 🧬🧪 Deadline March 18, 2025 Please share with your relevant networks! employment.ku.dk/faculty/?sho...
Postdoc in gene expression
employment.ku.dk
💥 CGEN is hiring 💥 We are looking for 2 or more highly motivated PhD students to join our DNRF Center of Excellence, Center for Gene Expression (CGEN) at University of Copenhagen. Deadline: March 6, 2025 Please share with your relevant networks! employment.ku.dk/phd/?show=16...
PhD fellowships at the Center for Gene Expression
employment.ku.dk