Mind the GAP 🚧🕳️🚧 Excited to share the latest preprint from the Fromme Lab (@fromme-lab.bsky.social), showing that the DENN domain protein Avl9 functions as an Arf-GAP, revising long-standing assumptions about DENN protein function, 🧵: www.biorxiv.org/content/10.6...

Avl9 defines a family of GTPase-activating proteins that regulate diverse cell biological functions

Ras-related GTPases are molecular switches regulating hundreds of signaling and trafficking pathways in cells. Many GTPase regulators remain to be identified despite extensive genetic and biochemical ...

biorxiv.org

Excited to share the published version of our work by @ryanfeathers.bsky.social and @rvig.bsky.social on the structural basis for activation of Rab6 by the Ric1-Rgp1 complex! rdcu.be/d2mu3 Here is an updated thread about the paper we first shared on that older platform when we posted the preprint