Fromme Lab
@fromme-lab.bsky.social
We study how cells sort important stuff around their insides and to their outsides - Cornell University in beautiful Ithaca, NY https://fromme.wicmb.cornell.edu
New study from our lab at NICHD, NIH! We identify TBC1D9 and TBC1D9B as novel ARL8 effectors that suppress exosome secretion by inactivating RAB11A and thus blocking exocyst-dependent fusion of multivesicular endosomes with the plasma membrane. www.pnas.org/doi/10.1073/...
Three PhD positions available to work on yeast lysosome biogenesis and reconstitution of membrane fusion as of July or September 2026. Details can be found here: myshare.uni-osnabrueck.de/f/76c16d1fcc...
260508_PhD positions available.pdf
Share link for 260508_PhD positions available.pdf.
myshare.uni-osnabrueck.de
The small GTPase Arf1 regulates TORC1 in two different ways! Great work by Ludovic Enkler and a great collaboration with @mihaelazavolan.bsky.social . Check out our preprint! www.biorxiv.org/content/10.6...
biorxiv.org
Here are the other articles part of the same issue :) www.sciencedirect.com/journal/curr...
Current Opinion in Cell Biology | Vol 100, In progress (June 2026) | ScienceDirect.com by Elsevier
Read the latest articles of Current Opinion in Cell Biology at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
sciencedirect.com
It was fun writing this with David @dgershlick.bsky.social! Check it our if you want to hear our view on small #GTPases networks in endosomal trafficking :) part of the themed issue on Membrane trafficking edited by @fromme-lab.bsky.social and Philippe Chavrier www.sciencedirect.com/science/arti...
Dynamic GTPase networks reshaping endosomal organelle identities
Endosomal GTPases, while often used as markers for specific endosomal organelles, functionalize the surface of endosomal compartments into biochemical…
sciencedirect.com
1 week left to submit an abstract to be considered for a talk at the FASEB GTPase conference: events.faseb.org/event/Small-...
On April 19, 1898, Camillo Golgi first described what we now call the Golgi apparatus - a structure so striking and unusual that it took more than 50 years for scientists to accept it wasn’t just an artefact. April 19 is #GolgiDay! Celebrate the cell’s most iconic and best organelle.
Another fantastic #GolgiTime paper from the Glick lab!
Journal of Cell Biology@jcb.org · 4mo agoKrahn, Glick et al. use budding yeast to examine membrane recycling at the Golgi apparatus. They describe an in vivo vesicle capture assay that reveals which resident Golgi proteins recycle together in the same vesicles. rupress.org/jcb/article/... #Organelles #Trafficking
Very proud of this tour de force from two former students, Stephanie Tanis and Leah Simon, with help from a huge team, including @charlesdanko.bsky.social highlighting a novel-overlooked intervention point for male contraception www.pnas.org/doi/10.1073/...
Meiotic prophase I disruption as a strategy for nonhormonal male contraception using small-molecule inhibitor JQ1 | PNAS
Developing safe, reversible, and nonhormonal male contraceptives has been hindered by the lack of defined biological windows that can be transientl...
pnas.org
Very exciting that our new paper on the forces exerted by the Rad51-Rad54 homology search complex is now online. This was a collaborative effort with the Wang here at Cornell, and this work performed primarily by a graduate student, Mitch Woodhouse genesdev.cshlp.org/content/earl...
The eukaryotic homology search complex distorts donor DNA structure to probe for homology
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
We offer a PostDoc position for a fully funded project on lipid-encoded #lipidtime protein quality-control checkpoints at the Golgi: great collaborators, excellent working & living conditions & benchspace with a view ;) Please share and repost!
The 2026 Otto Warburg Medal winner Maya Schuldiner received the medal from @volkerhaucke-lab.bsky.social after a moving laudatio by Christian Ungermann Thanks to @elsevierconnect.bsky.social for the continuous support!
And here is the working URL! events.faseb.org/event/Small-...
Home - Regulation and Function of Small GTPases.
Discover the latest in small GTPases research from cell signaling to disease at this global forum for biology, medicine, and therapeutic innovation.
events.faseb.org
Fromme Lab@fromme-lab.bsky.social · 4mo agoA reminder for all GTPase enthusiasts! The 2026 Regulation and Function of Small GTPases FASEB conference will be held June 21-24 in Florida, USA. The deadline to be considered for a short talk is April 27. events.faseb.org/event/Small-...
A reminder for all GTPase enthusiasts! The 2026 Regulation and Function of Small GTPases FASEB conference will be held June 21-24 in Florida, USA. The deadline to be considered for a short talk is April 27. events.faseb.org/event/Small-...
I've been leading a big project at Methods in Enzymology over the past year or so: editing three back-to-back-to-back volumes of articles describing the latest advances in methods for studying lipids and membranes — thank you to the 50 #lipidtime luminaries who contributed the 51 chapters! Details 👇
Congratulations!
Jeremy Baskin@jeremybaskin.bsky.social · 6mo agoNew paper in @jcb.org! We found a new regulator of p62 phase separation, autophagy, and antioxidant signaling. It is an E3 ligase adaptor called SHKBP1, but the effect is via direct p62 binding, not ubiquitination. Congrats to Lin Luan & team! @weillinstitute.bsky.social
Do you want to know more about how Retromer regulates Rab7 activity in yeast? Of course you do. Check out the new collaboration with Andreas Mayer with work led by Catarina Alves and Kevin Chen.
The GTPase activating protein Gyp6 binds Retromer and inactivates Rab7/Ypt7 to coordinate the formation of endosomal carriers
The Retromer coat is conserved in all eukaryotes and is crucial for the correct intracellular sorting of many transmembrane receptors and lysosomal hydrolases. Retromer is an effector of the late endosomal small GTPase RAB7 and is also implicated in its inactivation required for proper endosomal maturation. Here, we explore the role of controlled GTP hydrolysis by the RAB7 ortholog Ypt7 in the formation of Retromer-coated membrane carriers in yeast. Proximity labelling and genetic ablation identify the GTPase Activating Protein (GAP) Gyp6 as a critical regulator of Ypt7 activity in the context or Retromer. Structural studies show that Retromer recruits Gyp6 through its Vps29 subunit, which recognises a specific PL motif and a secondary binding site in the C-terminal domain of Gyp6. This interaction does not occur with other yeast GAPs. Ablation of the Gyp6-Retromer interface or the catalytic activity of Gyp6 leads to the accumulation of tubular structures on endo-lysosomal compartments and to increased association of Ypt7 with Retromer and its cargo Vps10. These results support a model in which Gyp6 controls the switch from Ypt7-dependent Retromer coat assembly and cargo collection to the departure of the carrier through membrane fission and uncoating. ### Competing Interest Statement The authors have declared no competing interest. National Health and Medical Research Council, https://ror.org/011kf5r70, APP2016410 Swiss National Science Foundation, https://ror.org/00yjd3n13, 31003A_179306, 310030_204713, 10.006.083
biorxiv.org
Weill Institute is recruiting postdocs, please share! Fischer Lab: lnkd.in/eMnveqyv Hu Lab: lnkd.in/epsGK7wd
Calling all GTPase enthusiasts! The 2026 Regulation and Function of Small GTPases FASEB conference will be held June 22-24 in Florida, USA. events.faseb.org/event/Small-...
So in awe of our neighbors, another important study from the Baskin lab using such powerfully clever and elegant tools. Feeding-Fishing for the win!
Jeremy Baskin@jeremybaskin.bsky.social · 7mo agoThrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇
Awesome opportunity!
Tara Fischer@tarafisch.bsky.social · 7mo agoPerfect time to announce that we are hiring for 1 postdoc and 1 tech to start in the Spring-Summer! If you are excited about organelle quality control, innate immunity, and/or neurodegeneration, join us at Cornell in beautiful Ithaca, NY! More info coming soon fischer.wicmb.cornell.edu pls share 🙏
We are so happy that @tarafisch.bsky.social has joined us at Cornell !!!
Weill Institute for Cell & Molecular Biology@weillinstitute.bsky.social · 7mo agoWe are absolutely THRILLED to welcome our newest faculty member @tarafisch.bsky.social to the @weillinstitute.bsky.social community. We look forward to the exciting and impactful work ahead! news.cornell.edu/stories/2026...
We are absolutely THRILLED to welcome our newest faculty member @tarafisch.bsky.social to the @weillinstitute.bsky.social community. We look forward to the exciting and impactful work ahead! news.cornell.edu/stories/2026...
Weill Institute welcomes Tara Fischer as newest research member | Cornell Chronicle
Fischer investigates how cells detect and repair organelle damage, and how these processes influence inflammation and the progression of neurodegenerative disease.
news.cornell.edu
Excited to start 2026 out with a new manuscript from our lab, please check out this thread from superstar postdoc @rvig.bsky.social about how he discovered the function of a conserved secretory protein, and how this also led him to the identification of a new family of GAP proteins!
Ryan Vignogna@rvig.bsky.social · 7mo agoMind the GAP 🚧🕳️🚧 Excited to share the latest preprint from the Fromme Lab (@fromme-lab.bsky.social), showing that the DENN domain protein Avl9 functions as an Arf-GAP, revising long-standing assumptions about DENN protein function, 🧵: www.biorxiv.org/content/10.6...
Check out our new biosensor technology to study DDR kinase signaling: ProKAS. We combine: -proteomics -engineered peptide sensors -a new concept of amino acid barcodes ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data. Just published today: rdcu.be/ePNo0
Important article from @marymunson4.bsky.social @joann-trejo.bsky.social @needhibhalla.bsky.social
Scaling back DEI programmes and the loss of scientific talent - Nature Cell Biology
Programmes that support diversity, equity and inclusion (DEI) in science are under attack in the USA. Data indicate that diversity in the scientific workforce increases creativity and success in tackl...
nature.com
🎉 Huge congrats to Maya Schuldiner from the Weizmann Institute (Israel) for the 🏅 Otto Warburg Medal 2026! Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells 🧬✨ #OWM #WeizmannInstitute @elsevierconnect.bsky.social
