Been a successful year for publications for me, but this one is special. The first language & management guidelines for Timothy syndrome & CACNA1C-Related Disorder, internationally co-produced by experts and the lived experience community, is now published in EJHG (Open Access)!

I regret to inform you that we have reached the “Broadmoor is a holiday camp” stage of right-wing discourse.

Our article, led by the remarkable Xiangling Meng, on establishing CRISPR screens in neural #assembloids and #organoids is on the cover of Nature Protocols today

Thought I'd give this place a go again. I'm Kim. I'm a psychiatrist who does research on genetics and proteomics. I also do a lot of recruitment of people with psychosis for research studies. My clinical work is in a psychiatric genetics clinic in Cardiff.

Pleased to share our new paper, out open-access in Psychological Medicine. In this work we looked at the relationship between childhood trauma, autism/ autistic traits and depression over a 28 year follow-up in the ALSPAC birth cohort.

New expert-led guidance clarifies terminology for pathogenic CACNA1C variants, defining Timothy Syndrome and introducing CACNA1C-Related Disorders (CRDs). Read the preprint: www.researchsquare.com/article/rs-8... #CACNA1C #TimothySyndrome #RareDisease

“The Experience of Itch in Autistic Adults: An Online Survey” by Tackley et al (2025) finds that autistic adults report greater itch severity and itch-related impact on their daily life than non-autistic adults. FREE until 20th June www.liebertpub.com/doi/10.1089/...

doi.org/10.1089/aut.... We asked autistic and non-autisitc people if they suffered from itch. Autistic people reported more itch, at a greater severity, and with a far greater impact. #autism #sensory

The Experience of Itch in Autistic Adults: An Online Survey | Autism in Adulthood

Background: The self-reported experience of itch for autistic people has not been studied. Anecdote, theory, and emerging research suggest that itch experience is different in autistic people, with ne...

doi.org

3 elections in as many weeks. Centre left parties in two of them take on populist right and win, in 3rd they emulate populists and lose. Could there be a lesson here? And is there even a remote chance U.K. Labour might see it?

When you were asked to return the corrected page proofs within 48 hours but four months later your paper is still not available online.

a man with a mustache is sitting on a swing in a park

ALT: a man with a mustache is sitting on a swing in a park

media.tenor.com

"We established four-part assembloids from human pluripotent stem cells, integrating somatosensory, spinal, thalamic & cortical organoids [...to...] accelerate understanding of sensory circuits & facilitate therapeutic development." Elegant work by the @sergiuppasca.bsky.social lab in @nature.com. 🧪

Human assembloid model of the ascending neural sensory pathway - Nature

A human ascending somatosensory assembloid model was developed, which integrates multiple organoids to simulate the spinothalamic pathway, demonstrating functional connectivity and responsiveness to s...

nature.com

einstein sent this to curie in 1911 when she was being harassed by tabloids. it contains everything you’d want in such a letter: (1) your haters are trash (2) you’re a baller, a true queen (3) i have determined the statistical law of motion of the diatomic molecule in planck’s radiation field 🧪⚛️

🧵 1/11 📚 Our new rapid systematic review, led by @trishgreenhalgh.bsky.social in @bmj.com examines the role of physician associates (PAs) and anaesthetic associates (AAs) in the UK. This is a crucially important question in light of the Leng Review

Starmer: "You are very, very welcome here in Downing Street. As you heard from the cheers on the street outside, you have full backing across the United Kingdom. We will stand with you and Ukraine for as long as it may take." Proud to be British tonight. #SlavaUkrainii 🇺🇦🇺🇦🇺🇦

🚨 This will become a curated list of awesome tools for complex trait genetics, **add yours**! it may become a review in which case those who contribute are invited as co-authors.

GitHub - MichelNivard/awesome-complex-trait-genetics: A list of awesome tools for complex trait genetics.

A list of awesome tools for complex trait genetics. - MichelNivard/awesome-complex-trait-genetics

github.com

My first post on Bluesky :) We’re hiring! We’re looking for a postdoc research associate, to come work with us in our national population mental health consortium. If you’re into psych epi, public health & tackling mental health inequities take a look ⏬ www.timeshighereducation.com/unijobs/mini...

Research Associate/Research Fellow in Population Mental Health job with KINGS COLLEGE LONDON | 384309

About us In April 2024, IoPPN, King’s College London led the establishment of a national disseminated population mental health consortium, as part ...

timeshighereducation.com

Our 2024 CSHL conference on human brain development and stem cell models is in full swing, with over 300 participants! This year’s event features exciting new discoveries and dynamic discussions, driven largely by the energy & insights of trainees #Assembloids #Organoids #Brain #CSHL2024Brain

A lot of people will tell you we're a Roman Palace. We are in fact a moon-sized super-weapon capable of destroying a planet. (Better with sound).

"Why should our entire built environment be optimized to amuse a sliver of one percent of the population, even granting that it amuses them very effectively?" www.astralcodexten.com/p/book-revie...

Book Review: From Bauhaus To Our House

...

astralcodexten.com

Looking forward to the biggest shakeup of the NHS since the last one…

RCPsych needs to move from Twitter to Bluesky! It’s a mental health imperative. Peers are already here.

“thanks so much for the feedback”

Disappointing to see a reviewer use a book review to so push his own ideological view of mental illness and mental health services. www.theguardian.com/books/2024/n...

An Improbable Psychiatrist by Rebecca Lawrence review – doctor turned patient

A brave memoir from a psychiatrist with severe mental illness that describes a failing system from within

theguardian.com

I am still obsessing over this bone development paper showing bone replacing cartilage and thinking about how this mirrors the evolutionary innovation of a bony skeleton replacing a cartilage body plan. Ontogeny recapitulates phylogeny. www.nature.com/articles/s41...

My latest post on what to expect for the NHS this winter open.substack.com/pub/christin... TLDR: looks likely we'll avoid a repeat of disastrous 2022/23 winter, but only by luck 1/6

What is winter looking like for the NHS?

Worrying signs in A&E for October but we are likely to avoid a repeat of the 2022 nightmare winter

open.substack.com

Me seeing all the healthcare/psych/MH types appear as followers/mutuals when ~80% of what I post is either unserious/fun or otherwise unrelated to the day job

a man with a mustache is sitting in a red car looking out the window .

Alt: a man with a mustache is sitting in a red car looking out the window .

media.tenor.com

Latest paper in Nature this week: an atlas integrating 36 single-cell datasets spanning 26 protocols for making neural #organoids Effort led by B. Treutlein, @fabiantheis.bsky.social and @graycamplab.bsky.social