AI meets AMP. Thinking about s strategy to produce it recombinantly. Bit need to overcome activity on the producer.

RSC Advances@rscadvances.rsc.org · last mo.

This recent article by Shrivastava and coworkers presents a new antimicrobial peptide to combat multidrug-resistant Pseudomonas aeruginosa bacteria for burn wound healing🦠 Read for free here: doi.org/10.1039/d6ra...

Landmarks in (Micro)Biology: 1943 - Luria&Delbrück 1952 - Hershey&Chase 1967 - Goulian et al. 1977 - Sanger et al. 2003 - Smith et al. Here's the latest bacteriophage landslide study. Thinking of it now, it probaly was to be expected. Still knocks me off my feet. www.science.org/doi/10.1126/...

Generative design of bacteriophages with genome language models

Many important biological functions arise not from single genes but from complex interactions encoded by entire genomes. We report the first generative design of complete bacteriophage genomes using g...

science.org

Plating marathon on a Sunday to help my PhD student Ömer assessing the culturable AMR reservoir in soil under different fertilization regimes. 4 antibiotics, 2 concs., 6 dilutions, 2 media. With replicates: 650 plates. And that‘s just 3 of 72 samples. No problem with a bit of good old skate punk 🤘

And then visited Naturkäserei Maucher, where bacteriocin producers ensure food safety. Finished the day with a nice BBQ. www.naturkaeserei-maucher.de

Thursday was a day off for the group. Connecting the topics of the group, we first went for a few km through Allgäu grasslands of high and low land-use intensity (subject of the TrophicHealth project for isolation of novel bacteriocins). www.uni-ulm.de/nawi/trophic...

Two brand new BioStat bioreactors set up in on our fermentation lab and for the first in full effect. The bacteriocins group at UUlm is now ready to produce antimicrobial and antiviral peptides with all barrels firing from shake flasks to 10l vessels.

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis #MolMicrobiol from Thorsten Mascher @spp2389.bsky.social, Rut Carballido-López and colleagues onlinelibrary.wiley.com/doi/10.1111/...

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis

Transcriptional profiling of the primary cell envelope stress response (CESR) of Bacillus subtilis exposed to a range of cell wall-targeting antimicrobials, combining RNAseq and high-resolution tilin...

onlinelibrary.wiley.com

Fluorescent labeling extended to 3 streptococcal species 🧫✨ @veeninglab.com & coll. benchmarked 5 proteins and developed multicolor cassettes enabling triple labeling—expanding tools for gene expression, cell dynamics & infection studies. 👉️ buff.ly/DFMXjE7

The Bacteriocins lab stocking up on tip boxes at the end of a long lab cleaning day. To make things a bit easier and tick the sustainability box, we‘re having a couple of Radler that were at half price in the cafeteria due to recently expired shelf life🤩

Just realized: @bacteriocins.bsky.social has 1001 followers😊. Thanks Bluesky 🙏. We will try to keep you updated on work by us and others on bacteriocins.

Already out a few days out but still worth saying: great work by Lisa Prigolovkin, PhD Student in the group of Marco Oldiges at Forschungszentrum Jülich, on accurate, automated quantification of lysostaphin: rdcu.be/e26kv Happy that my group, especially Christian Desiderato, were able to help a bit.

Day out with the group. First stop at the Museum für Brot und Kunst to see its current exhibition „Winzige Giganten“ (tiny giants) which includes pieces created by our very own PhD student Karo introducing our work on the impact of fertilization on the soil microbiome (project IMPALA)

As announced a few days ago, Rostand's first paper was accepted in Environmental Microbiology Reports. The paper is now online. Here is the link: enviromicro-journals.onlinelibrary.wiley.com/doi/full/10.... Huge thanks to the Baden-Württemberg Foundation for funding.

Impact of Fertilisation on the Bacterial Core Microbiome of Grassland Soils: Abundance in the Field and Growth In Vitro

Effects of different organic fertilisation regimes on the bacterial microbiome of grassland soil were analysed by 16S rRNA amplicon sequencing. Different fertilisation regimes led to distinct changes....

enviromicro-journals.onlinelibrary.wiley.com

Also today: I realized that we are at 993 followers. C'mon bluesky, get us over the hump to make it 1000.

Excellent day. Our very own PhD student Rostand successfully defended his thesis on the impact of organic fertilization on the soil microbiome of grassland ecosystems. Congratulations Rostand, well done.

Finally out: the first paper of our #IMPALA project on the impact of organic fertilization on microbiomes in grassland ecosystems. Here we analyse 16S amplicons. Soon to come #bacteriocin gene clusters in metagenomes of the same samples academic.oup.com/ismecommun/a...

Great meeting today at Bielefeld University to discuss progress and next steps in WP1 of our EU project #iCulture on production of antimicrobial peptides using biomass of marine macroalgae and the German microbe of the year C. glutamicum

🚨 New preprint klaxon 🚨 We characterised the structure of a PNGaseA superfamily member from Bifidobacterium bifidum LMG13195 and highlight its preference for N-glycan structures attached to a peptide, rather than to a native or denatured protein 💫 @imibirmingham.bsky.social

PNGaseA-mediated N-glycan stripping from peptides by infant-derived Bifidobacterium bifidum

N-glycans are highly common sources of nutrition for human colonic-dwelling bacteria. These microbes have evolved a several methods to remove N-glycans from proteins; herein we describe the biochemica...

biorxiv.org

So true. And if you want to hear how we try to produce #bacteriocins and other antimicrobial/antiviral peptides using a biotech workhorse organism, come to my talk tomorrow at 11:30h in the Biotechniology for Health Session (Amber 1&2 hall) of #FEMS2025. Or to Poster 395.16P on Thursday.

FEMS@femsmicro.org · last yr.

Antimicrobial resistance is a public health threatwhich urges us to find alternative treatments. In this #FEMSmicroBlog, Mariella Careaga discusses how scientists are exploring quorum quenching as a promising strategy to combat drug-resistant bacteria. #MicrobiologyIsEverywhere buff.ly/IwwSLIO

Ready, set, go for the opening plenary session of #FEMS2025

Bacteriocins.bsky.social will be attending #FEMS2025. Found out yesterday that my abstract was selected for a talk and poster 😱. All Emails were moved to Spam for some reason 🤯. Will do my best to give a convincing presentation on recombinant production of #bacteriocins

www.quantamagazine.org/how-a-biofil...

How a Biofilm’s Strange Shape Emerges From Cellular Geometry | Quanta Magazine

Micro decisions can have macro consequences. A soft matter physicist reveals how interactions within simple cellular collectives can lead to emergent physical traits.

quantamagazine.org

Fantasic digital 3D model of The Ulmer Münster. Highest church tower in Germany and the world (as long as Sagrada Familia in Barcelona remains unfinished) sketchfab.com/3d-models/ul...

Ulmer Münster - Download Free 3D model by LAD BW (@ladbw)

Ulmer Münster Ulm (Stadt Ulm) Interaktive Karte aller Modelle Fotos: Martin Schaich 2020 (c) Landesamt für Denkmalpflege im Regierungspräsidium Stuttgart - Ulmer Münster - Download Free 3D model b...

sketchfab.com

www.nature.com/articles/s41...

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature

A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

nature.com

Sailing, Sampling, Sequencing - Edition 2025

Question in the recent microbiology exam: What does the abbreviation „LUCA“ stand for? Answer of one of the students: „last useless common ancestor“ 🤷‍♂️

Once again my old love bifidobacteria prove to be important for proper development of the immune system and may help against reduced vaccine responses indiced by antibiotics www.nature.com/articles/s41...

Bifidobacteria support optimal infant vaccine responses - Nature

Neonatal antibiotic use is shown to reduce immune response to infant vaccines, accompanied by reduced abundance of Bifidobacteria in the gut microbiota, with experiments in mice indicating that probio...

nature.com

Great work be the @delafuentelab.bsky.social using Andersonin-D1, an antimicrobial peptide of a frog, as basis to generate potent synthetic peptide antimicrobials by structure-guided design www.cell.com/trends/biote...

Frog-derived synthetic peptides display anti-infective activity against Gram-negative pathogens

Synthetic peptides, inspired by the natural defenses of amphibians, demonstrate selective activity against Gram-negative pathogens while sparing the gut microbiota and Gram-positive strains. Rationall...

cell.com

RIPP family of lasso peptides act by binding to the ribosome and inhibition of protein synthesis www.nature.com/articles/s41...

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature

A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

nature.com

Here’s to all the ladies in science out there and in my lab. You run the show. www.un.org/en/observanc...

International Day of Women and Girls in Science | United Nations

The purpose of the day is to achieve full and equal access to and participation in science for women and girls.

un.org