Pilar Domingo-Calap

@pilardomingoc.bsky.social

PI Environmental and Biomedical Virology Lab #EnBiVirLab Universitat de Valencia-CSIC @VLCphagehunters Co-founder and CSO at Evolving Therapeutics @evolving_spain Spain

Very proud of @celiaferriolg.bsky.social! Amazing experimental evolution for phage optimization and for host range expansion, allowing us to understand the evolvability of phage RBPs. This work is part of her PhD project at the #EnBivirLab @i2sysbio.es @uv.es @ccbiologiquesuv.bsky.social

PLOS Biology@plosbiology.org · 9mo ago

Capsule diversity limits #phage host range by affecting receptor-binding protein (RBP) interactions in capsulated #bacteria. @pilardomingoc.bsky.social &co show that generalist phages evolve host range via RBP mutation & recombination, but specialists remain stable @plosbiology.org 🧪 plos.io/48nvOqY

Graphic representation of the recombination events in the Sugarlandvirus I and J variants. Top left: Representation of the variants isolates in the different strains in the three lines. Genome fragments of each parent are represented in a different color. Regions with the most abundant recombination events are marked and associated with a schematic representation of the functional annotation and intergenomic similarity between the two parental phages. Bottom left: 3D folding of the RBPγ. The consensus recombinant region, which is associated with the infection of the K-type 47, is represented in light orange. Variable positions detected in the protein sequence alignment of the variants are represented as hot pink spheres. The table indicates the percentage of identity of the parental protein sequences in three protein regions limited by the amino acids indicated. Right: Transmission electron microscopy (TEM) image of Klebsiella myoviruses artificially coloured, showing their characteristic contractile tails and icosahedral capsids. Image acquired by the Environmental and Biomedical Virology group (Institute for Integrative Systems Biology, Universitat de València-CSIC).

👉 EVOLVING THERAPEUTICS, s'encarrega de la prevenció, diagnòstic i tractament de bacteris patògens resistents a antibiòtics amb una metodologia basada en fags. Cofundada i dirigida per @pilardomingoc.bsky.social , exalumna i professora de la Facultat. ▶️ go.uv.es/Is1CpTJ

Envolving Therapeutics (Spin-off de la Facultat) | VDS 2025

YouTube video by Facultat de Ciències Biològiques

youtube.com

Proud to be included in the top 2% World Ranking of Scientist @stanforduniversity.bsky.social, and to be the only woman at my Faculty in 2024 @ccbiologiquesuv.bsky.social. Thanks to my lab #EnBiVirLab @i2sysbio.es @uv.es @csic.es, all collaborators, and special thanks to all #VLCPhageHunters!

Facultat de Ciències Biològiques de la Universitat de València@biologiques-uv.bsky.social · 10mo ago

🗞️Investigadors de la @ccbiologiquesuv.bsky.social al Stanford University - World Ranking of Scientists dels més influents del món. 🖇️Més informació: links.uv.es/6egolOY

🗞️ Aquesta matinada El País ha publicat aquest article sobre com els fags, virus que es poden utilitzar per combatre bacteris resistents que no tenen tractament, han salvat la vida d'una pacient. I d'això a Mètode ja va parlar la viròloga @pilardomingoc.bsky.social

Los fagos le salvan la vida a Irene, que recibió y rechazó cuatro pulmones trasplantados

Científicos y médicos se sirven de estos virus que atacan a las bacterias para eliminar una infección resistente a los antibióticos que afectó a una paciente valenciana durante 30 años

elpais.com