Kruno Vukušić
@krunovuk.bsky.social
Senior postdoc at Tolić lab, RBI, Croatia. Studying cell division mechanisms. Biology and biophysics enthusiast.
Thanks, @focalplane.bsky.social!
FocalPlane @focalplane.bsky.social · 7mo ago🔬🔦Our latest imaging spotlight is from Kruno Vukušić @krunovuk.bsky.social & Iva Tolić @ivatolic.bsky.social, describing their research using multi-scale live lattice light-sheet microscopy & super-resolution microscopy to interrogate the earliest steps of chromosome congression.
Chromosomes stuck behind the spindle are ticking time bombs for aneuploidy. We uncovered a mechanical rescue mechanism where microtubule pivoting repositions these high-risk chromosomes! Out last week in @natcomms.nature.com, here's a thread 🧵 shorturl.at/OD89x
🔬🔦Our latest imaging spotlight is from Kruno Vukušić @krunovuk.bsky.social & Iva Tolić @ivatolic.bsky.social, describing their research using multi-scale live lattice light-sheet microscopy & super-resolution microscopy to interrogate the earliest steps of chromosome congression.
Imaging spotlight: Initiation of chromosome congression deconstructed by multi-scale live lattice light-sheet and super-resolution microscopy - FocalPlane
Imaging spotlight: Initiation of chromosome congression deconstructed by multi-scale live lattice light-sheet and super-resolution microscopy - News
focalplane.biologists.com
When our institute’s legendary PR team tells our science story 🤩 @krunovuk.bsky.social @erc.europa.eu www.nature.com/articles/s41... www.nature.com/articles/s41...
And now… part two of our twin papers on how chromosomes find their place before division! Led by @krunovuk.bsky.social at @institutrb.bsky.social, out in @natcomms.nature.com! doi.org/10.1038/s414... doi.org/10.1038/s414... Missed the thread on the first paper? Catch up: bsky.app/profile/ivat...
Our latest research in collaboration with @nilssonlab.bsky.social, @andrea-musacchio.bsky.social and Mathieu Bollen reveals a new regulatory strategy employed by cells to control PP1 in mitosis. Check it out in @currentbiology.bsky.social www.sciencedirect.com/science/arti...
Polo kinase inhibits protein phosphatase 1 to promote the spindle assembly checkpoint and prevent aneuploidy
Protein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains i…
sciencedirect.com
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com doi.org/10.1038/s414... doi.org/10.1038/s414...
🚀Ever wondered if there's a universal rule of spindle scaling across eukaryotes? Turns out, there is! Our study reveals an evolutionarily conserved principle driven by a surprising factor: chromosome crowding. 🧵👇 shorturl.at/MmPNr