Very happy to see our work highlighted by @natcellbio.nature.com. A great team effort and a fascinating example of how a simple physical principle can connect mitosis across eukaryotes! @lgudlin.bsky.social, @krunovuk.bsky.social, @kopslab.bsky.social

Nature Cell Biology@natcellbio.nature.com · 3w ago

☕ @lgudlin.bsky.social, @krunovuk.bsky.social, Novak et al propose spindle scaling in response to chromosome crowding consistent across eukaryotes; metaphase plate width scales with genome size following a power law with an exponent of ~1/3. @ivatolic.bsky.social www.nature.com/articles/s41...

☕ @lgudlin.bsky.social, @krunovuk.bsky.social, Novak et al propose spindle scaling in response to chromosome crowding consistent across eukaryotes; metaphase plate width scales with genome size following a power law with an exponent of ~1/3. @ivatolic.bsky.social www.nature.com/articles/s41...

Power-law scaling of mitotic spindles with genome sizes across eukaryotes is driven by chromosome crowding - Nature Cell Biology

Gudlin, Vukušić, Novak and colleagues propose spindle scaling in response to chromosome crowding consistent across eukaryotes. They show that metaphase plate width scales with genome size following a ...

nature.com

Spindle squad #SpindleCroatia2026 #Dubrovnik www.phy.pmf.unizg.hr/~mitosis/

Thanks, @focalplane.bsky.social!

FocalPlane @focalplane.bsky.social · 9mo ago

🔬🔦Our latest imaging spotlight is from Kruno Vukušić @krunovuk.bsky.social & Iva Tolić @ivatolic.bsky.social, describing their research using multi-scale live lattice light-sheet microscopy & super-resolution microscopy to interrogate the earliest steps of chromosome congression.

Chromosomes stuck behind the spindle are ticking time bombs for aneuploidy. We uncovered a mechanical rescue mechanism where microtubule pivoting repositions these high-risk chromosomes! Out last week in @natcomms.nature.com, here's a thread 🧵 shorturl.at/OD89x

🔬🔦Our latest imaging spotlight is from Kruno Vukušić @krunovuk.bsky.social & Iva Tolić @ivatolic.bsky.social, describing their research using multi-scale live lattice light-sheet microscopy & super-resolution microscopy to interrogate the earliest steps of chromosome congression.

Imaging spotlight: Initiation of chromosome congression deconstructed by multi-scale live lattice light-sheet and super-resolution microscopy - FocalPlane

Imaging spotlight: Initiation of chromosome congression deconstructed by multi-scale live lattice light-sheet and super-resolution microscopy - News

focalplane.biologists.com

When our institute’s legendary PR team tells our science story 🤩 @krunovuk.bsky.social @erc.europa.eu www.nature.com/articles/s41... www.nature.com/articles/s41...

And now… part two of our twin papers on how chromosomes find their place before division! Led by @krunovuk.bsky.social at @institutrb.bsky.social, out in @natcomms.nature.com! doi.org/10.1038/s414... doi.org/10.1038/s414... Missed the thread on the first paper? Catch up: bsky.app/profile/ivat...

Our latest research in collaboration with @nilssonlab.bsky.social, @andrea-musacchio.bsky.social and Mathieu Bollen reveals a new regulatory strategy employed by cells to control PP1 in mitosis. Check it out in @currentbiology.bsky.social www.sciencedirect.com/science/arti...

Polo kinase inhibits protein phosphatase 1 to promote the spindle assembly checkpoint and prevent aneuploidy

Protein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains i…

sciencedirect.com

Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com doi.org/10.1038/s414... doi.org/10.1038/s414...

🚀Ever wondered if there's a universal rule of spindle scaling across eukaryotes? Turns out, there is! Our study reveals an evolutionarily conserved principle driven by a surprising factor: chromosome crowding. 🧵👇 shorturl.at/MmPNr