Single-cell transcriptomics uncovers endothelial progenitor-like remodelling driving human coronary atherosclerosis progression - Nature Cell Biology

Yao, Li, Gai et al. profile normal coronary artery and early and advanced coronary atherosclerosis samples from humans using single-cell transcriptomics and identify a progenitor-like endothelial subt...

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Decoding stage-specific functions of PRC2 in early embryogenesis uncovers roles in preimplantation development and primordial germ cell fate - Nature Cell Biology

Zhou, Wang et al. dissect the role of PRC2 in early embryogenesis through inducible degradation of EED, a core PRC2 subunit, and report that PRC2 is required for proper maternal-to-zygotic transition ...

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CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell Biology

Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.

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Evolutionarily conserved short linear motifs drive actin filament binding - Nature Cell Biology

Paraschiakos, Yuan et al., using a computational pipeline, identify the short linear actin filament-binding motif (SFM) as an evolutionarily conserved actin filament-binding motif present in 103 human...

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Cell surface liposome binding (CLiB) allows lipid-binding probe engineering via high-throughput screening - Nature Cell Biology

Nishimura et al. develop a platform named cell surface liposome binding (CLiB), which allows the high-throughput monitoring of protein–lipid interactions and can be used to design lipid-binding probes...

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An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons - Nature Cell Biology

Liu, Huang, Shen, Shao, Jing and collaborators combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN...

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An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons - Nature Cell Biology

Liu, Huang, Shen, Shao, Jing and collaborators combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN...

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Cis and trans regulatory mechanisms of extrachromosomal DNA segregation - Nature Cell Biology

Xie et al. demonstrate that extrachromosomal DNA tethering to mitotic chromosomes is in part mediated by H3K27ac-marked chromatin, associated chromatin binders and transcription-associated cofactors.

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Mediator subunit MED4 enforces metastatic dormancy in breast cancer - Nature Cell Biology

Bae et al. identify MED4 as a regulator of tumour dormancy from a genome-wide CRISPR screen, and show that loss of MED4 alters the enhancer landscape and induces extracellular matrix remodelling to dr...

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Lysosome-derived methylated arginine is a signalling metabolite controlling the lipidome - Nature Cell Biology

Nguyen et al. show that accumulation of dimethylarginine in lysosomes in disease models is associated with lipotoxicity and lipid droplet abundance.

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Integrated stress response couples mitochondrial fitness with lineage reprogramming to drive cancer evolution - Nature Cell Biology

Diao, Zou et al. demonstrate that activation of the integrated stress response drives lineage dedifferentiation and tumour progression in lung adenocarcinoma, associated with aberrant mitochondrial fu...

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Stem cell-based embryo models

Because of their ability to simulate certain aspects of embryonic development, stem cell-based embryo models can be a promising tool in our efforts to better ...

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ERO1a fosters glioblastoma aggressiveness and metabolic flexibility by regulating mitochondria-associated membrane dynamics - Nature Cell Biology

Bassot, Violy, Gorka, Cigalotto and colleagues identify ERO1a as a mitochondria-associated membrane protein that regulates calcium flux and mitochondria bioenergetics, which may be potentially targete...

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TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells - Nature Cell Biology

Wang, Liang and colleagues show that the TEAD1 transcription factor can organize micrometre-sized nuclear biomolecular condensates independently of active transcription. TEAD1 condensates may act as d...

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DRP1 and MID49 co-diffusion scans mitochondria for fission - Nature Cell Biology

Zollo et al. examine DRP1 behaviour at mitochondria: DRP1 diffuses along mitochondria in helical-like patterns influenced by MID49/MID51, scanning the organelle surface and stalling at preconstricted ...

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Mitochondria–ER contacts function as an iron supply hub - Nature Cell Biology

Oshio, Shiiba and colleagues show that HMOX2, which catalyses haem degradation, supplies haem-derived iron to mitochondria at ER–mitochondria contact sites in a process mediated by the mitochondrial u...

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Long-range mutual activation establishes Rho and Rac polarity during cell migration - Nature Cell Biology

De Belly et al. show Rac induces membrane-tension-mediated mTORC2 activation to stimulate long-range Rho activation. Meanwhile, Rho-mediated contractility and blebbing at the opposite side of the cell...

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Nucleophagy removes cytotoxic trapped PARP1 - Nature Cell Biology

Hoslett et al. show that trapped PARP1 is cleared from the nucleus by nucleophagy involving the autophagy receptor TEX264 and p97. Inactivation of nucleophagy resensitizes acquired resistance of BRCA1...

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Relative tension shapes embryos - Nature Cell Biology

Nature Cell Biology - Relative tension shapes embryos

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Stem cell-based embryo models

Because of their ability to simulate certain aspects of embryonic development, stem cell-based embryo models can be a promising tool in our efforts to better ...

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Learning from stem cell-based embryo models - Nature Cell Biology

Efforts to construct stem cell-based embryo models are thriving, with numerous potential implications for basic and translational research. We now introduce a Collection of articles that highlight rec...

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Diffusing caveolin-1 scaffolds regulate mechanosignalling - Nature Cell Biology

Mani, Tardif, Rossier et al. show that mechanical stress triggers caveolin-1 release from caveolae, enabling its diffusion in the plasma membrane and interaction with signalling effectors to regulate ...

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Developmental chronology of mouse embryo from 2-cell stage through birth - Nature Cell Biology

Cao, Lin, Feng, Chen, Wu and colleagues develop a mouse developmental single-cell atlas covering 2-cell stage through to birth.

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ISSCR 2026

An international gathering of the brightest minds in stem cell research and regenerative medicine across disciplines. Join us for the 2026 ISSCR Annual Meeting 8-11 July 2026 in Montréal, Canada.

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Segmental specification of the human female fetal reproductive tract revealed by spatiotemporal dynamics - Nature Cell Biology

He, Wang, Ding and colleagues report a transcriptomic atlas of human female reproductive tract segments from fetuses at gestational weeks 10 to 25.

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Transcription-independent induction of rapid-onset senescence is integral to healing - Nature Cell Biology

Valdivieso, Rozmaric et al. show that wounding rapidly induces a senescent state in skin cells involving p21 protein induction, without the need for new transcription. These senescent cells are benefi...

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A transport-independent role for SLC25A12 in mitochondrial stress signalling - Nature Cell Biology

Jiang et al. show that SLC25A12 interacts with the mitochondrial protease OMA1, enabling activation of integrated stress response during mitochondrial damage. This role is independent of SLC25A12’s tr...

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