Tessera
Folgen

George Caputa

@curiousdrgeorge.bsky.social

senior editor at Nature for cellular & mitochondrial metabolism, metabolic physiology, cardiology, vascular biology, clinical science. All views my own. nerdy | queer | they/m

10 Posts2888 Follower37 Folgt
George Caputa@curiousdrgeorge.bsky.social · 2y ago

For single cell foundation model fans, Raul Rabadan & colleagues just published GET in @nature.com, which trained on chromatin accessibility data to predict transcription factor interactions/motifs, cis-regulatory elements, & gene expression from 213 human cell types www.nature.com/articles/s41...

A foundation model of transcription across human cell types - Nature

A foundation model learns transcriptional regulatory syntax from chromatin accessibility and sequence data across a range of cell types to predict gene expression and transcription factor interactions...

nature.com

George Caputa@curiousdrgeorge.bsky.social · 2y ago

First 2025 metabolism publication in @nature.com is from Michael Karin's group, finding that metabolic hepatosteatosis promotes senescence of hepatocytes, but is bypassed through transcriptional inactivation of FBP1, a novel gatekeeper against hepatocellular carcinoma www.nature.com/articles/d41...

Paradoxical link between senescent cell state and liver cancer resolved

DNA damage caused by a high-fat diet can increase the risk of tumour formation in the liver.

nature.com

Barbara Marte@barbmarte.bsky.social · 2y ago

a great opportunity to join the Nature team: we're looking for a neuroscience editor, ideally with a strong record in systems neuro: springernature.wd3.myworkdayjobs.com/SpringerNatu...

Associate or Senior Editor, Nature

Job Title: Associate or Senior Editor, Nature Locations: New York or Berlin (Hybrid working model) Application Deadline: December 15th, 2024 About Springer Nature Group Springer Nature opens the doors...

springernature.wd3.myworkdayjobs.com

Cameron McAlpine@mcalpinelab.bsky.social · 2y ago

We are delighted to share our latest findings in @natureportfolio.bsky.social! We describe cardiogenic regulation of sleep after cardiac injury. www.nature.com/articles/s41...

Myocardial infarction augments sleep to limit cardiac inflammation and damage - Nature

Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...

nature.com

George Caputa@curiousdrgeorge.bsky.social · 2y ago

Sleeping is one of my fav activities. Very excited that we got to share this study by @mcalpinelab.bsky.social showing that cardiac inflammation after a heart attack dictates sleep patterns and promotes healing/recovery. www.nature.com/articles/s41...

Myocardial infarction augments sleep to limit cardiac inflammation and damage - Nature

Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...

nature.com

George Caputa@curiousdrgeorge.bsky.social · 2y ago

A great study by @lydialynch.bsky.social 's group showing that IL-17 producing immune cells in adipose dictate the circadian rhythm of that tissue and orchestrate de novo lipogenesis and systemic metabolism www.nature.com/articles/s41...

Rhythmic IL-17 production by γδ T cells maintains adipose de novo lipogenesis - Nature

Innate IL-17-producing T cells—in particular, adipose γδ17 T cells—are enriched in molecular-clock genes, and the circadian expression of IL-17A and RORγt by these cells has a role in maintaining loca...

nature.com

George Caputa@curiousdrgeorge.bsky.social · 2y ago

Very cool paper by Craig Thompon's group spearheaded by @keunwooryu.bsky.social identifying distinct subpopulations of oxidative and reductive mitochondria. Can't wait to see everyone check their fav cell types for these populations! www.nature.com/articles/s41...

Cellular ATP demand creates metabolically distinct subpopulations of mitochondria - Nature

Mitochondria are able to maintain two competing metabolic pathways—oxidative phosphorylation and the reductive synthesis of proline and ornithine—by generating two mitochondrial subpopulations that ar...

nature.com

George Caputa@curiousdrgeorge.bsky.social · 2y ago

First post! Didn't see this study on @bsky.app. From @zgerharthines.bsky.social group identifying neuronal NK2R as a regulator of feeding/hunger & energy expenditure, and demonstrating the efficacy of a small molecule agonist in non-human primates for weight loss. www.nature.com/articles/s41...

NK2R control of energy expenditure and feeding to treat metabolic diseases - Nature

In mouse and nonhuman primate models, treatment with selective, long-acting neurokinin 2 receptor agonists aids weight loss by suppressing appetite and increasing energy expenditure, as well as b...

nature.com

vonMeyenn Lab @ ETH Zurich@vonmeyennlab.bsky.social · 2y ago

🧬 New in @Nature: Our team found that fat cells keep a “memory” of their previous obese state even after weight loss, helping explain why maintaining weight loss is so challenging. Excited to share this work!! www.nature.com/articles/s41...

Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature

Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

nature.com