My lab is expanding and I am looking for postdocs to join our team! If you are driven to pursue impactful science, have an interest in neuro-cardio-immunology, and want to live in vibrant NYC (with subsidized housing), please reach out! Lab website: labs.icahn.mssm.edu/mcalpinelab/

New online! Sleep and exercise can limit clonal haematopoiesis clone expansion and reduce associated atherosclerosis #CardioSky

Sleep and exercise can limit clonal haematopoiesis clone expansion and reduce associated atherosclerosis

Nature Reviews Cardiology, Published online: 22 June 2026; doi:10.1038/s41569-026-01318-3A study in Nature reports that in mice, healthy lifestyle behaviours, including exercise and uninterrupted sleep, can limit clone expansion in clonal haematopoiesis and promote the phenotypic reprogramming of clonal haematopoiesis mutant cells, thereby reducing the risk of atherosclerosis.

dlvr.it

We are happy to share another paper from the lab! Led by Lena Gaebel, using unconditioned adoptive cell transfer and congenic tracking, we show that Tet2 or Jack2 clonal hematopoiesis do not modify murine tauopathy. journals.sagepub.com/doi/10.1177/...

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Nature research paper: Mutation-dependent responses to sleep and exercise in clonal haematopoiesis go.nature.com/4op9KDO

Mutation-dependent responses to sleep and exercise in clonal haematopoiesis - Nature

Sleep and exercise can slow clonal haematopoiesis and limit mutant cell-driven atherosclerosis.

go.nature.com

We are delighted to share the latest findings from the lab in Nature! Led by Dr. Teresa Gerhardt, we report mutation-dependent effects of sleep and exercise on clonal hematopoiesis (CH) and its associated atherosclerosis. www.nature.com/articles/s41...

Mutation-dependent responses to sleep and exercise in clonal haematopoiesis - Nature

Sleep and exercise can slow clonal haematopoiesis and limit mutant cell-driven atherosclerosis.

nature.com

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀 Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities. Sign up. Stay informed. Join the movement: www.nycures.org/

New @science.org A peptide released from white blood cells, directed against bacteria, can also poke holes in the membrane of heart muscle cells and induce a lethal arrhythmia (ventricular tachycardia). In the mouse model. www.science.org/doi/10.1126/...

Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia

Ventricular tachycardia disrupts the heart’s coordinated pump function, leading to sudden cardiac death. Neutrophils, which are recruited in high numbers to the ischemic myocardium, promote these arrh...

science.org

It was a pleasure to present data from the lab at #ESCcongress! There has been a great focus on neuronal and immune contributions to CVD.

I am honored to receive this award! It is a testament to the lab and their hard work!

The Friedman Brain Institute@sinaibrain.bsky.social · last yr.

✨CONGRATULATIONS @mcalpinelab.bsky.social on being honored w/ the Dr. Harold & Golden Lamport Basic Research Award for demonstrating exceptional promise for making significant, long-term contributions to biomedical research!🎉 @mountsinainyc.bsky.social @sinaiimmuno.bsky.social

www.nature.com/articles/s41...

Mitochondrial origins of the pressure to sleep - Nature

Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

nature.com

💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s41... #OpenAccess at @Nature @CNIC_CARDIO #CVD #immunosky #cardiosky #microbiomesky

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

nature.com

What happens in Vagus🎰... find out on July 29th at 10am when you join host Dr. Sarah Stanley as she welcomes University of Virginia's Dr. John Campbell @augcsoup.bsky.social to the #BrainBodyResearchInstitute Seminar Series @mountsinainyc.bsky.social. Register👉 mountsinai.zoom.us/webinar/regi...

Very much looking forward to having Tim as a colleague and lab neighbor! Many exciting collaborations to come!

Tim Kenny@timckenny.bsky.social · last yr.

Thrilled to announce that I will be joining the @mountsinaicvri.bsky.social at the Icahn School of Medicine at Mount Sinai as an Assistant Professor in January! My laboratory will focus on nutrient transport and cellular metabolism in physiology and disease.

Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia www.nature.com/articles/s41...

Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia - Nature Immunology

McGavern and colleagues identified a CD8+ T cell population that expresses GZMK in ʽtau-richʼ brains, where it may play a protective role against neurodegeneration.

nature.com

We are proud to announce that five CVRI faculty members - Fil Swirski (@filswirski.bsky.social), Mandy van Leent, Cameron McAlpine (@mcalpinelab.bsky.social), Maria Noval, and Sikander Hayat - will be presenting their groundbreaking work at Atherosclerosis GRC this Friday, June 27th.

Check out our review on neural mechanisms in cardiovascular health and disease! 👇

Fil Swirski@filswirski.bsky.social · last yr.

Happy to share a new review: Neural Mechanisms in Cardiovascular Health and Disease | Circulation Research www.ahajournals.org/doi/full/10.... Part of a series on Inter-organ communication! Great teamwork: KA Ziegler, S Engelhardt, D Carnevale, C McAlpine, T Guzik, S Dimmeler!

A wonderful perspective that includes the idea of cardiovascular disease as a stressor that induces sleep.

Eric Topol@erictopol.bsky.social · last yr.

Experimental evidence that post-stress sleep has the capacity to build resilience cell.com/neuron/fullt...

We are looking for a scientist to join the growing Brain-Body Research Institute at Mount Sinai! Consider joining a dynamic fundamental and translational team investigating inter-organ physiology and communication between the brain and periphery. Feel free to reach out if you have any questions.

Scott Russo@scottrussophd.bsky.social · last yr.

The Brain-Body Research Institute @IcahnMountSinai is hiring an Associate Director to build clinical and translational research in brain-body sciences. See ad here: neuroscience.mssm.edu/pdf/Brain-Bo.... @sinaibrain.bsky.social @sinaiimmuno.bsky.social @brainbodylab.bsky.social

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —from decades of NIH funded research www.nejm.org/doi/full/10.... @nejm.org www.nejm.org/doi/full/10.... www.nytimes.com/2025/05/15/h...

Exciting news! 🎉 Matthias Nahrendorf, MD, PhD, has been named Editor-in-Chief of #JACCBTS! A leader in CV research, imaging & immunology, he brings a passion for collaboration & scientific excellence. Please join us in welcoming him to this important role 👏👏 👏 📎: www.jacc.org/announcement...

Very excited to share part of my postdoctoral work from the @tjryan.bsky.social lab, out now in @nature.com. Here, my brilliant co-author @andreamunozz.bsky.social and I explored the link between memory engrams and whole-body metabolism. A thread: 🧵 www.nature.com/articles/s41...

Cold memories control whole-body thermoregulatory responses - Nature

Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed betw...

nature.com

We are thrilled to share the latest from the lab! We demonstrate that multi-organ MCSF-dependent myelopoiesis is dynamic in MS and is manipulated by lifestyle to influence disease severity and neuroinflammation. Big congrats to the whole team! www.nature.com/articles/s41...

Myelopoiesis is temporally dynamic and is regulated by lifestyle to modify multiple sclerosis - Nature Communications

Myeloid cells contribute to the etiology of multiple sclerosis (MS), but the dynamics of myelopoiesis during disease progression is still unclear. Here the authors show, in both mouse models and clini...

nature.com

Excited to announce an official scientific statement from the @americanheart.bsky.social! "Multidimensional Sleep Health: Definitions and Implications for Cardiometabolic Health" Special thanks to @m-pst-ongephd.bsky.social www.ahajournals.org/doi/10.1161/...

A Huge Congratulations to @scottrussophd.bsky.social 👉 named Director of the NEW #BrainBody Research Institute. The Institute will focus on holistic approaches to science & medicine to gain a better understanding of how the brain & body interact in health & disease. Again, Congratulations Scott!👏💯

📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social

Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis

Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.

science.org

Sleep duration/timing and glucose regulation in over 1100 people with 14-day continuous glucose sensor jamanetwork.com/journals/jam...

Sleep and Long-Term Risk of Type 2 Diabetes in Women With Gestational Diabetes

This cohort study assesses whether sleep duration and quality are associated with incidence of type 2 diabetes among women with a history of gestational diabetes who participated in the Nurses’ Health...

jamanetwork.com

Better sleep quality could reduce inflammation and improve health outcomes in obesity doi.org/10.1093/jimm... @jimmunol.bsky.social

Impact of sleep deprivation on monocyte subclasses and function

Abstract. The relationship between sleep deprivation, obesity, and systemic inflammation is a critical area of investigation due to its significant impact

doi.org

1/4 I am very pleased to share this new manuscript, “A crucial role for the cortical amygdala in shaping social encounters”, led by 2 spectacular postdocs, Dr. Tony Aubry who is on the job market, and coauthor @neuromanonyc.bsky.social Read it here: www.nature.com/articles/s41...

A crucial role for the cortical amygdala in shaping social encounters - Nature

The posterolateral cortical amygdala and other connected brain regions have a key role in mediating the transition from investigative to aggressive behaviour in male mice.

nature.com

Check out this beautiful image called "Sleepy Aorta" from Jake, a student in the lab! This is an immunofluorescent image of atherosclerosis in the aortic root of a mouse with poor sleep. Give the post a ❤️ to vote for the #ArtoftheBrain contest! ❤️↔️🧠

The Friedman Brain Institute@sinaibrain.bsky.social · 2y ago

How important is it to get enough sleep? In the McAlpine Lab's Walter Jacob's image "Sleepy Aorta", immunofluorescence staining captures the immense cardiovascular inflammation following months of poor sleep. @mcalpinelab.bsky.social VOTE NOW for #ArtoftheBrain Image #3 👉 Most 💚's wins!

In medical school in the 1980s, we were taught that depression was an unpleasant and unwanted side effect of having a heart attack. But what if it is a healthy physiological response to help you heal by lowering demand on your heart? www.nature.com/articles/s41... | @natureportfolio.bsky.social

Myocardial infarction augments sleep to limit cardiac inflammation and damage - Nature

Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...

nature.com