Very excited to be traveling back to the USA for the first time since the end of my postdoc with Ben Cravatt in 2017. It is going to be a big one with 2 conferences, 4 department visits and 6 talks over the next two weeks. Looking forward to a great (and probably also exhausting) trip. (1/5)

Tomorrow, we will have the 6th Virtual ChemBioTalks with an amazing line-up of speakers. We are very much looking forward to welcoming you to this event! There is still a chance to register for free: events.zoom.us/ev/Ag... #ChemSky #ChemBio #Science #AnywhereChem Chemistry Europe

I am very much looking forward to the 6th Virtual @chembiotalks.bsky.social tomorrow. You can still register for free: events.zoom.us/ev/Ag1AUcW3n... Which speakers are you most looking forward to? #ChemBio #ChemSky #AnywhereChem #Science

Virtual ChemBioTalks@chembiotalks.bsky.social · 2w ago

Tomorrow, we will have the 6th Virtual ChemBioTalks with an amazing line-up of speakers. We are very much looking forward to welcoming you to this event! There is still a chance to register for free: events.zoom.us/ev/Ag... #ChemSky #ChemBio #Science #AnywhereChem Chemistry Europe

Get to know LED3 member @sebastianpomplun.bsky.social in his interview in the #MedChemBioConversations series of the @euromedchem.bsky.social. www.efmc.info/medchemwatch... #ChemSky #ChemBio #DrugDiscovery

Great to see our colleague @sebastianpomplun.bsky.social from the @led3hub.bsky.social highlighted in the #MedChemBioConversations series by @euromedchem.bsky.social. Check out the interview to learn more about him and his science. www.efmc.info/medchemwatch... #ChemSky #ChemBio #DrugDiscovery

New @biorxivpreprint.bsky.social from the group of @sebastianpomplun.bsky.social of our LED3 hub! 𝐏𝐑𝐎𝐗𝐈𝐍𝐀𝐔𝐓: 𝐀𝐧 𝐀𝐮𝐭𝐨𝐦𝐚𝐭𝐢𝐨𝐧 𝐏𝐥𝐚𝐭𝐟𝐨𝐫𝐦 𝐟𝐨𝐫 𝐑𝐚𝐩𝐢𝐝 𝐇𝐢𝐭-𝐭𝐨-𝐃𝐞𝐠𝐫𝐚𝐝𝐞𝐫 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 www.biorxiv.org/content/10.6... #ChemBio #ChemSky #DrugDiscovery #Degrader #TPD @leidenscience.bsky.social

Interesting @biorxivpreprint.bsky.social from the group of @sebastianpomplun.bsky.social with first author @seanmckenna.bsky.social. They combine Self-encoded libraries with automated synthesis to obtain a workflow for hit discovery, SAR and degrader development. www.biorxiv.org/content/10.6...

PROXINAUT: An Automation Platform for Rapid Hit-to-Degrader Discovery

Massive library-based platforms enable rapid early hit discovery, yet subsequent hit resynthesis and validation remain major bottlenecks in drug discovery. This delay is amplified when optimizing hits...

biorxiv.org

It was great to host Christian Hackenberger yesterday for a very well attended @led3hub.bsky.social Lecture. He gave amazing insights into the synthesis of highly efficacious antibody-drug conjugates as well as into intracellular delivery of proteins. (1/13) #DrugDiscovery #ChemSky #ChemBio #ADC

We are very happy that Christian Hackenberger visited us yesterday for the first LED3 Lecture of the new academic year in front of a full lecture hall. He talked about "P5-labeling to Generate Electrophilic Probes and Highly Efficacious Antibody-Conjugates". #DrugDiscovery #ADC #ChemBio #ChemSky

🚀 Launching PROXINAUT: An Automation Platform for Rapid Hit-to-Degrader Discovery Can we go directly from library-based hit discovery to validated ligands, SAR and functional protein degraders within a single automated workflow? 📄 Find out through our preprint on bioRxiv: doi.org/10.64898/202...

Are you excited about cutting-edge Chemical Biology? Next week on September 29th, the 6th Virtual ChemBioTalks will happen with an exciting program of world-leading scientists! You can still register for free: events.zoom.us/ev/Ag... (1/4)

Due to force majeure we have a change in our speaker program. We are very thankful that @dirktrauner.bsky.social agreed to give a keynote lecture on "Designing Molecules to Restore Human Vision and Alleviate Pain". If you have not registered yet, do so for free: events.zoom.us/ev/Ag1AUcW3n...

Are you interested in Master's studies with the groups of our LED3 hub? You can sign up for the Master's Online Open Day on October 15th and learn about the diverse programs across our institutes. For more information, visit: shorturl.at/rkDj0 #DrugDiscovery #ChemBio #Science #Master #MSc

Are you looking for Master's studies in Chemistry or Life Science & Technology? Make sure to check out the great opportunities at @leidenscience.bsky.social! If you want to learn more, you can sign up for our Master's Online Open Day on October 15th. For more information, visit: shorturl.at/rkDj0

How can we figure out, how protein activity is controlled in space and time? I am very happy that @janavolaric.bsky.social joined the @led3hub.bsky.social as an NWO VENI fellow this year to address exactly this question using exciting optical tools. (1/3) #ChemSky #ChemBio #Light #LipidTime #Lipids

Huge Congratulations to the three winners of our abstract challenge: Yutong Zhang @zyt0329.bsky.social Lars Stevens-Cullinane Wahyu Widodo @wahyuwidodo.bsky.social Register for the 6th Virtual ChemBioTalks to hear their talks: events.zoom.us/ev/Ag1AUcW3n... (1/2)

Congratulations to the three winners of the @chembiotalks.bsky.social abstract challenge! Join their Talks: events.zoom.us/ev/Ag1AUcW3n... Thank you also to all the many other participants for making our job of selecting the best abstracts very, very hard. #ChemBio #ChemSky #Award #Congratulations

Virtual ChemBioTalks@chembiotalks.bsky.social · last mo.

Huge Congratulations to the three winners of our abstract challenge: Yutong Zhang @zyt0329.bsky.social Lars Stevens-Cullinane Wahyu Widodo @wahyuwidodo.bsky.social Register for the 6th Virtual ChemBioTalks to hear their talks: events.zoom.us/ev/Ag1AUcW3n... (1/2)

Looking forward to another year of exciting @led3hub.bsky.social Lectures with nine world-leading scientists visiting us in Leiden and sharing their exciting stories about research in early drug discovery. #ChemSky #ChemBio #DrugDiscovery CC: @leidenscience.bsky.social

Leiden Early Drug Discovery & Development (LED3)@led3hub.bsky.social · last mo.

With the start of the new academic year, we are very happy that also the LED3 Lectures will start again shortly. Mark your calendars and let us know, which lectures you are looking forward to the most! www.universiteitleiden.nl/en/science/l... #ChemSky #ChemBio #DrugDiscovery #Science

With the start of the new academic year, we are very happy that also the LED3 Lectures will start again shortly. Mark your calendars and let us know, which lectures you are looking forward to the most! www.universiteitleiden.nl/en/science/l... #ChemSky #ChemBio #DrugDiscovery #Science

What can careers for scientists outside of academia look like? Cindy Gerhardt gave a great LED3 Career Inspiration Talk on this topic. We were happy to see an audience that engaged in a lot of interesting discussion with her. It was great to co-organize this event with @leidenscience.bsky.social.

How can more stable antibody-drug conjugates be synthesized and translated into the clinics? I am excited that we will host Christian Hackenberger for a @led3hub.bsky.social Lecture, in which he will discuss, how his group is answering this question. www.universiteitleiden.nl/en/science/l...

We are looking forward to the LED3 Lecture by Christian Hackenberger on September 24th: "P5-Labeling to generate electrophilic probes and highly efficacious antibody-conjugates". Make sure to come by! www.universiteitleiden.nl/en/science/l... #ChemBio #ChemSky #DrugDiscovery #ADCs

A great talk by @kimmb1.bsky.social at the #qBioLeiden kick-off meeting. She talked about "Chemical tools to study biological immune processes" and gave exciting insights into the power of chemical tools to study biology on the example of NETosis. www.nature.com/articles/s42... #ChemSky #ChemBio

Erik Danen kicks-off the inaugural meeting of #qBioLeiden with an exciting lecture about the use of quantitative microscopy for #DrugDevelopment in the context of fibrosis and tumor immunology. www.nature.com/articles/s42... #DrugDiscovery #Microscopy CC: @led3hub.bsky.social

Can we better understand complex biological systems in a quantitative fashion? This important question brings together many scientists from @leidenscience.bsky.social and the Leiden University Medical Center in the new network #qBioLeiden. (1/3) www.universiteitleiden.nl/quantitative...

I am, of course, also extremely happy that the work led by Patrick Zanon in our lab, was selected for this review (www.nature.com/articles/s41...). Actually, Patrick was highlighted a second time for work that he contributed to in his postdoc with Matthew Disney (doi.org/10.1021/jacs...). (10/13)

Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry

Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...

nature.com

What are the hot topics in Chemical Biology? If you want to learn about the exciting perspective of students of Johannes Morstein's (@morstein.bsky.social) Ch/Bi145 course at @caltech.edu, you can now do so in their ChemBioChem review. doi.org/10.1002/cbic... (1/13) @chemistryeurope.bsky.social

Chemical Biology 2025: Highlights From the Ch/Bi145 Course at Caltech

This student-authored review highlights notable advances in synthetically enabled chemical biology from 2025, spanning bioconjugation and bioorthogonal chemistry, visualization and sensing, precision...

doi.org

What is the effect of stereochemistry on protein binding? In their tour-de-force study, the groups of Herman Overkleeft, Hans Aerts and @martola.bsky.social of our @led3hub.bsky.social comprehensively evaluate this question on the example of 1-deoxynojirimycin. (1/2) pubs.acs.org/jmcmar/artic...

A 16 × 8 Focused Compound Library Comprising All Configurational Isomers of the Archetypal Iminosugar, 1-Deoxynojirimycin

Abstract. Deoxynojirimycin is the archetypal iminosugar, from which many structural and configurational isosteres have been derived and studied in past dec

pubs.acs.org

Another great year of @led3hub.bsky.social Lectures lies ahead of us. Already mark your calendars and make sure to come by!

Leiden Early Drug Discovery & Development (LED3)@led3hub.bsky.social · 2mo ago

Mark your calendars for the LED3 Lectures of the new academic year! We are expecting an excellent line-up of speakers. If you have already put them into your agenda, we had one change of date from October 29th to 28th. www.universiteitleiden.nl/en/science/l... #ChemSky #ChemBio #DrugDiscovery

Mark your calendars for the LED3 Lectures of the new academic year! We are expecting an excellent line-up of speakers. If you have already put them into your agenda, we had one change of date from October 29th to 28th. www.universiteitleiden.nl/en/science/l... #ChemSky #ChemBio #DrugDiscovery