A single-vesicle fluorescence microscopy platform to quantify phospholipid scrambling

Nature Structural & Molecular Biology, Published online: 15 June 2026; doi:10.1038/s41594-026-01821-8Veit et al. present a fluorescence microscopy platform to measure protein scramblase-mediated lipid flipflop across membranes by imaging single vesicles containing fluorescent lipid probes to quantify precise transport rates.

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Mitochondria directly interact with the nuclear pore complex - Nature

Mitochondria interact directly with the nuclear pore complex via VDAC1–RANBP2 binding to sustain nuclear ATP levels.

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Researchers pioneer method to rapidly design proteins

Their strategy revealed new details that open the door to designing proteins with powerful abilities that could ultimately benefit medicine and manufacturing.

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Technologies to measure and modulate protein subcellular localization

Nature Reviews Molecular Cell Biology, Published online: 19 March 2026; doi:10.1038/s41580-026-00957-1Subcellular localization is important for protein function. This Review discusses advances in spatial subcellular proteomics, assesses the strengths and weaknesses of technologies that measure and control protein localization, and considers their potential uses in cell biology and medicine.

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Rethinking Cancer Metabolism - Westlake x Science\/AAAS Joint Online Symposium #01 (2026)

Altered metabolism is a hallmark of cancer: malignant cells re-engineer nutrient acquisition and utilization to fuel unchecked growth and survival. Beyond functioning as a simple energy powerhouse, metabolic rewiring reshapes virtually every layer of cell regulation, from chromatin architecture a...

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Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine - Nature Chemical Biology

Mast cells are immune cells that release membraneless mast cell extracellular granules (MCEGs) in response to allergic inflammation and pathogen infection. MCEGs are found to be condensates formed thr...

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2026 Fellows | Alfred P. Sloan Foundation

Our mission is to make the world a better place through the advancement of scientific knowledge.

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Decoding the proton veil around lysosomes - Nature Cell Biology

A newly discovered acidic nanolayer that envelopes lysosomes reveals that proton gradients extend beyond the organelle lumen, identifying a nanoscale regulatory interface that links luminal pH, TMEM17...

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DNA nanodevices detect an acidic nanolayer on the lysosomal surface - Nature Cell Biology

Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in...

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DNA nanodevices detect an acidic nanolayer on the lysosomal surface - Nature Cell Biology

Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in...

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SPARK-seq: A high-throughput platform for aptamer discovery and kinetic profiling

Cell surface proteins are key disease biomarkers and therapeutic targets, yet high-throughput methods for aptamer discovery targeting these proteins in situ remain limited. We introduce single-cell pe...

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Molecular bioengineering of functional nucleic acids

Nature Reviews Bioengineering, Published online: 17 October 2025; doi:10.1038/s44222-025-00361-yFunctional nucleic acids (FNAs) achieve specific target recognition, molecular binding and catalytic activity by folding into defined secondary and tertiary structures. This Review focuses on two major classes of FNAs — aptamers and DNAzymes — and discusses their structural features, production strategies and engineering approaches as well as their clinical applications in diagnostics, targeted therapy and precision medicine.

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World’s most porous sponges: intricate carbon-trapping powders hit the market

Metal-organic frameworks were the next big thing in chemistry when they were invented more than three decades ago. Now, these intriguing materials are becoming commercial tools for capturing carbon dioxide and harvesting water from the air.

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These science prizes want to rival the Nobels: how do they compare?

Nature - Being named as a Nobel laureate is the ultimate prize for many scientists, but how do other science prizes compare?

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