Ayush Midha, a graduate student in the Jain Lab, is uncovering how the body adapts when oxygen runs low—work that has surprising ties to cancer and fertility.

Meet Gladstone: Ayush Midha

Ayush Midha, a graduate student in the Jain Lab, studies how the body's metabolism adapts to low oxygen—work that's uncovered backup energy pathways, potential fertility treatments, and a link between...

gladstone.org

Relatedly, new review! @cp-trendsbiochem.bsky.social It's often assumed that oxygen is required for eukaryotic metabolism, but early eukaryotes emerged when oxygen was scarce. Their descendants use a remarkable diversity of anaerobic electron acceptors. Read more here: www.cell.com/trends/bioch...

Ayush Midha@ayushmidha.bsky.social · last mo.

New preprint! www.biorxiv.org/content/10.6... We uncovered surprising roles for a little-known metabolic pathway, branched-chain amino acid fermentation, with implications for hypoxia, mitochondrial dysfunction, alcohol toxicity, and fertility.

New preprint! www.biorxiv.org/content/10.6... We uncovered surprising roles for a little-known metabolic pathway, branched-chain amino acid fermentation, with implications for hypoxia, mitochondrial dysfunction, alcohol toxicity, and fertility.

“These awardees stood out for their scientific originality, rigor and dedication to asking important scientific questions. They reflect the strength and promise of the next generation of scientific leaders.” - Dr. Bai, director of the Weintraub Award. www.fredhutch.org/en/news/rele...

I am excited to share our latest preprint showing that systemic hypoxia suppresses solid tumor growth: www.biorxiv.org/content/10.6... This has been a tremendous collaborative effort in the labs of Isha Jain @ishahjain.bsky.social and Hani Goodarzi @genophoria.bsky.social.

The latest from our group, led by Megan Ostrowski and @martyyang.bsky.social, is now published in final form (www.cell.com/cell/fulltex...! Many thanks to our excellent peer reviewers for suggesting several experiments (including CAF-1 perturbation) to really improve the study =) #epigenetics

The single-molecule accessibility landscape of newly replicated mammalian chromatin

By developing a long-read sequencing method to simultaneously map replication status and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated chromatin is enriched for unw...

cell.com