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Gladstone Institutes

@gladstoneinst.bsky.social

To drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and diverse environment.

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Gladstone Institutes@gladstoneinst.bsky.social · 4h ago

One last look at life as a PUMAS intern. Join Brenda Kurnia for a day in the Ramani Lab as this year's PUMAS cohort wraps up an unforgettable summer of research, mentorship, and discovery. Thanks to our 2026 interns for an incredible summer—we're cheering you on every step of the way.

A Day in the Life of a PUMAS Intern at Gladstone | Meet Brenda Kurnia

What does a day in the life of a PUMAS intern look like?Follow Brenda Kurnia as she takes you through a typical day at Gladstone Institutes, from her morning...

bit.ly

Gladstone Institutes@gladstoneinst.bsky.social · 4h ago

In a new study published in Science Translational Medicine, Gladstone scientists show that stem cell-derived spinal neurons can integrate into damaged neural networks in rats and improve breathing-related motor function after a traumatic spinal cord injury.

Engineered Human Neurons Rebuild Damaged Spinal Cord Circuits

Gladstone scientists show that stem cell-derived spinal neurons can integrate into damaged neural networks in rats and improve breathing-related motor function after a traumatic spinal cord injury.

gladstone.org

Gladstone Institutes@gladstoneinst.bsky.social · 5d ago

A new study shows that the TBX5 gene plays a role in physically folding DNA into the architecture that heart cells need to function—and losing one copy dismantles this DNA organization.

Findings From Second Phase of NIH 4D Nucleome Program Spelled Out in New Publications

A suite of new studies is revealing genome organization features and dynamics found in individual cells from a broad swath of tissue and cell types during health or disease.

genomeweb.com

Gladstone Institutes@gladstoneinst.bsky.social · 6d ago

Kazuo Nakamura joined Gladstone as a student intern in the lab of Seth Shipman, where he set out to search for retrons—bacterial defense mechanisms that scientists can harness for genome editing. What began as a teaching project quickly turned into real discovery. #NationalInternDay

From Hiking Trails to the Lab: Discovering New Retrons

Kazuo Nakamura joined Gladstone as a student intern in the lab of Seth Shipman, where he set out to search for retrons--bacterial defense mechanisms that scie...

bit.ly

GOA - Genome Organisation Australia@genome-org-aus.bsky.social · last wk.

Amazing work by GOA convener Dr Zoe Grant! Her study on the impact of the 3D genome in heart disease was just published in Science! Read about it here: www.science.org/doi/abs/10.1...

Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor

Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type–specific gene regulation is linked to the reorganization of three-dimensio...

science.org

Gladstone Institutes@gladstoneinst.bsky.social · last wk.

Congenital heart disease is the most common birth defect. In a new study published in @science.org researchers investigated why losing just one functional copy of the gene TBX5—a genetic cause of congenital heart disease—can have such devastating effects on heart development.

Gladstone Institutes@gladstoneinst.bsky.social · last wk.

The method to reprogram fully differentiated cells using transcription factors retools cells—and has retooled many a scientist's trajectory. In this piece, researchers comment on this ‘remodeling' and the future they foresee.

iPS cells: history made and history in the making - Nature Methods

The method to reprogram fully differentiated cells using transcription factors retools cells — and has retooled many a scientist’s trajectory. Here, researchers comment on this ‘remodeling’ and the future they foresee.

nature.com

Gladstone Institutes@gladstoneinst.bsky.social · last wk.

Alex Marson is co-leading a new effort to build a comprehensive atlas of T cell receptors involved in food allergies, laying the groundwork for more precise diagnostics and new therapies.

Food Antigen Atlas for New Regulatory T Cell Therapies in Food Allergy -- Food Allergy Fund

Building on its recent advances with the Chan Zuckerberg Biohub Billion Cells Project, “a project (which) will provide a necessary scale of data to understand the functional effects of human genetic variants and characterize the genetic drivers of human...

foodallergyfund.org

Gladstone Institutes@gladstoneinst.bsky.social · last wk.

🚨 NEW PUBLICATION 🚨 "Linkage disequilibrium and allelic heterogeneity explain variation in coronary artery disease risk at 9p21 across populations and reduced effect in Africans" in @ajhgnews.bsky.social

Linkage disequilibrium and allelic heterogeneity explain variation in coronary artery disease risk at 9p21 across populations and reduced effect in Africans

Using cross-ancestry fine-mapping across global and local ancestry groups, this study dissects the 9p21.3 coronary artery disease locus and shows how ancestry-specific haplotype structure shapes assoc...

cell.com

Gladstone Institutes@gladstoneinst.bsky.social · 2w ago

🚨NEW PUBLICATION🚨 Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor in @science.org @benoitbruneau.bsky.social @ucsfanesthesia.bsky.social @ucsanfrancisco.bsky.social

Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor

Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type–specific gene regulation is linked to the reorganization of three-dimensio...

science.org

Gladstone Institutes@gladstoneinst.bsky.social · 2w ago

For decades, a DNA-based test for cardiovascular disease seemed to work for Europeans and others but not Africans. Gladstone scientists just discovered why, with implications for many other diseases.

Heart Disease Genetic Risk: New Study Reveals Why Populations Differ

For decades, a DNA-based test for cardiovascular disease seemed to work for Europeans and others but not Africans. Gladstone scientists just discovered why, with implications for many other diseases.

gladstone.org

Gladstone Institutes@gladstoneinst.bsky.social · 2w ago

On #WorldBrainDay, we're celebrating discoveries that help us better understand the brain. Gladstone researchers developed a new way to map how the brain clears away waste. The study found this cleanup process is disrupted in inflammation and Alzheimer's, opening opportunities for future therapies.

Mapping How the Brain Takes Out Its Trash

Gladstone scientists developed a new tool to trace how the brain clears “waste,” uncovering surprising new biology about how it keeps itself healthy.

gladstone.org

Gladstone Institutes@gladstoneinst.bsky.social · 2w ago

What if AI could do more than analyze data—what if it could design and run scientific experiments? Join Gladstone's Steve Finkbeiner at @cwclub.bsky.social for a conversation about the AI-powered "thinking microscope" and how it's changing the future of biomedical research.

Giving Scientists Superpowers: How an AI-Powered “Thinking Microscope” Is Fast-Tracking Medical Breakthroughs

Gladstone’s Steven Finkbeiner shares how Gladstone’s AI-powered microscope is racing to cure neurodegenerative disease.

commonwealthclub.org