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Ingo Ott

@iottgroup.bsky.social

Group of Prof. Ingo Ott at Technische Universität Braunschweig, Bioinorganic Medicinal Chemistry, Metallodrugs, PI run account

19 Posts949 Follower680 Folgt
Ingo Ott@iottgroup.bsky.social · 3mo ago

Very happy about the opportunity to present our latest work on antiviral metallodrugs at this great conference! Many thanks to the organisers for the kind invitation and the perfect organization! I have greatly enjoyed the days full of exceptional bioinorganic chemistry research!

EuroBIC 18 Conference@eurobic18.bsky.social · 3mo ago

That’s a wrap on EuroBIC 18! 🎉 An unforgettable week of outstanding science and inspiring discussions in Groningen. Thank you to all speakers, participants, sponsors, exhibitors, helpers, and everyone who helped make EuroBIC 18 such a success. See you at EuroBIC 19 in Lisbon 🇵🇹 in 2 years!

Ingo Ott@iottgroup.bsky.social · 4mo ago

It was great to meet @thebabaklab.bsky.social and many other colleagues at the 3rd edition of the Symposium on Anticancer Metal Drugs in beautiful Palermo! Looking forward already to edition 4!

The Babak Lab@thebabaklab.bsky.social · 4mo ago

Warm welcome at the University of Palermo! 🇮🇹 Special thanks to all colleagues for making this symposium so inspiring and memorable. #AntiCancer #DrugSymposium #LabLife #CancerResearch #MetalBasedDrugs #UniversityOfPalermo

Ingo Ott@iottgroup.bsky.social · 8mo ago

Are you interested in recent developments on gold N-heterocyclic carbene complexes as antibacterial tool compounds and potential antibiotics? In this new review paper (open access) you will find what you always wanted to know about this topic: www.sciencedirect.com/science/arti...

Recent developments on gold N-heterocyclic carbene complexes as antibacterial tool compounds and potential antibiotics

Gold complexes with N-heterocyclic carbene (NHC) ligands have been intensively studied as new anticancer agents, while other biomedical and therapeuti…

sciencedirect.com

Jeannine Hess@jeanninehess.bsky.social · last yr.

🧪 Excited to share our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻 chemrxiv.org/engage/chemr...

Proteome-Wide Target Identification Using Reactive Metallo-Scaffolds (r-mS): A Platform for Metallodrug Discovery

Metal complexes offer unique opportunities as scaffolds in chemical biology and drug discovery, with tuneable geometry, modular coordination environments, and structural features not readily accessibl...

chemrxiv.org

Ingo Ott@iottgroup.bsky.social · last yr.

Our latest paper on antiviral metallodrugs is online (open access)! Great collaboration with the team of Luca Ronconi from Galway on gold compounds as protease inhibitors with strong antiviral activity! www.sciencedirect.com/science/arti...

Potent inhibition of SARS-CoV-2 proteases PLpro and 3CLpro by selected gold(III)-dithiocarbamato complexes showing strong and selective antiviral activity against HCoV-OC43

Selected gold(III)-dithiocarbamato complexes were identified as potent inhibitors of two critical enzymes involved in the SARS-CoV-2 replication cycle…

sciencedirect.com

Ingo Ott@iottgroup.bsky.social · last yr.

This week the foundation stone of our new pharmacy building at TU Braunschweig was laid! The new pharmacy campus will have a huge impact on research and teaching in medicinal chemistry and all aspects of drug research. Looking forward to it a lot! magazin.tu-braunschweig.de/en/pi-post/f...

Foundation stone laid for new pharmacy building - TU Braunschweig | Blogs

On 9 July, Technical University of Braunschweig celebrated another milestone in its renovation programme with the symbolic laying of the foundation stone

magazin.tu-braunschweig.de

Ingo Ott@iottgroup.bsky.social · last yr.

Happy to see our latest work on anticancer gold organometallics published! We report on a gold alkynyl complex with promising in-vitro and in-vivo activity (open access). Thanks to @gassergroup.bsky.social for the nice collaboration! pubs.rsc.org/en/content/a...

Antiproliferative effects, mechanism of action and tumor reduction studies in a lung cancer xenograft mouse model of an organometallic gold( i ) alkyn ... - RSC Medicinal Chemistry (RSC Publishing) D...

pubs.rsc.org

Ingo Ott@iottgroup.bsky.social · last yr.

"Silver N-Heterocyclic Biscarbene Complexes: Potent Inhibitors of Thioredoxin Reductase with Anticancer Activity in Vitro and in Vivo." Many thanks to @thebabaklab.bsky.social for the great collaboration! Open access: aces.onlinelibrary.wiley.com/doi/full/10....

Silver N‐Heterocyclic Biscarbene Complexes: Potent Inhibitors of Thioredoxin Reductase with Anticancer Activity in Vitro and in Vivo

Silver N-heterocyclic carbene complexes in the biscarbene form represent a promising type of TrxR-inhibiting organometallic anticancer drug candidates with activity in vitro and in vivo.

aces.onlinelibrary.wiley.com

Ingo Ott@iottgroup.bsky.social · 2y ago

Is silver the new gold? In this paper we report on silver NHC complexes and their antibacterial mechanism of action. pubs.rsc.org/en/content/a...

Modulation of the mechanism of action of antibacterial silver N-heterocyclic carbene complexes by variation of the halide ligand

The antimicrobial properties of silver and silver complexes have been known in medicine since ancient times. However, limitations in stability and solubility have impaired medicinal chemistry and drug...

pubs.rsc.org