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Karges Group

@kargesgroup.bsky.social

Full Professor in Biophysics at Faculty of Medicine, Ruhr University Bochum, Group Website: https://www.kargesgroup.ruhr-uni-bochum.de/

56 Posts1192 Follower1148 Folgt
Healthcare in Europe (DE)@health-europe-de.bsky.social · 4mo ago

Manche #Tumoren wachsen so schnell, dass das Gefäßwachstum nicht mithält und sich im Inneren sauerstoffarme Bereiche bilden. Forscher der @kargesgroup.bsky.social an der @ruhr-uni-bochum.de haben einen Wirkstoff entwickelt, der ihre Behandlung mit photodynamischer Therapie möglich machen soll.

Photodynamische Therapie eröffnet neue Behandlungsoptionen bei schnell wachsenden Tumoren

Die photodynamische Therapie gegen Krebs basiert darauf, Patienten eine zunächst inaktive Substanz zu verabreichen, die erst im Tumor durch gezielte Lichtbestrahlung aktiviert wird.

healthcare-in-europe.com

@joseruizlab.bsky.social · 6mo ago

Thrilled to share our latest collaboration with @kargesgroup.bsky.social! Huge congrats to @antoniolinero.bsky.social & all co-authors, including @nmontesdeocas.bsky.social. Exciting advances in photoactivated iridium nanomaterials & oncosis‑driven cancer cell death. doi.org/10.1021/acsa...

Encapsulation of a Cyclometalated Iridium(III) Photosensitizer into Nanosized Micelles for Oncosis-Inducing Photodynamic Therapy

The reliance of many anticancer agents on apoptosis often limits their therapeutic efficacy and contributes to the development of drug resistance. To overcome these challenges, alternative mechanisms ...

doi.org

Karges Group@kargesgroup.bsky.social · 6mo ago

Check out our perspective in J. Med. Chem. @acsmedi.bsky.social about the Limitations of DCFH-DA for the Detection of ROS and Recommendations for Probe Selection. @ruhr-uni-bochum.de dx.doi.org/10.1021/acs....

Reactive Oxygen Species Detection with Fluorescent Probes: Limitations and Recommendations beyond DCFH-DA

Reactive oxygen species (ROS) are highly reactive molecules derived from molecular oxygen that play critical roles in cellular signaling, homeostasis, and the regulation of various physiological and pathological processes. Accurate detection and quantification of ROS are essential for elucidating their roles in health and disease. Despite significant advances in ROS probe development, challenges persist due to their short lifetimes, high reactivity, and their chemical diversity. This perspective article provides a critical evaluation of the limitations of the most commonly applied probe molecule DCFH-DA. Capitalizing on this, recommendations with practical applications in the lab for the specific detection of hydrogen peroxide, hydroxyl radical, singlet oxygen, superoxide anion, and peroxynitrite are provided. By integrating current knowledge on ROS probe technologies, this work aims to guide researchers in reliably assessing ROS in complex biological systems, thereby facilitating a deeper understanding of ROS-mediated processes and their implications for disease research and therapeutic development.

dx.doi.org

Karges Group@kargesgroup.bsky.social · 8mo ago

Incredibly proud to congratulate @antoniolinero.bsky.social on defending his PhD! He did a fantastic job. It’s been an honor to accompany him on this journey and to share this achievement with @joseruizlab.bsky.social, @vanesafm-isqch.bsky.social, @giampaolobarone.bsky.social and Dolores Santana. 🎉

Vanesa Fernández-Moreira@vanesafm-isqch.bsky.social · 8mo ago

After an outstanding PhD defence by @antoniolinero.bsky.social. we’re enjoying the best of Murcia with @joseruizlab.bsky.social , @giampaolobarone.bsky.social and @kargesgroup.bsky.social! Proud moment.

Healthcare in Europe (DE)@health-europe-de.bsky.social · last yr.

👉 Ein von der @kargesgroup.bsky.social an der @ruhr-uni-bochum.de entwickelter neuer Wirkstoffkomplex tötet Krebszellen auf eine so geschickte Art, dass sie im Sterben dem #Immunsystem den Weg zu #Metastasen zeigt, die sich an entfernten Orten im Körper entwickeln.

Sterbende Tumorzellen machen Metastasen zur Zielscheibe

Ein neuer Wirkstoff kann Krebszellen beseitigen und gleichzeitig das Immunsystem trainieren, solche Zellen überall im Körper zu vernichten.

healthcare-in-europe.com