Our #Trypanosoma cruzi single-cell atlas paper is now available online! Great work by Ross Laidlaw and Marta Garcia Sanchez, and excellent collaboration with Thomas Otto! rdcu.be/flOWR @ddu-dundee.bsky.social, @dundeeuni.bsky.social #single-cell, #Chagas, #atlas, #trypanosome, #scRNA-seq 🧪🔬

World Chagas Disease Day acts as a reminder of a global health challenge that often goes unnoticed. In our latest blog, Manu De Rycker from the @dundee.ac.uk shares what his team are doing to combat this disease. #ChagasDisease www.sfc.ac.uk/inside-the-u...

Inside the University of Dundee’s long‑term fight against Chagas disease - Scottish Funding Council

World Chagas Disease Day acts as a reminder of a global health challenge that often goes unnoticed. Manu De Rycker shares what his team are doing to combat this disease.

sfc.ac.uk

Today is World #ChagasDisease Day. For too long, women have been stigmatized for a disease they didn't choose. Most were infected the same way as everyone else by insect transmission, contaminated food, or other routes. It's time to replace stigma with support. 🧡 Learn more 👉 bit.ly/4cIYv4I

Just as the world needs global health the most, we are losing 20th century visionaries. Foege, Hinman, and now Nick White. Sir Nick White transformed malaria treatment with data on artemisinin. Billions treated, millions saved Mentor to many @MORUBangkok @OUCRU_Vietnam @nuffieldcollege.bsky.social

Professor Sir Nicholas White OBE KCMG FRS

The University of Oxford and the Nuffield Department of Medicine greatly mourn the death of Professor Sir Nicholas White, a distinguished clinician and scientist who was internationally recognised as ...

ndm.ox.ac.uk

Hot off the press: our Target Product Profile to support the development of new medicines to treat #cryptococcal disease: www.sciencedirect.com/science/arti... #cryptococcus, #drugdiscovery, #meningitis @ddu-dundee.bsky.social, @gsk.bsky.social, @dndi.org and many others 🧪

Target product profile and discovery and development path for novel cryptococcal disease treatments

Cryptococcus neoformans and Cryptococcus gattii are World Health Organization critical and medium priority pathogens, respectively. These mainly impac…

sciencedirect.com

#Chagas disease remains very neglected, and not only in the US, in spite of an estimated 8 million people being infected with T. cruzi. We, and our collaborators, aim to develop new medicines, but this is becoming increasingly challenging due to lack of funding. www.theguardian.com/us-news/2025...

‘Kissing bug’ disease should be treated as endemic in US, scientists say

People in at least eight states have been infected with Chagas, new report says, amid low awareness of disease

theguardian.com

Great opportunity to join our multi-partner collaboration to develop much needed new #antifungal drugs! #jobs, #drugdiscovery, #Cryptococcus, #Candida @mrccmm.bsky.social @ddu-dundee.bsky.social @labwyllie.bsky.social @glaxosmithkline.bsky.social

The MRC Centre for Medical Mycology@mrccmm.bsky.social · 11mo ago

🚨 Join the MRC CMM 🚨 Assay Development Scientist 1: buff.ly/0RfOxPP Assay Development Scientist 2: buff.ly/qEgHd7Z Postdoc Research Associate Drug Discovery: buff.ly/8u2TV1S Technician Assay Development & Drug Discovery: buff.ly/CITpQ69

Delighted to announce a £17.9 million award from @wellcometrust.bsky.social for the development of new antifungal treatments to a consortium of @ddu-dundee.bsky.social, @labwyllie.bsky.social, @mrccmm.bsky.social and GSK. #Cryptococcus #Candida #drugdiscovery #antifungal 🧪 tinyurl.com/wywtkpsx

£17.9m research grant to discover new treatments for fungal diseases

A team of leading infectious disease scientists from academia and industry have been awarded £17.9 million to identify new drugs to treat fungal infections

tinyurl.com

Great to have a latest #Chagas disease drug discovery paper published in @rsc.org MedChem: pubs.rsc.org/en/content/a... This work highlights how we decide to progress or terminate series, and hopefully provides some useful approaches and lessons. @ddu-dundee.bsky.social 🧪 #NTD #drugdiscovery

Structure–activity relationships of 1,5-dihydro-2H-benzo[b][1,4]diazepine-2,4(3H)-diones as inhibitors of Trypanosoma cruzi

Chagas disease, caused by infection with the protozoan parasite Trypanosoma cruzi (T. cruzi), is responsible for a large health burden with around 6–8 million people infected globally. The current dru...

pubs.rsc.org

Please repost: We have a postdoc position in Antifungal Immunity Research available to study T cell responses and fungal sensitization in atopic dermatitis. @lableibundgut.bsky.social @neil-gow.bsky.social @mrccmm.bsky.social For more details, visit: jobs.exeter.ac.uk/hrpr_webrecr...

Please repost: We have a postdoc position in Fungal Cell Wall Research available to study the Malassezia-host interaction interface in the context of atopic dermatitis. @lableibundgut.bsky.social @neil-gow.bsky.social @mrccmm.bsky.social For more details, visit: jobs.exeter.ac.uk/hrpr_webrecr...

We're proud to share our new short film shot in Colombia’s #SierraNevada where the Indigenous Wiwa people live with some of the highest rates of #Chagas disease in the world. www.youtube.com/watch?v=VIo7...

The Children of the Sierra

YouTube video by Drugs for Neglected Diseases initiative (DNDi)

youtube.com

Yesterday, over 200 guests joined us at Swiss TPH to celebrate the legacy in of our former Director, Marcel Tanner, at the launch of his biography. As #GlobalHealth funding declines & partnerships face pressure, the event served as a reminder to work together to ensure continued progress in health.

A Life for Global Health: Book Launch Celebrates Marcel Tanner’s Legacy

Over 200 guests gathered at the Swiss Tropical and Public Health Institute (Swiss TPH) in Allschwil today to celebrate the launch of Marcel Tanner’s biography. The festive event...

swisstph.ch

My colleague @mgerver.bsky.social has created this open letter to Keir Starmer opposing the measures announced in last week's Immigration White Paper, on economic, political and moral grounds. Open to all academics/researchers to sign. molliegerver.weebly.com/petition.html

Petition

An Open Letter to Keir Starmer We, the undersigned, strongly advise against the proposed changes to the UK immigration system of May 12, 2025, and your associated rhetoric. We are UK-based academics.....

molliegerver.weebly.com

Happy to announce that today we start a new #Chagas drug discovery project, funded by MRC @ukri.org. In this project we will be carrying out lead optimisation on a series of squalene synthase inhibitors. More info at: gtr.ukri.org/projects?ref... 🧪 @ddu-dundee.bsky.social #UniversityOfDundee

Early reports to WHO from the 30 highest #tuberculosis (TB)-burden countries confirm that funding cuts from foreign aid, particularly from USAID, are already dismantling essential TB services. Without urgent action, these setbacks will reverse decades of progress to #EndTB 🔗 bit.ly/4kvsu2i

Great opportunity to come and be part of our #tuberculosis drug discovery team. This position will be responsible for integrating data from our #TB collaborators with our internal results (medchem, structural biology and pharmacokinetics). #drugdiscovery, #jobs, #science 🧪

Drug Discovery Unit, University of Dundee@ddu-dundee.bsky.social · last yr.

Come work with us! An opportunity is available within our #TB portfolio as a #DrugDiscovery #Biology coordinator. See the attached link for further details and for contact information for informal enquiries. #BiologyJobs www.dundee.ac.uk/work-for-us/...

Opening for a post-doctoral position in Michael Lewis’ lab at @uni-of-warwick.bsky.social. Great opportunity for those interested in working on Trypanosoma cruzi biology and #Chagas pathogenesis! 🧪 #jobs, #NTD, #Trypanosoma www.jobs.ac.uk/job/DMA372/r...

Research Fellow (110168-0225) at University of Warwick

An academic position as a Research Fellow (110168-0225) is being advertised on jobs.ac.uk. Click now to find more details and explore additional academic job opportunities.

jobs.ac.uk

🎉 This #WorldNTDDay we celebrate Guinea for successfully eliminating sleeping sickness! 👏 📽️ Watch our movie, created in collaboration with the Ministry of Health, @ird-fr.bsky.social and Institut Pasteur de Guinée produced by Moronga Films. bit.ly/guineafilm-en #EndTheNeglect #BeatNTDs

Bölët Mouna | Ending Sleeping Sickness in Guinea

Bölët Mouna means ‘sleeping sickness no more’ in Guinea’s national language Susu and tells the story of how research, innovation, and science are ending the the nightmare of sleeping sickness in Guinea. In January 2025 Guinea announced that it had eliminated sleeping sickness as a public health problem. This is the first disease that the country can claim to have eliminated and a major milestone in the Africa-wide campaign to eliminate sleeping sickness. The National Sleeping Sickness Programme in Guinea and its international partners – among them the French National Research Institute for Sustainable Development (IRD), the Drugs for Neglected Diseases initiative (DNDi), and the Institute Pasteur – have used all the tools at their disposal to achieve this milestone: small ‘tiny traps’ that dot the mangrove coasts of Guinea, rapid diagnostic tests, and revolutionary new medicines that are changing how doctors treat their patients. Read more about this achievement: https://stories.dndi.org/boletmouna/ Regarder en français: https://youtu.be/0S-ZSNcQEvY The Drugs for Neglected Diseases initiative (DNDi) is an international non-profit developing safe, effective, and affordable treatments for the most neglected patients. https://dndi.org

bit.ly

🧵 STATEMENT: WHO expresses deep concern on the implications of the immediate funding pause for #HIV programmes in low- and middle-income countries. These programmes provide access to life-saving HIV therapy to more than 30 million people worldwide. Read more bit.ly/42yxxIz 1/5

Opportunity for #DrugDiscovery data scientist at DNDi (Rio de Janeiro Brazil) ref: 2025-1199 #DataScience #cheminformatics #NTD #infection #Chagas #leishmaniasis #HepC #dengue 🧪 careers-dndi.icims.com/jobs/1199/di...

Working at DNDi | DNDi

At DNDi, our work begins with our people: we aim to recruit people who both reflect and understand the diversity of needs and experiences of those we serve.

careers-dndi.icims.com

New version of our #Trypanosoma cruzi pre-print is now online. Includes new analysis on UTR complexity and reveals cell-specific repertoires for surface protein families, which may play an important role in the immune evasion strategy of this pathogen. www.biorxiv.org/content/10.1...

The Trypanosoma cruzi cell atlas; a single-cell resource for understanding parasite population heterogeneity and differentiation.

Trypanosoma cruzi, the causative agent of Chagas disease, exhibits a complex life cycle with multiple hosts, stages and differentiation steps. We present a complete cell atlas for the T. cruzi life cy...

biorxiv.org

Great to see the final version of our latest paper now published! We recombinantly produced the #Trypanosoma cruzi #proteasome, determined its cryo-EM structure, revealed substrate promiscuity and generated multiple mutants for better pharmacological understanding. www.jbc.org/article/S002... 🧪

Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors

The proteasome is considered an excellent drug target for many infectious diseases as well as cancer. Challenges with robust and safe supply of proteasomes from infectious agents, lack of structural information, and complex pharmacology due to multiple active sites have hampered progress in the infectious disease space. We recombinantly expressed the proteasome of the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease, and demonstrate pharmacological equivalence to the native T. cruzi proteasome.

jbc.org

For anybody with an interest in cryptococcal meningitis. #cryptococcus #meningitis #fungal 🧪

Dr. D Boulware, MD MPH@drboulware.bsky.social · 2y ago

Great upcoming Columbia ICAP Grand rounds on #Crypto in LMIC settings by two great women in medicine of Radha Rajasingham and Kiran Thakur. January 21, 9am US EST If you are a #Crypto millionaire and want to help millions with crypto disease, come listen. icap.columbia.edu/news-events/...

Science’s 2024 Breakthrough of the Year is lenacapavir, an injectable drug that demonstrated remarkable success at preventing HIV infection with one shot every 6 months. Learn more about this year's #BOTY and other big advances in science: scim.ag/3BrCtUn

Excellent science teaching resource, building on the fascinating story of the discovery of #Trypanosoma cruzi and its vector by Carlos #Chagas.

Nathália Helena Azevedo@nhazevedo.bsky.social · 2y ago

Happy to share this work doi.org/10.1525/abt.... which delves into Chagas’ remarkable research. This piece aims to contribute to the teaching of the #historyOfScience and raise awareness about #neglectedDiseases like #Chagas, which still affects over 6 million people globally #BiologyEducation

🚨 Multiple #parasite -based PhD opportunities from the EastBio Doctoral Training Programme at Edinburgh Uni! 🚨 - Deadline for all are the 17th Jan '25 1. Trypanosoma co-infections: tinyurl.com/vyv855kw 2. Mitochondrial genome complexity in #trypanosoma: tinyurl.com/c6hk652f #Parasitology #ntds

EastBio: Keeping up with the Joneses: how do trypanosome parasites adapt to coinfection with other trypanosomes? at University of Edinburgh on FindAPhD.com

PhD Project - EastBio: Keeping up with the Joneses: how do trypanosome parasites adapt to coinfection with other trypanosomes? at University of Edinburgh, listed on FindAPhD.com

tinyurl.com

🚨 Save the Date - BSP Specialist #Kinetoplastid meeting in Czechia! 🚨 - 𝟭-𝟰𝘁𝗵 𝗦𝗲𝗽𝘁, 𝟮𝟬𝟮𝟱 - #Trypanosoma & #Leishmania biology and epidemiology - More details to come at tinyurl.com/mpr88zed - Followed by a mini-symposium to celebrate Prof Alan Fairlamb's achievements in the field! #parasitology

The University of Dundee Drug Discovery Unit is now on Bluesky, find us @ddu-dundee.bsky.social! We are over 100 scientists focused on developing new treatments for tropical infectious diseases, new approaches for #drugdiscovery and proof of concept for novel targets. 🧪 drugdiscovery.dundee.ac.uk

Delighted that our work on the Trypanosoma cruzi #proteasome is now accepted by The Journal Of Biological Chemistry and available online!🧪 www.jbc.org/article/S002...

Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors

The proteasome is considered an excellent drug target for many infectious diseases as well as cancer. Challenges with robust and safe supply of proteasomes from infectious agents, lack of structural i...

jbc.org