Every protein designer knows that producing & testing designed proteins is a foundational capability for our field, & this is still pretty challenging for a lot of folks. This is why I'm delighted to share our work to make high-throughput protein production more accessible dx.doi.org/10.1002/pro....

Facile, high‐throughput protein purification enabled by high‐efficiency protease elution

While advances in artificial intelligence have made protein design widely accessible, protein production and characterization remain a bottleneck. Protease-cleavable affinity tags are commonly used t....

dx.doi.org

We can design "static" binders routinely now, but design of "dynamic" shape-changing proteins has remained quite hard. Jeffrey Chang and I asked: why can't we couple small-molecule binding to shape change? After all, natural proteins do it every day. In a new preprint, we show how it can be done. 🧵

Three weeks ago, we welcomed the local scientific community to join us at our headquarters in Kenmore Square for the inaugural lecture in the AI Proteins Seminar Series. Our speaker Neil King from @uwproteindesign.bsky.social delivered a superb seminar. Check it out 👇 youtu.be/OPRMfRnlx1k

Neil King: ML-based design of nanoparticle vaccines (AI Proteins Seminar Series)

YouTube video by AI Proteins

youtu.be

⏰ Tomorrow! Join our webinar, Introduction to Protein Design for Africa, featuring speakers from AI Proteins, STEAMulater, Minimal Bio, and Nostrum Biodiscovery. Learn how protein design is advancing innovation and accessibility around the world! Register: us06web.zoom.us/webinar/regi...

Thank you to everyone who attended the inaugural lecture in the AI Proteins Seminar Series today. Neil King @kinglabipd.bsky.social gave a fantastic talk to a packed house!

We're delighted to kick off our new seminar series, and the inaugural speaker is none other than Neil King from the Institute for Protein Design, University of Washington "ML-based design of nanoparticle vaccines" June 3rd, 2026 12:00 PM – 1:00 PM EDT

Really fun and challenging (!) discussion with @cdbahl.com on BindCraft, the state of binder design, the oustanding challenges and perhaps also some misconceptions in the field 💫 www.healthtech.com/the-chain/ma...

Episode 84 Martin Pacesa on BindCraft An Automated Pipeline for De Novo Protein Binder Design

April 14, 2026 | How is BindCraft, the automated pipeline for de novo protein binder design, changing the protein design industry? Martin Pacesa, assistant professor of pharmacology at the University ...

healthtech.com

I never imagined this would happen ~8+ years ago. Just, wow. I'm so grateful to everyone in this community and for all the support and help from the many people that made it possible.

Boston Protein Design and Modeling Club@bpdmc.org · 4mo ago

We just passed an exciting milestone: our one thousandth member just joined @bpdmc.org! Thank you so much to everyone who has made this journey possible, and we're excited to welcome many more wonderful folks to our nerdy protein club! For more info, check out bpdmc.org

We've got two more positions open for RAs to join AI Proteins! One opening is for our Protein Characterization group led by Alyssa Anderson, and the other is for our Biochemistry group led by Edson Carcamo. These wet lab roles are a perfect for college students who are graduating this spring.

AI Proteins@aiproteins.com · 4mo ago

Our team is growing! We’re hiring for two new roles on our Biochemistry and Protein Characterization teams. These are hands-on, wet lab positions ideal for early-career scientists eager to make an impact and contribute to cutting-edge drug design. www.aiproteins.com/careers

We're recruiting a Research Associate to join our Bioprocess Development team. This is a wet lab role ideally suited for someone graduating college this spring who is excited to join a team pioneering a new therapeutic modality Check it out! 👇 www.aiproteins.com/open-positio...

I had a great time nerding out about protein design with @nickpolizzi.bsky.social, and an enormous thanks to @biotechtv.bsky.social and @massbio.bsky.social for hosting us! www.biotechtv.com/post/chris-b...

AI Proteins Founder & CEO Chris Bahl and Dana-Farber Cancer Institute Investigator Nick Polizzi discuss the current state of protein design and new innovations that are around the corner

Both experts in the field, one with an academic view and one from industry, they discuss what can be done today with protein design, new innovations coming in the next year or two, and how they think ...

biotechtv.com

Speaking as someone who had a career in academia before industry - there are many things I love about academia, but my job satisfaction is higher in industry. I hope things get better for all my friends in academia, because switching isn't the solution for everyone. www.nature.com/articles/d41...

Industry scores higher than academia for job satisfaction

Nature’s salary survey finds that industry researchers are more positive about their careers. Academia must raise its game.

nature.com

We've got Jeff Gray (graylab.jhu.edu) coming to present this month!! Wednesday, February 25th 2026, starting at 7pm EST in Room 181, Building 68, @MIT "Antibody language models vs. biology; protein docking denoising diffusion models vs. physics" bpdmc.org

schedule

introduction and membership Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in Boston...

bpdmc.org

Thanks for the fun conversation Ingmar Schuster, and for the opportunity to share more about what we're building at @aiproteins.com! youtu.be/7O0s5AY46U0

Chris Bahl on the Conundrum of Biotech Platforms

YouTube video by Provolut

youtu.be

I appreciate all the congratulations for our Series A! I also want to make sure we don't forget an important truth Funding is not the finish line. We're grateful for the resources we have, and my promise is that we'll continue to do everything in our power to make a difference

AI Proteins@aiproteins.com · 9mo ago

AI Proteins has closed a $41.5 million Series A financing to accelerate the development of de novo #miniproteins! The round was led by Mission BioCapital and SANTÉ, with robust participation from existing investors. See the official press release for details: www.businesswire.com/news/home/20...

The next chapter for AI Proteins @aiproteins.com is officially underway! I'm absolutely delighted to share that we’ve closed a $41.5M Series A led by Mission BioCapital and Santé Ventures. endpoints.news/boston-biote...

Exclusive: AI Proteins raises $42M Series A, and will launch miniproteins into hub-and-spoke model

AI Proteins raises $42M Series A for minibinder drug development, led by Mission BioCapital & Santé Ventures. CEO Chris Bahl aims to target TNFR1 with first candidate.

endpoints.news

My new @ted.com talk from the main stage just went live! go.ted.com/chrisbahl 🧵👇

The secret language of cells — and how to "speak" it

What if medicines could "speak" directly to your cells? Protein designer and TED Fellow Chris Bahl introduces a new generation of miniproteins: AI-designed medicines that can deliver detailed instruct...

go.ted.com

Join us in Room 181, Building 68 @mit.edu on October 22nd 2025 @ 7pm EDT to see @grocklin.bsky.social present a mind blowing amount of data and learn what becomes possible at this scale "Predicting protein folding stability and aggregation propensity using large-scale experiments" bpdmc.org

schedule

introduction and membership Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in Boston...

bpdmc.org

We're looking for a mass spec expert to join our team at @aiproteins.com! This position is ideal for a freshly-minted PhD grad (or someone who will graduate within the next 6 months or less), or a rockstar scientist who earned their skills on the job in biotech

AI Proteins@aiproteins.com · 11mo ago

We're #hiring a Scientist in Mass Spectrometry! Apply today or share this post with your network: www.linkedin.com/jobs/view/42... (ignore what linkedin says - the search is still open) Interested? Please email your CV to: careers@aiproteins.bio

🎥 Neste videocast produzido junto do @ieausp.bsky.social, tive uma conversa inspiradora com o Anderson Soares (UFG), @alexandre-cf.bsky.social e o @cdbahl.com sobre como a IA está moldando o futuro da biologia e da saúde humana. Assista aqui 👉 www.youtube.com/watch?v=qQbZ...

Inteligência Artificial Aplicada às Ciências da Vida

YouTube video by Instituto de Estudos Avançados da USP

youtube.com

Congratulations to Dr. James Bowman on his promotion to Chief Technology Officer! www.businesswire.com/news/home/20...

I am overjoyed to announce that James Bowman has been promoted to Chief Technology Officer at @aiproteins.com! 🧵👇

This was a lot of fun - thanks so much @yossefbaidi.bsky.social and @fang-xie.bsky.social ‪for the great conversation, and for your passion and excitement for biotech and entrepreneurship!

Yossef Baidi@yossefbaidi.bsky.social · last yr.

During this episode, @fang-xie.bsky.social and I interview @cdbahl.com, co-founder and CEO of @aiproteins.com. We discuss with Chris his interest in protein science and how he started his academic lab at the @ipiproteins.bsky.social.

Super excited to share a new preprint from our lab on design of small-molecule binding proteins using neural networks! The paper has a bit of everything. A new graph neural network, new design algorithms, and experimental validation. www.biorxiv.org/content/10.1... 🧵🧪

Zero-shot design of drug-binding proteins via neural selection-expansion

Computational design of molecular recognition remains challenging despite advances in deep learning. The design of proteins that bind to small molecules has been particularly difficult because it requ...

biorxiv.org

#IPISeminar alert 🔔 Friday at 2 p.m. ET, Chris Bahl of AI Proteins will share the challenges of incorporating #artificialintelligence into #proteindesign & the impact reimagined #miniproteins can have on therapeutics. Join us through the QR code or follow the Zoom link on our calendar! rb.gy/xcee9l

It was an honor to speak from the main stage at TED last week about our work at AI Proteins Our mission is to design the next generation of therapeutics built from de novo #miniproteins, and this was an unbelievable opportunity to help shape the broader conversation about the future of biologics

Big news to share! Phil Brandish has joined our team and will lead drug development efforts at AI Proteins. Phil is a rockstar, with a stellar track record and years of experience successfully bringing molecules into the clinic at Merck and Bicycle Therapeutics.

AI Proteins@aiproteins.com · last yr.

Welcome Phil Brandish, Chief Development Officer, to the AI Proteins team! www.businesswire.com/news/home/20...

I’m excited to share that I am now the CEO of AI Proteins @aiproteins.bsky.social! I’m grateful to continue leading this exceptional team as we build upon the strong foundation that we’ve established since launching the company in 2021. www.businesswire.com/news/home/20... 🧵👇

AI Proteins Appoints Founder Dr. Chris Bahl as Chief Executive Officer; Company to Present at Biotech Showcase 2025 during J.P. Morgan Healthcare Week

AI Proteins, Inc., a pioneering company utilizing artificial intelligence to design novel protein therapeutics, announces the appointment of its found

businesswire.com

So, I might have ended up on the jumbotron at the Celtics game proudly wearing my @aiproteins.bsky.social colors

Mireia Solà Colom gave an incredible seminar at @bpdmc.bsky.social last week, and I'm very excited for her to share some details about what we've built at @aiproteins.bsky.social and how well our #miniproteins perform as therapeutics

Boston Protein Design and Modeling Club@bpdmc.org · 2y ago

for the folks who weren't able to join for the brilliant presentation by Mireia Solà Colom last week to cap off our 2024 seminar series, you can check out the recording 👇 youtu.be/e6oZgGWjD_0