🧬 Want to stay updated on protein science? Check out the @bpdmc.org monthly presentation series! Recent topics: • Computational antibody design • Energy-based models & structure • De novo small-molecule induced changes Learn more, watch past presentations, and join the community at bpdmc.org.

If you weren't able to make it out for Jeffrey Chang's marvelous seminar this week, you can check out the recording 👇 youtu.be/q3Xn2-TIZEo

De novo design of small-molecule-induced conformational change

YouTube video by Boston Protein Design and Modeling Club

youtu.be

Quick reminder to join us tonight at DCFI for a super exciting talk by Jeffrey Chang!

Boston Protein Design and Modeling Club@bpdmc.org · 2w ago

Next week, Jeffrey Chang from @nickpolizzi.bsky.social's lab will present cutting-edge work from a pre-print that just came out today! Wednesday, August 12th 2026, 7pm EDT in Room 6055, Longwood Center, @danafarber.bsky.social "De novo design of small-molecule-induced conformational change"

Happening tonight! Come join in person or on zoom to hear Jeffrey talk about his work. Questions from zoom audience encouraged! www.bpdmc.org/schedule

schedule

introduction and membership Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in Boston...

bpdmc.org

The data, code, and detailed protocols are all available on github github.com/aiproteins/h... and all the plasmids are available on addgene www.addgene.org/233685/ www.addgene.org/233686/ www.addgene.org/kits/bahl-su...

GitHub - aiproteins/high_throughput_protein_production

Contribute to aiproteins/high_throughput_protein_production development by creating an account on GitHub.

github.com

Every protein designer knows that producing & testing designed proteins is a foundational capability for our field, & this is still pretty challenging for a lot of folks. This is why I'm delighted to share our work to make high-throughput protein production more accessible dx.doi.org/10.1002/pro....

Facile, high‐throughput protein purification enabled by high‐efficiency protease elution

While advances in artificial intelligence have made protein design widely accessible, protein production and characterization remain a bottleneck. Protease-cleavable affinity tags are commonly used t....

dx.doi.org

We can design "static" binders routinely now, but design of "dynamic" shape-changing proteins has remained quite hard. Jeffrey Chang and I asked: why can't we couple small-molecule binding to shape change? After all, natural proteins do it every day. In a new preprint, we show how it can be done. 🧵

Next week, Jeffrey Chang from @nickpolizzi.bsky.social's lab will present cutting-edge work from a pre-print that just came out today! Wednesday, August 12th 2026, 7pm EDT in Room 6055, Longwood Center, @danafarber.bsky.social "De novo design of small-molecule-induced conformational change"

De novo design of small-molecule-induced conformational change

Many biological proteins function by changing shape upon small-molecule binding. Here, we present a general strategy for designing de novo proteins that undergo small-molecule-induced conformational c...

biorxiv.org

If you missed James Roney's stellar talk last night, have no fear because you can check out the recording  👇 youtu.be/oZZumtlUXag

Energy-Based Models of Protein Structure, Dynamics, and Folding

YouTube video by Boston Protein Design and Modeling Club

youtu.be

quick reminder to join us at @mit.edu tonight for an awesome talk by James Roney from @sokrypton.org's lab!

Boston Protein Design and Modeling Club@bpdmc.org · last mo.

I hope everyone had a great 4th of July, and we've got a great seminar for you this week by James Roney from @sokrypton.org's lab! Join us this Wednesday, July 8th 2026 at 7pm EDT in Room 181, Building 68, @mit.edu "Energy-Based Models of Protein Structure, Dynamics, and Folding" bpdmc.org

I hope everyone had a great 4th of July, and we've got a great seminar for you this week by James Roney from @sokrypton.org's lab! Join us this Wednesday, July 8th 2026 at 7pm EDT in Room 181, Building 68, @mit.edu "Energy-Based Models of Protein Structure, Dynamics, and Folding" bpdmc.org

schedule

introduction and membership Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in Boston...

bpdmc.org

If you weren't able to make it out to MIT last month for Foster Birnbaum's outstanding seminar, you can now check out the recording 👇 youtu.be/w-NddBw2FJk

Beyond sequence recovery: Improved modeling of the sequence-energy landscape of protein structures

YouTube video by Boston Protein Design and Modeling Club

youtu.be

Three weeks ago, we welcomed the local scientific community to join us at our headquarters in Kenmore Square for the inaugural lecture in the AI Proteins Seminar Series. Our speaker Neil King from @uwproteindesign.bsky.social delivered a superb seminar. Check it out 👇 youtu.be/OPRMfRnlx1k

Neil King: ML-based design of nanoparticle vaccines (AI Proteins Seminar Series)

YouTube video by AI Proteins

youtu.be

quick reminder to head over to @mit.edu tonight for a great seminar!

Boston Protein Design and Modeling Club@bpdmc.org · 2mo ago

We've got an outstanding seminar for you this Wednesday, June 10th 2026 at 7pm EDT in Room 181, Building 68, @mit.edu Foster Birnbaum from @keatinglab.bsky.social "Beyond native sequence recovery: Improved modeling of the sequence-energy landscape of protein structures" bpdmc.org

We've got an outstanding seminar for you this Wednesday, June 10th 2026 at 7pm EDT in Room 181, Building 68, @mit.edu Foster Birnbaum from @keatinglab.bsky.social "Beyond native sequence recovery: Improved modeling of the sequence-energy landscape of protein structures" bpdmc.org

schedule

introduction and membership Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in Boston...

bpdmc.org

⏰ Tomorrow! Join our webinar, Introduction to Protein Design for Africa, featuring speakers from AI Proteins, STEAMulater, Minimal Bio, and Nostrum Biodiscovery. Learn how protein design is advancing innovation and accessibility around the world! Register: us06web.zoom.us/webinar/regi...

Thank you to everyone who attended the inaugural lecture in the AI Proteins Seminar Series today. Neil King @kinglabipd.bsky.social gave a fantastic talk to a packed house!

We're delighted to kick off our new seminar series, and the inaugural speaker is none other than Neil King from the Institute for Protein Design, University of Washington "ML-based design of nanoparticle vaccines" June 3rd, 2026 12:00 PM – 1:00 PM EDT

Ariel Tennenhouse gave a stellar talk this week! Don't fret if you weren't in the room last Wednesday night because you can check out the recording 👇 youtu.be/cQu6yUZINgo

We managed to line up another fantastic speaker from out of town this month thanks to #PEGSBoston! Come see Ariel Tennenhouse present on Wednesday, May 13th 2026 at 7pm EDT in Room 181, Building 68, @mit.edu "Computational design of antibody repertoires" bpdmc.org

schedule

introduction and membership Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in Boston...

bpdmc.org

Prof. Frank Noé is a leading figure at the intersection of machine learning and molecular science, with pioneering contributions that are reshaping our field. Hear his perspective at European RosettaCon 2026. Early bird registration closes May 31. europeanrosettacon.org

Really fun and challenging (!) discussion with @cdbahl.com on BindCraft, the state of binder design, the oustanding challenges and perhaps also some misconceptions in the field 💫 www.healthtech.com/the-chain/ma...

Episode 84 Martin Pacesa on BindCraft An Automated Pipeline for De Novo Protein Binder Design

April 14, 2026 | How is BindCraft, the automated pipeline for de novo protein binder design, changing the protein design industry? Martin Pacesa, assistant professor of pharmacology at the University ...

healthtech.com

If you missed Isaac Lutz's awesome seminar this week where he showcased state-of-the-art protein design starting from the days of physics-based energy functions all the way to modern agentic workflows, then you'll definitely want to check out the recording 👇 youtu.be/rSfSWc9wdDg

Creativity at Scale: Problem Formulation as the Frontier of Protein Design

YouTube video by Boston Protein Design and Modeling Club

youtu.be

We just passed an exciting milestone: our one thousandth member just joined @bpdmc.org! Thank you so much to everyone who has made this journey possible, and we're excited to welcome many more wonderful folks to our nerdy protein club! For more info, check out bpdmc.org

Quick reminder to join us at @danafarber.bsky.social tonight for a great talk by Isaac Lutz!

Boston Protein Design and Modeling Club@bpdmc.org · 5mo ago

No joke, we've got an exciting seminar this month from Isaac Lutz Wednesday, April 8th 2026 at 7pm EDT in Room 6055, Longwood Center, @danafarber.bsky.social "Creativity at Scale: Problem Formulation as the Frontier of Protein Design" bpdmc.org

No joke, we've got an exciting seminar this month from Isaac Lutz Wednesday, April 8th 2026 at 7pm EDT in Room 6055, Longwood Center, @danafarber.bsky.social "Creativity at Scale: Problem Formulation as the Frontier of Protein Design" bpdmc.org

schedule

introduction and membership Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in Boston...

bpdmc.org

Today is the last day to register for Summer RosettaCon 2026 at the early bird rate. We hope you’ll join us in Seattle, WA as we gather and discuss this year’s theme, “Biomolecule Engineering: From Principle to Practice.” Register today! rosettacon.org

We've got two more positions open for RAs to join AI Proteins! One opening is for our Protein Characterization group led by Alyssa Anderson, and the other is for our Biochemistry group led by Edson Carcamo. These wet lab roles are a perfect for college students who are graduating this spring.

AI Proteins@aiproteins.com · 5mo ago

Our team is growing! We’re hiring for two new roles on our Biochemistry and Protein Characterization teams. These are hands-on, wet lab positions ideal for early-career scientists eager to make an impact and contribute to cutting-edge drug design. www.aiproteins.com/careers

Quick reminder to join us at @danafarber.bsky.social tonight for an awesome talk by Jody Mou!

Boston Protein Design and Modeling Club@bpdmc.org · 6mo ago

Spring is arriving in Boston and Jody Mou linkedin.com/in/jody-mou has some fresh new data to share! Wednesday, March 11th 2026, 7pm EDT in Room 6055, Longwood Center @danafarber.bsky.social "Computational Design of a Rapid and Orthogonal Self-Labeling Protein Tag for Live-Cell Imaging" bpdmc.org

We're recruiting a Research Associate to join our Bioprocess Development team. This is a wet lab role ideally suited for someone graduating college this spring who is excited to join a team pioneering a new therapeutic modality Check it out! 👇 www.aiproteins.com/open-positio...