Andrew Saxe

@saxelab.bsky.social

Professor at the Gatsby Unit and Sainsbury Wellcome Centre, UCL, trying to figure out how we learn

If an action results in error, each neuron requires an individualized teaching signal that guides change in its output. This is the credit assignment problem of learning. Are there neurons in the brain that can compute such a sophisticated teaching signal? Yes. www.biorxiv.org/content/10.6...

Climbing fibers encode the gradient of a loss function for the cerebellum

Neurons in the brain are often many synapses away from motoneurons, yet if a movement results in error, each distant neuron needs a teacher that considers its specific contribution to production of th...

biorxiv.org

The lab is at @fens.org, with 5 posters — spatial & auditory working memory, prefrontal decision-making, dopamine in statistical learning, and a 2-photon rat-brain atlas for BrainGlobe. Unfortunately, I couldn't make it this year, but come find the rest of the lab on Tue, Thurs, & Fri! #FENS2026

Flyer — LIM Lab (Akrami Lab, Sainsbury Wellcome Centre / UCL) posters at FENS Forum 2026, Barcelona, 6–10 July. Tue 7 July board 129 (Arpit Agarwal); Thu 9 July boards 639 (Audra Rybak), 641 (Kyunghye Lee), 022 (Viktor Plattner); Fri 10 July board 353 (Lida Pentousi).

We’ve got an exciting new thing to share! We have causal evidence (using TMR) that memory reactivation during sleep promotes abstract understanding of underlying structure, allowing transfer learning in a new domain with zero superficial feature overlap with the learned one.

Sarah Solomon@sarahsolomon.bsky.social · 4mo ago

Super excited to share this preprint! How do we disentangle underlying structure from the particular features of a learning episode to benefit future learning? We find that memory reactivation during sleep promotes this structure abstraction process. www.biorxiv.org/content/10.6...

Excited to launch Principia, a nonprofit research organisation at the intersection of deep learning theory and AI safety. Our goal is to develop theory for modern machine learning systems that can help us understand complex network behaviors, including those critical for AI safety and alignment. 1