Just dropped- the paraventricular thalamus early-life stress story! 🧪🧠 so, activity of PVT neurons distinguished ELA from typical rearing. Amazingly the same activated cells execute the adverse impact of ELA on reward behaviors later in life. www.sciencedirect.com/science/arti.... Proud of the team
Holly Sullivan-Toole
@hollysully.bsky.social
Dev Affective Neuro, Reward, Reinforcement Learning, Anhedonia, Dopaminergic Circuitry, Brain Iron she/her
New diamond open access outlet for developmental psych. Free to publish, free to read, and led by a great team. One more step away from for-profit publishers.
I am pleased to announce the launch of our new diamond open access journal Psychology Across Development (accepting submissions starting today!). We are a lifespan developmental journal. (1/3) escholarship.org/uc/psycdev
Very excited to share our new preprint. We identify the basolateral amygdala dopamine system as an important interface between dynamic shifts in the environment and decisions to engage in vigorous drug use. Really challenging studies led brilliantly by Dr. Megan Brickner.
The basolateral amygdala dopamine system shapes dynamic drug seeking states
Drug-associated sensory cues and contexts exert powerful influence over drug seeking motivation, but in vivo brain mechanisms governing this process remain unclear. Here, we recorded and manipulated d...
biorxiv.org
Interdisciplinary research is great and necessary, and also has consistently lower funding success www.nature.com/articles/nat... #academiclabourmarket #academia #research
So… we just found out that GPT sol can complete a complex online behavioral/cognitive study producing nearly indistinguishable behavior and subjective reports… right as we are about to launch. Is this doomsday for online cognitive testing?
Just plugging my husband's instruments again! Check out Patrick Toole's personal-model violin and mandolin family instruments at: - Instagram: @toolestudios - Facebook: Toole Studios This viola and the mandolins in the videos below have found homes, but more where they came from!!
Just plugging my husband's instruments again! Check out Patrick Toole's personal-model violin and mandolin family instruments at: - Instagram: @toolestudios - Facebook: Toole Studios This viola and the mandolins in the videos below have found homes, but more where they came from!!
Seconded! Congrats @mattmattoni.bsky.social on the Flux Dissertation Award and an excellent talk!!!
An outstanding Dissertation Award talk by Matt Mattoni @mattmattoni.bsky.social on heterogeneity and idiographic (vs. nomothetic) approaches in developmental cognitive neuroscience. He made his case very well - and bonus: increased everyone's vocabulary! 👏 See more @ 1/ doi.org/10.1162/IMAG...
An outstanding Dissertation Award talk by Matt Mattoni @mattmattoni.bsky.social on heterogeneity and idiographic (vs. nomothetic) approaches in developmental cognitive neuroscience. He made his case very well - and bonus: increased everyone's vocabulary! 👏 See more @ 1/ doi.org/10.1162/IMAG...
Functional connectivity heterogeneity and consequences for clinical and cognitive prediction: Stage 2 registered report
Abstract. Functional connectivity is frequently used to assess dynamic brain functioning and predict individual differences in behavioral outcomes, such as psychopathology. Inferences from functional ...
doi.org
ICE has fallen out of the headlines but July marked the largest number of migrant detentions ever on record. Five migrants have died in ICE custody in the last two months. It's also currently impossible to legally migrate to this country, as 100% of visa applications have been paused.
A man and woman embrace as ICE and FHP detain her during an immigration stop in Fort Myers this morning.
When I was little *both* my grandmothers *each* explained to me that Dolly was a queen. Her voice. Her style. Her heart. Lots of comments about her philanthropy (which was gold) but she was an artist first—so authentically herself. Loving this deep cut. www.youtube.com/watch?v=D1TX...
Dolly Parton - The Bargain Store (Official Audio)
YouTube video by DollyPartonVEVO
youtube.com
Impressive network neuroscience work by Bene Ramirez @benediktramirez.bsky.social ! This allows the field to start discussing the nuances of discrete parcellation. It's gonna have big implications for precision interventions.
Excited to share our new preprint introducing Precision Confidence Mapping (PCM), a framework for estimating how confident we should be in individualized functional network assignments from resting-state fMRI. Why does this matter for precision neuromodulation? 🧵👇 www.biorxiv.org/content/10.6...
Excited to share our new preprint introducing Precision Confidence Mapping (PCM), a framework for estimating how confident we should be in individualized functional network assignments from resting-state fMRI. Why does this matter for precision neuromodulation? 🧵👇 www.biorxiv.org/content/10.6...
biorxiv.org
Psychology has been riding the intensive longitudinal train for a bit, but what about immunology? Now live @brainbehavimm.bsky.social, our physiometric report on the stability of inflammatory proteins collected every 3 days for 22 days during a natural stressor 1/X
Inflammatory Proteins are Highly Variable During a Natural Stressor: A Call for Intensive Longitudinal Blood Microsampling
Although research into how inflammation mediates the effects of stress on disorders such as heart disease and depression has grown rapidly, standard l…
sciencedirect.com
Loving my husband’s new viola style. Modern, distinct, butterscotch-y. www.givensviolins.com/product/viol...
Viola: 15 1/2" Patrick Toole, Philadelphia, PA 2024 | Claire Givens Violins, Inc
The Makers: Patrick studied violin making at the Newark School of Violin Making in England, where he developed a deep appreciation for craftsmanship and the beauty of natural materials. After spendin...
givensviolins.com
Study in 30,000 kids shows that unpredictable early-life experience is a potent Adverse Childhood Event www.nature.com/articles/s44.... Just dropped in Nature MH, with an amazing team. 🧪🧠 And unpredictability is actionable! would love your thoughts. @cate-cholamine.bsky.social @drkoraly.bsky.social
Unpredictability is a childhood adversity that contributes to mental health problems - Nature Mental Health
In this population-based cohort study, Glynn et al. tested the contribution of childhood unpredictability to mental health outcomes in ~30,000 participants, examining the relative and additive roles o...
nature.com
𝗕𝗥𝗘𝗔𝗞𝗜𝗡𝗚🚨 Prisciliano Trejo, aged 29 becomes the 50th person to die in #ICE custody. He was denied medical care until it was too late. His family was denied the ability to see him when he was finally sent to the hospital. This thread is one you must spend time on. We cannot ignore the atrocities!
Had the pleasure of joining ACAMH @acamh.bsky.social to discuss my research on how reinforcement learning changes across adolescence — and how it is altered by risk factors for psychopathology
What is #Anhedonia? What drives changes in reward responsiveness during adolescence? In this #MindtheKids podcast, we explore how adolescents learn from rewards and what this means for #depression risk and #mentalhealth outcomes with Holly Sullivan-Toole. https://bit.ly/4hcqSLk
the Cranberries EEiDI,SWCW is prob my #1 but this is on the list too!
Post a perfect album from the 90's that isn't Nirvana, Soundgarden, Pearl Jam, or Alice in Chains
Our new study ⬇️inspired by the question: does psilocybin influence meta-learning and cortical processing of unexpected uncertainty? Why is this important? Meta-learning may be critical for therapeutic effects of psychedelics and how the trip creates a window that facilitates clinical intervention
Come see this work and more at the Computational Psychiatry Conference tuesday morning poster session!!
🚨 preprint alert !!! Emotional and physical abuse have dissociable impacts on punishment learning and task engagement during adolescence osf.io/preprints/ps...
🚨 preprint alert !!! Emotional and physical abuse have dissociable impacts on punishment learning and task engagement during adolescence osf.io/preprints/ps...
Excited to share a paper recently accepted at Nature Mental Health! 😄 For decades, we've assumed that covariance among psychopathology informs comorbidity. What if we’ve been wrong?
Covariation among higher-order psychopathology dimensions is driven by nomorbidity, not comorbidity: https://osf.io/3t2cm
Covariation among higher-order psychopathology dimensions is driven by nomorbidity, not comorbidity: https://osf.io/3t2cm
Hi all! I’m looking for a full-time RA / lab manager (start date: late Aug or Sept, 1 year of funding guaranteed). Ideal candidate is a recent grad w/ relevant research experience. App review has begun, so if you’re interested, please apply here ASAP, by 7/12! Thx! phf.tbe.taleo.net/phf02/ats/ca...
Hiring Research Assistant, - Garden City, N.Y.
View job details and apply now
phf.tbe.taleo.net
Very happy to see this Review with @diegopizzagalli.bsky.social out in @cp-trendsneuro.bsky.social www.cell.com/trends/neuro... This piece brings together a lot of what we’ve been thinking on depression, predictive processing and EEG. Many thanks for the support from @sfb-trr-289.bsky.social
Brain rhythms of depression: A predictive processing perspective
Depression is marked by anhedonia, social withdrawal, and a diminished capacity to learn from positive experiences—features that can be framed within predictive processing. Here, we review findings fr...
cell.com
People with depression and anxiety symptoms are surprisingly better at overriding gut-instinct motivational biases, while those with compulsions and intrusive thoughts showed the opposite pattern, suggesting distinct motivational disruptions across psychiatric dimensions.
Adaptive suppression of motivational biases increases with mood/anxiety traits
Changes in motivational biases appear central to many psychiatric disorders including depression, anxiety, and substance abuse. Motivational biases, theorized to embody default response strategies…
biologicalpsychiatrycnni.org
“Every dollar invested in NIH-funded research returned about $2.50 to the broader economy — a 250% return on investment.” “…sustained NIH funding has generated more than $822 billion in economic activity, supported more than 3.7 million jobs” academicmedicine.aamc.org/stories/how-...
Client Challenge
academicmedicine.aamc.org