Holly Sullivan-Toole

@hollysully.bsky.social

Dev Affective Neuro, Reward, Reinforcement Learning, Anhedonia, Dopaminergic Circuitry, Brain Iron she/her

Very excited to share our new preprint. We identify the basolateral amygdala dopamine system as an important interface between dynamic shifts in the environment and decisions to engage in vigorous drug use. Really challenging studies led brilliantly by Dr. Megan Brickner.

The basolateral amygdala dopamine system shapes dynamic drug seeking states

Drug-associated sensory cues and contexts exert powerful influence over drug seeking motivation, but in vivo brain mechanisms governing this process remain unclear. Here, we recorded and manipulated d...

biorxiv.org

So… we just found out that GPT sol can complete a complex online behavioral/cognitive study producing nearly indistinguishable behavior and subjective reports… right as we are about to launch. Is this doomsday for online cognitive testing?

Just plugging my husband's instruments again! Check out Patrick Toole's personal-model violin and mandolin family instruments at: - Instagram: @toolestudios - Facebook: Toole Studios This viola and the mandolins in the videos below have found homes, but more where they came from!!

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Just plugging my husband's instruments again! Check out Patrick Toole's personal-model violin and mandolin family instruments at: - Instagram: @toolestudios - Facebook: Toole Studios This viola and the mandolins in the videos below have found homes, but more where they came from!!

Bild

Seconded! Congrats @mattmattoni.bsky.social on the Flux Dissertation Award and an excellent talk!!!

Dr. Jennifer Pfeifer@jenndsn.bsky.social · last mo.

An outstanding Dissertation Award talk by Matt Mattoni @mattmattoni.bsky.social on heterogeneity and idiographic (vs. nomothetic) approaches in developmental cognitive neuroscience. He made his case very well - and bonus: increased everyone's vocabulary! 👏 See more @ 1/ doi.org/10.1162/IMAG...

ICE has fallen out of the headlines but July marked the largest number of migrant detentions ever on record. Five migrants have died in ICE custody in the last two months. It's also currently impossible to legally migrate to this country, as 100% of visa applications have been paused.

amanda moore 🐢@noturtlesoup17.bsky.social · 2mo ago

A man and woman embrace as ICE and FHP detain her during an immigration stop in Fort Myers this morning.

𝗕𝗥𝗘𝗔𝗞𝗜𝗡𝗚🚨 Prisciliano Trejo, aged 29 becomes the 50th person to die in #ICE custody. He was denied medical care until it was too late. His family was denied the ability to see him when he was finally sent to the hospital. This thread is one you must spend time on. We cannot ignore the atrocities!

Had the pleasure of joining ACAMH @acamh.bsky.social to discuss my research on how reinforcement learning changes across adolescence — and how it is altered by risk factors for psychopathology

ACAMH - Association for Child and Adolescent Mental Health@acamh.bsky.social · 3mo ago

What is #Anhedonia? What drives changes in reward responsiveness during adolescence? In this #MindtheKids podcast, we explore how adolescents learn from rewards and what this means for #depression risk and #mentalhealth outcomes with Holly Sullivan-Toole. https://bit.ly/4hcqSLk

Our new study ⬇️inspired by the question: does psilocybin influence meta-learning and cortical processing of unexpected uncertainty? Why is this important? Meta-learning may be critical for therapeutic effects of psychedelics and how the trip creates a window that facilitates clinical intervention

People with depression and anxiety symptoms are surprisingly better at overriding gut-instinct motivational biases, while those with compulsions and intrusive thoughts showed the opposite pattern, suggesting distinct motivational disruptions across psychiatric dimensions.

Adaptive suppression of motivational biases increases with mood/anxiety traits

Changes in motivational biases appear central to many psychiatric disorders including depression, anxiety, and substance abuse. Motivational biases, theorized to embody default response strategies…

biologicalpsychiatrycnni.org