Study in 30,000 kids shows that unpredictable early-life experience is a potent Adverse Childhood Event www.nature.com/articles/s44.... Just dropped in Nature MH, with an amazing team. 🧪🧠 And unpredictability is actionable! would love your thoughts. @cate-cholamine.bsky.social @drkoraly.bsky.social

Unpredictability is a childhood adversity that contributes to mental health problems - Nature Mental Health

In this population-based cohort study, Glynn et al. tested the contribution of childhood unpredictability to mental health outcomes in ~30,000 participants, examining the relative and additive roles o...

nature.com

Brunch of champions

𝗕𝗥𝗘𝗔𝗞𝗜𝗡𝗚🚨 Prisciliano Trejo, aged 29 becomes the 50th person to die in #ICE custody. He was denied medical care until it was too late. His family was denied the ability to see him when he was finally sent to the hospital. This thread is one you must spend time on. We cannot ignore the atrocities!

Had the pleasure of joining ACAMH @acamh.bsky.social to discuss my research on how reinforcement learning changes across adolescence — and how it is altered by risk factors for psychopathology

ACAMH - Association for Child and Adolescent Mental Health@acamh.bsky.social · 2w ago

What is #Anhedonia? What drives changes in reward responsiveness during adolescence? In this #MindtheKids podcast, we explore how adolescents learn from rewards and what this means for #depression risk and #mentalhealth outcomes with Holly Sullivan-Toole. https://bit.ly/4hcqSLk

the Cranberries EEiDI,SWCW is prob my #1 but this is on the list too!

Matthias Warkus@matthias-warkus.de · last wk.

Post a perfect album from the 90's that isn't Nirvana, Soundgarden, Pearl Jam, or Alice in Chains

Our new study ⬇️inspired by the question: does psilocybin influence meta-learning and cortical processing of unexpected uncertainty? Why is this important? Meta-learning may be critical for therapeutic effects of psychedelics and how the trip creates a window that facilitates clinical intervention

Come see this work and more at the Computational Psychiatry Conference tuesday morning poster session!!

Holly Sullivan-Toole@hollysully.bsky.social · 4w ago

🚨 preprint alert !!! Emotional and physical abuse have dissociable impacts on punishment learning and task engagement during adolescence osf.io/preprints/ps...

🚨 preprint alert !!! Emotional and physical abuse have dissociable impacts on punishment learning and task engagement during adolescence osf.io/preprints/ps...

Excited to share a paper recently accepted at Nature Mental Health! 😄 For decades, we've assumed that covariance among psychopathology informs comorbidity. What if we’ve been wrong?

PsyArXivBot@psyarxivbot.bsky.social · 4w ago

Covariation among higher-order psychopathology dimensions is driven by nomorbidity, not comorbidity: https://osf.io/3t2cm

Covariation among higher-order psychopathology dimensions is driven by nomorbidity, not comorbidity: https://osf.io/3t2cm

Hi all! I’m looking for a full-time RA / lab manager (start date: late Aug or Sept, 1 year of funding guaranteed). Ideal candidate is a recent grad w/ relevant research experience. App review has begun, so if you’re interested, please apply here ASAP, by 7/12! Thx! phf.tbe.taleo.net/phf02/ats/ca...

Very happy to see this Review with @diegopizzagalli.bsky.social out in @cp-trendsneuro.bsky.social www.cell.com/trends/neuro... This piece brings together a lot of what we’ve been thinking on depression, predictive processing and EEG. Many thanks for the support from @sfb-trr-289.bsky.social

Brain rhythms of depression: A predictive processing perspective

Depression is marked by anhedonia, social withdrawal, and a diminished capacity to learn from positive experiences—features that can be framed within predictive processing. Here, we review findings fr...

cell.com

People with depression and anxiety symptoms are surprisingly better at overriding gut-instinct motivational biases, while those with compulsions and intrusive thoughts showed the opposite pattern, suggesting distinct motivational disruptions across psychiatric dimensions.

Adaptive suppression of motivational biases increases with mood/anxiety traits

Changes in motivational biases appear central to many psychiatric disorders including depression, anxiety, and substance abuse. Motivational biases, theorized to embody default response strategies…

biologicalpsychiatrycnni.org

“Every dollar invested in NIH-funded research returned about $2.50 to the broader economy — a 250% return on investment.” “…sustained NIH funding has generated more than $822 billion in economic activity, supported more than 3.7 million jobs” academicmedicine.aamc.org/stories/how-...

I'm really excited to share a new preprint! Lab studies have consistently shown that stress and negative emotions make people drink alcohol, but studies of daily life (EMA) keep failing to find it. What does that mean for the shared theoretical prediction both designs test? osf.io/preprints/ps...

We've known that socioeconomics (SES) matters for the 🧠. New & 🤯 is that SES drowns out all other brain associations, incl. IQ. If you train an algorithm to predict IQ from brain data, it's still way better at predicting SES. Science Mag: www.science.org/doi/10.1126/... @smarek0502.bsky.social 👀🧵👇

Scott Marek@smarek0502.bsky.social · 2mo ago

What matters most for childhood brain organization? We analyzed 649 variables. The answer: Socioeconomics (SES); with brain patterns pointing at sleep & stress as drivers. Even brain-IQ associations were better explained by SES. In Science today: www.science.org/doi/10.1126/...

How do we predict what’s going to happen next? In a new paper, we @arikahn.bsky.social @licezhang.bsky.social @nathanieldaw.bsky.social @catehartley.bsky.social ask how kids, teens, and adults solve this problem. onlinelibrary.wiley.com/doi/10.1111/...

Developmental Change in Structure Learning Reflects a Shift From Recency‐Based to Relational Prediction

Children are adept statistical learners, capable of parsing streams of structured input into meaningful units, but the cognitive processes they engage during learning may differ from those of adults...

onlinelibrary.wiley.com

some big news! hBayesDM has now been fully ported to cmdstan/cmdstanr/cmdstanpy check out the PR below, or the changelog for an overview: PR: github.com/CCS-Lab/hBay... Changelog: ccs-lab.github.io/hBayesDM/new... stay tuned for some additional features coming soon, including covariate support 🤓

feature: hBayesDM version 2.0 by Nathaniel-Haines · Pull Request #182 · CCS-Lab/hBayesDM

hBayesDM 2.0 — modernize stack & toolchain Top-to-bottom refactor of both the R and Python packages onto current Stan tooling, plus the supporting work to keep behavior, docs, and CI in sync. H...

github.com

What a stimulus predicts, not what it depicts, determines striatal reward signals www.biorxiv.org/content/10.6... This is interesting. nAcc responds most strongly to stimuli that predict reward, but vmPFC responds more to inherently pleasant (erotic 😳) stimuli.

Reproducible Human Reward Imaging Phenotypes Exhibit Differential Sensitivity to Dopamine D2 Receptor Antagonism https://www.biorxiv.org/content/10.64898/2026.05.14.724267v1

Recent preprint with Oriel FeldmanHall and Matt Nassar, showing clear neural evidence that adolescent (13-15 yrs) social media and smartphones use are associated with blunted reward signaling in the ventral striatum, the brain's reward processing hub, and worse mental health. osf.io/preprints/ps...

Selecting an effect size for power analysis is hard. Many researchers fall back on Cohen's thresholds, but they have no empirical basis and vary wildly by field. Our new paper offers a better option: field-specific effect size distributions built from meta-analytic data doi.org/10.3758/s134...

🚨Preprint Alert 🧠 Our new preprint „Menarche onset is an inflection point for mental health and brain development“ is now online! 👉 Preprint available here: www.biorxiv.org/content/10.6...

Very excited to announce our new preprint, led by @hollysully.bsky.social, that presents, benchmarks, and validates a method to estimate brain iron content from routine fMRI scans! It comes complete with a BIDS app! Check out the preprint and thread below! doi.org/10.64898/202...

Holly Sullivan-Toole@hollysully.bsky.social · 4mo ago

🚨Preprint Alert🚨 Our new preprint 'A Scalable fMRI Estimate of Basal Ganglia Brain Tissue Iron for Use in Developmental and Translational Neuroscience' is live!! lnkd.in/gpG9naba

Our new paper asks whether autism is linked to the way people learn from rewards. We’ve previously shown that people not only learn to value the features that predict reward, but also assign credit to features of their actions that they know are irrelevant (in this case, the card's location).

🚨Preprint Alert🚨 Our new preprint 'A Scalable fMRI Estimate of Basal Ganglia Brain Tissue Iron for Use in Developmental and Translational Neuroscience' is live!! lnkd.in/gpG9naba

Precision reward/affect fMRI study out now in HBM! onlinelibrary.wiley.com/doi/10.1002/... @dvsmith.bsky.social @olinotom.bsky.social @coopersharp.bsky.social and @shenghanwang.bsky.social Intensively sampled task + rest fMRI data with behavioral manipulation openly available on OpenNeuro! (1/2)

Precision Imaging for Intraindividual Investigation of the Reward Response

We present open data for an intensively sampled precision imaging study including multiple reward-related tasks and a behavioral mood manipulation. Our initial analysis found low test–retest reliabil....

onlinelibrary.wiley.com

Matt Mattoni@mattmattoni.bsky.social · 10mo ago

🚨🚨New precision imaging study and open dataset 🚨🚨 Featuring almost 200 functional runs acquired in 3-4d intervals and behavioral manipulations focused on intraindividual study of the reward response - The Night Owls Scan Club (NOSC) With @dvsmith.bsky.social and @olinotom.bsky.social!

USPS announced that it would no longer postmark mail automatically on the date it is received. Voting rights advocates fear that this may end up disenfranchising voters who rely on postmark dates, and they’re urging people to get ahead of election deadlines.

In an Intense Election Year, New Post Office Rules Could Trip Up Voter Registration - Bolts

A change in how mail is postmarked could lead some voters to miss key deadlines, including voter registration. Advocates worry the people most affected will be those already facing voting barriers.

boltsmag.org

🚨 New preprint alert! 🚨 Transdiagnostic latent factor models of psychopathology are widely assumed to improve brain-behaviour associations. So we decided to test this directly and found that they don't. A short 🧵 Link: www.biorxiv.org/content/10.6... 1/10

New preprint from the lab! Led by @martingell.bsky.social . There is something for everyone: brain-behavior prediction, latent variable modeling, test-retest reliability. 🧠📈📊 "Disentangling Brain-Psychopathology Associations: A Systematic Evaluation of Transdiagnostic Latent Factor Models"

Martin Gell@martingell.bsky.social · 5mo ago

🚨 New preprint alert! 🚨 Transdiagnostic latent factor models of psychopathology are widely assumed to improve brain-behaviour associations. So we decided to test this directly and found that they don't. A short 🧵 Link: www.biorxiv.org/content/10.6... 1/10