Inflammatory Astrocytography 🔬🌈 Giving new life to residual images from experiments is a way of looking again at what science leaves unseen. Yesterday, my image won 2nd place at the annual meeting of the Centro Interdisciplinario de Neurociencia de Valparaíso (CINV).Happy to show the beauty of brain

Very happy to share our new paper, where I am first author, developed at University of Chile. Astrocytes were long overlooked as passive “support” cells, yet they play key roles in brain responses. We explore how neuroinflammation alters astrocyte behaviour. ⚗️🧫🧪 link.springer.com/article/10.1...

Neuroinflammation-induced downregulation of RAB7 in murine astrocytes disrupts endo-lysosomal homeostasis and induces astrogliosis - Cell Communication and Signaling

Background Neuroinflammation induces astrogliosis, a process marked by astrocyte hypertrophy, increased migration, and altered protein expression. While these changes involve both up- and downregulati...

link.springer.com

Collective migration is not just about leaders at the front, but about coordination across the group. Always exciting to see these dynamics visualized. Many thanks to @jcb.org for featuring our work 🐸🔬🌹

Journal of Cell Biology@jcb.org · 6mo ago

🔬 From our March issue (rupress.org/jcb/issue/22...): Epithelial neural collectives undergoing #chemotaxis, stained for phospho-#myosin (magenta), #actin (cyan), and nuclei (yellow). From @jorgediazfuentes.bsky.social and @mayorlab.bsky.social: rupress.org/jcb/article/...

Collectivity is not uniformity—it’s the coordination of forces under tension. In Xenopus neural crest epithelial clusters, movement emerges from within. From my postdoctoral research: nuclei (red), membranes (magenta), cytoskeleton (green). No internal tension, no collective motion. Tension holds 🐸🔬

Force coordination distinguishes epithelial and mesenchymal modes of collective #chemotaxis. New study from Jorge Diaz and Roberto Mayor @mayorlab.bsky.social @ucl.ac.uk: rupress.org/jcb/article/... #Migration #motility #Development

Delighted to see our JCB work (rupress.org/jcb/article/...) beautifully summarized by Bits & Species Mesenchymal and Epithelial-like Xenopus Neural Crest clusters use distinct force architectures to achieve comparable chemotactic performance 🐸🔬🧬🧫 IG feature: www.instagram.com/p/DUlACAJERdA/

Two ways to move together: force coordination in collective #chemotaxis. Jessica Pacheco & Erica Hutchins @drericabiophd.bsky.social @ctbatucsf.bsky.social discuss study from @jorgediazfuentes.bsky.social & @mayorlab.bsky.social (rupress.org/jcb/article/...) in Spotlight rupress.org/jcb/article/...

Diaz and @mayorlab.bsky.social show that epithelial and mesenchymal cells navigate chemical cues via fundamentally different force-generating mechanisms, offering new insight into how diverse cell types achieve collective movement during development and disease. rupress.org/jcb/article/...

Honored to see our work featured in a JCB Spotlight by Pacheco and @drericabiophd.bsky.social (@UCSF). The piece discusses our study revealing distinct force-generating mechanisms in epithelial and mesenchymal collective migration 🔬🐸 Thank you for your careful review of our work! hubs.la/Q042GFYY0

Journal of Cell Biology@jcb.org · 8mo ago

Pacheco & @drericabiophd.bsky.social discuss new study from @jorgediazfuentes.bsky.social & @mayorlab.bsky.social (rupress.org/jcb/article/...) which reveals the distinct force-generating mechanisms used by epithelial and mesenchymal cells during collective cell migration rupress.org/jcb/article/...

So proud to share my paper on collective chemotaxis and force coordination in epithelial and mesenchymal cells, developed in the Mayor Lab and now published in JCB. Deeply grateful for everything I learned from Xenopus NC and the amphibian world, where adaptation is everything🐸

International Society of Developmental Biology@isdb.bsky.social · 8mo ago

A new paper published in @jcb.org by postdoc Jorge Diaz from the Mayor lab at UCL shows that during collective migration, epithelial-like clusters generate traction force mainly through cryptic protrusions at the centre, while mesenchymal clusters do so at their periphery: doi.org/10.1083/jcb....

A new paper published in @jcb.org by postdoc Jorge Diaz from the Mayor lab at UCL shows that during collective migration, epithelial-like clusters generate traction force mainly through cryptic protrusions at the centre, while mesenchymal clusters do so at their periphery: doi.org/10.1083/jcb....