Very cool preprint by @pablotaboas.bsky.social and team www.biorxiv.org/content/10.6... Very happy to have you in the lab, Pablo!

USP7 sustains PAX3::FOXO1 enhancer reprogramming and represents a therapeutic vulnerability in Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and is often associated with dismal outcomes, underscoring the urgent need for new therapeutic strategies. RMS arises from emb...

biorxiv.org

USP7 sustains PAX3::FOXO1 enhancer reprogramming and represents a therapeutic vulnerability in Rhabdomyosarcoma https://www.biorxiv.org/content/10.64898/2026.06.03.724934v1

USP7 sustains PAX3::FOXO1 enhancer reprogramming and represents a therapeutic vulnerability in Rhabdomyosarcoma https://www.biorxiv.org/content/10.64898/2026.06.03.724934v1

Really happy to have participated in this paper where we describe the role of PRKG1 as a clinical biomarker for Ipatasertib therapy in Rhabdomyosarcoma. Congratulations to everyone involved, and especially to Estela Prada, PhD for leading this great study. www.nature.com/articles/s41...

PRKG1 hinders myogenic differentiation and predicts response to AKT inhibitor ipatasertib in Rhabdomyosarcoma - Nature Communications

Despite frequent AKT/mTOR pathway activation in patient’s rhabdomyosarcoma (RMS), success of AKT inhibitors in the clinical has been limited. Here, using RMS patient-derived models, the authors demons...

nature.com

Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances chemotherapy efficacy in Ewing sarcoma https://www.biorxiv.org/content/10.1101/2025.08.07.669049v1

The new findings of Alina Ritter showcase that this approach may be especially feasible for metastatic disease since an impirtant viral docking site is highly expressed in metastatic lesions and even contributes to metastasis in #Ewing #sarcoma. We will not stop until there is a cure!

Based on the neomorphic DNA-binding capabilities of the Ewing sarcoma-specific EWSR1::ETS fusion oncoproteins, our expression constructs can deliver specifically produg convertases, (neo)-antigens, and cytokines to induce cell death only in Ewing cells, i.e. turn a 'cold' tumor 'hot'.

Since CXADR is a viral receptor, this study further paves the way for our novel virotherapy of #Ewing #sarcoma based on our 2022 study by @hoelting.bsky.social pioneering a suicde gene therapy induced by a Ewing sarcoma-specifc synthetic GGAA-enhancer tinyurl.com/2sckk89m

Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma - Molecular Cancer

Chimeric fusion transcription factors are oncogenic hallmarks of several devastating cancer entities including pediatric sarcomas, such as Ewing sarcoma (EwS) and alveolar rhabdomyosarcoma (ARMS). Des...

tinyurl.com

Very proud on our stellar Alina Ritter for her frist first-author paper: Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances #chemotherapy efficacy in #Ewing #sarcoma tinyurl.com/3kcs3bc9 @dkfz.bsky.social @uniheidelberg.bsky.social @nct-heidelberg.bsky.social

So proud on our stellar medical student Florian H. Geyer for his first first-authorship paper! Comprehensive #DSRCT multi-omics analyses unveil CACNA2D2 as a diagnostic hallmark and super-enhancer-driven EWSR1::WT1 signature gene tinyurl.com/42fxmmud @dkfz.bsky.social @uniheidelberg.bsky.social