Grünewald Lab
@grunewaldlab.bsky.social
Division of Translational Pediatric Sarcoma Research @DKFZ
New liver-specific mechanism of immune evasion: Palmitate promotes via DHHC17 laminin-511 secretion, which disables the antitumor function of neutrophils & supports liver metastasis. Big congratulations to Anke Vandekeere and all co-authors! 🎉 bit.ly/4yXHVap #Metastasis #Immunology #FWO #KOTK
SPARK-ID: Dynamic DSB-sensor interactomes reveal modular nuclear repair networks coordinated by connector proteins www.biorxiv.org/content/10.6...
SPARK-ID: Dynamic DSB-sensor interactomes reveal modular nuclear repair networks coordinated by connector proteins
DNA double-strand breaks (DSBs) activate repair pathways that must be coordinated with other cellular functions. Although DSB sensors SIRT6, Ku80, and MRE11 initiate repair, how they organize these nu...
biorxiv.org
Der mit bis zu 600 fossil betriebenen PS blechgewordene pubertäre Poserfiebertraum von Audi, der SuperSUV Q9, ist lang wie ein Transporter, breit wie ein Junkie, höher als der Durchschnittsdeutsche—ein Auto wie ein wütend erhobener Mittelfinger-Epitaph auf unserem Grabstein als vernunftbegabte Wesen
Many people have never heard of sarcoma until it becomes part of their lives. The first challenge is often simply understanding what it is, where to find reliable information, and how to navigate a healthcare systems. Joost's story reminds us why patient-focused information and support matter.
10% der Ernte verloren und immer noch Jubelton von „geknackten Hitzerekorden“ und Mega-Badewetter. So ist das halt wenn Medien unter dem Einfluss fossiler Denke stehen. Es ändert jedoch nichts daran, dass wir bei aktuellem Klimatrend bis 2050 bis zu 50% Ernteverlust = 5-10%BIP in Deutschland erleben
A single-cell atlas of cancer-educated ecotypes across high-risk pediatric sarcomas #SingleCell 🧪🧬🖥️ https://www.researchsquare.com/article/rs-10374394/latest
Cancer prevention is fundamental to reducing global disease burden. This review explores signaling pathways, chemopreventive agents, and precision strategies to prevent #Cancer initiation and progression. #STTT #OpenAccess: doi.org/10.1038/s413... #CellSignaling #Oncology #CancerBiology
🔥Check out our new preprint from @KiTZ: A single-cell atlas of cancer-educated ecotypes across high-risk pediatric sarcomas >800K nuclei profiled! @dkfz.bsky.social @nct-heidelberg.bsky.social @uniheidelberg.bsky.social assets-eu.researchsquare.com/files/rs-103...
Can metabolic reprogramming strengthen #Cancer #Immunotherapy? This study shows a photoresponsive Nano-PROTAC enhances pyroptosis-mediated antitumor immunity and suppresses triple-negative #BreastCancer progression. #STTT #OpenAccess: doi.org/10.1038/s413...
Interesting analysis. Make one wonder if journals are necessary anymore.
Grünewald Lab@grunewaldlab.bsky.social · 4w ago
@natgenet.nature.com is looking to hire a Cancer editor! Please repost and share with your contacts! This is a rare and exciting opportunity. springernature.wd3.myworkdayjobs.com/SpringerNatu...
Associate or Senior Editor, Nature Genetics
Job Title: Associate or Senior Editor, Nature Genetics Location: Shanghai, Beijing, Madrid, Milan or Pune, Hybrid Working Model Application Deadline: Aug 3rd, 2026 About Springer Nature Springer Natur...
springernature.wd3.myworkdayjobs.com
📣Very proud on our PhD student Angelina Yershova who was awarded with the best talk prize 🏆 at the Advances in Ewing Sarcoma Research (AESR) conference in London, UK @bcrt-uk.bsky.social @dkfz.bsky.social
“move from preprint to peer-reviewed publication leaves the central claims of most abstracts intact, indicating preprints are a reliable source…papers that were never posted as preprints were retracted at roughly twice the rate of those that were…” www.biorxiv.org/content/10.6...
Tracking claim changes from preprint to publication across 72,644 biomedical studies using large language models
Preprints now disseminate a large share of biomedical research before peer review. Because they have not yet passed peer review, some scientists regard preprint claims as unverified or potentially unr...
biorxiv.org
Genomic landscape of Ewing sarcoma: a pooled analysis of 538 cases and clinicopathological correlation https://www.medrxiv.org/content/10.64898/2026.06.29.26356801v1
Mit den "Proof of Concept"-Grants unterstützt der Europäische Forschungsrat Wissenschaftler:innen dabei, das wirtschaftliche Potential ihrer Forschungsergebnisse weiterzuentwickeln. Auch 2026 wurden wieder zwei DKFZ-Wissenschaftler für die Förderung ausgewählt.👏 #ERCPoC @erc.europa.eu t1p.de/oqp8c
Doppelter ERC-Erfolg für DKFZ-Forscher
Mit seinen „Proof of Concept“ (PoC)-Grants unterstützt der Europäische Forschungsrat (ERC) Wissenschaftler dabei, das wirtschaftliche Potential ihrer Forschungsergebnisse weiterzuentwickeln. Auch 2026...
t1p.de
#STTT has achieved an outstanding #ImpactFactor of 81.2 and advanced to Q1 in the latest Journal Citation Reports, ranking No. 1 in Biochemistry & Molecular Biology and No. 2 in Cell Biology. We are grateful for your support & contributions to this achievement. Visit: www.nature.com/sigtrans/
Konzert: Chormusik aus dem Ostseeraum – Camerata Carolina präsentiert am 28. Juni 2026 romantische und zeitgenössische Kompositionen www.uni-heidelberg.de/de/newsroom/... #universität #heidelberg #uniheidelberg #cameratacarolina #chormusik #konzert
Our work now out @natcomms.nature.com: #PDAC is wired for #necroptosis due to oncogenic #KRAS. @unicologne.bsky.social @cecad.bsky.social @uniklinikkoeln.bsky.social with fantastic collaborators and superstar first author Sofya Tishina! rdcu.be/foDxS
Oncogenic KRAS-driven type I interferon signalling primes pancreatic cancer for necroptosis
Nature Communications - The regulatory roles of oncogenic KRAS in cell death pathways remain poorly understood. Here the authors report that KRAS induces a type I interferon response that primes...
rdcu.be
Impressive work by @enriquedealava.bsky.social lab on EXO1 in Ewing sarcoma www.biorxiv.org/content/10.6...
EXO1 Facilitates MiDAS and Prevents Genome Instability and Cell Death in Ewing Sarcoma
Ewing sarcoma (EwS) is an aggressive malignancy driven by EWSR1::ETS fusions, predominantly EWSR1::FLI1. Previous efforts using both direct and indirect approaches to target these chimeric oncoprotein...
biorxiv.org
EXO1 Facilitates MiDAS and Prevents Genome Instability and Cell Death in Ewing Sarcoma https://www.biorxiv.org/content/10.64898/2026.06.05.730187v1
Very cool preprint by @pablotaboas.bsky.social and team www.biorxiv.org/content/10.6... Very happy to have you in the lab, Pablo!
USP7 sustains PAX3::FOXO1 enhancer reprogramming and represents a therapeutic vulnerability in Rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and is often associated with dismal outcomes, underscoring the urgent need for new therapeutic strategies. RMS arises from emb...
biorxiv.org
USP7 sustains PAX3::FOXO1 enhancer reprogramming and represents a therapeutic vulnerability in Rhabdomyosarcoma https://www.biorxiv.org/content/10.64898/2026.06.03.724934v1
Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...
mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.
cell.com
We are happy to announce that our article on the impact of #superovulation and #aging on mouse #oocyte and #granulosa cells is out in Nature Communications! www.nature.com/articles/s41...
Incredible! Scientists receive a rare standing ovation after announcing that a new treatment can double the survival time for pancreatic cancer, the deadliest cancer which was once considered “undruggable.” When we fund and support science, we can achieve anything! (Video: Dr. Wish Dhillon)
👏Moritz Mall receives Sibylle Assmus Price for neuro-oncology – dotation of 15.000 € – for his project „SAFE-GBM – Decoding the Repressive Architecture that limits Glioblastoma Plasticity“. @dkfz.bsky.social Zentralinstitut für Seelische Gesundheit www.dkfz.de/en/news/pres...
Please RT: Opportunity to join us as technician! We are looking for a technician to support us in our projects in MPN and other myeloid malignancies using epigenomics on primary samples and PDX mouse models. Where: @carrerasijc.bsky.social When: Anytime. What: 👉https://sl1nk.com/0ekf3z6
Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances chemotherapy efficacy in Ewing sarcoma www.biorxiv.org/content/10.1...
Interessant. Selbst das ManagerMagazin, das wohl niemand als links oder grün oder wirtschaftsfeondlich verdächtigt, spricht Tacheles über die fossile Ideologie und Zerstörungswut der GasMinisterin #fossilMafia
