New out this week in @natmetabolism.nature.com – We measured dynamic aspartate changes following mitochondrial inhibition, finding that SDH inhibition causes a counterintuitive "aspartate rebound" effect, mediated by succinate impairing pyrimidine synthesis. www.nature.com/articles/s42...

Succinate dehydrogenase loss suppresses pyrimidine biosynthesis via succinate-mediated inhibition of aspartate transcarbamylase - Nature Metabolism

Succinate acts as a competitive inhibitor of mammalian aspartate transcarbamylase (ATCase), leading to impaired pyrimidine biosynthesis and reduced proliferation under SDH inhibition.

nature.com

Check out our latest work out today in @natmetabolism.nature.com in which we describe a new metabotype (metabolic phenotype): excess cysteine stress. We discovered novel cysteine conjugates and show how pyruvate modulates free intracellular cysteine levels. Grateful for an awesome team!!

Nature Metabolism@natmetabolism.nature.com · 4mo ago

Big congratulations to @jenniferabrain.bsky.social, Anna and the Sullivan squad for their awesome story, now published in Nature Metabolism!!

Lucas Sullivan@lucasbsullivan.bsky.social · 4mo ago

Pleased to share our recent work out today in @natmetabolism.nature.com. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?

Thank you for this awesome preLight!! Looking forward to sharing some more answers in our revised manuscript 🤩

Natalie Niemi@nieminm.bsky.social · last yr.

Niemi lab graduate student Hannah Pletcher recently joined @prelights.bsky.social and wrote nice highlight of recent work from @lucasbsullivan.bsky.social - check it out here!

Next, our 2nd preprint of the week (!), this one driven by @madelouhart.bsky.social Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability. Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!

bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis https://www.biorxiv.org/content/10.1101/2025.02.18.638948v1