What if you had a light-triggered starting gun for #CRISPR diagnostics? Meet LUCas, a light-controlled #Cas13a system that stays silent until you need it. Now published in @narjournal.bsky.social. Congrats to all the authors! #moleculardiagnostics academic.oup.com/nar/article/...

LUCas: Light-Uncaged Cas13a using photocleavable interfering guide RNAs

Abstract. CRISPR diagnostics enable sensitive detection of infectious diseases, with the RNA endonuclease Cas13a providing specific, amplification-free RNA

academic.oup.com

Congratulations to Carlos (@carlosfng.bsky.social) for being a recipient of the 2026 Outstanding Graduate Student Peer Mentor Award. Images courtesy of Laure Andrillon.

In our new work published in @natbiomedeng.nature.com in collaboration with @theottlab.bsky.social and @doudna-lab.bsky.social, we introduce "interfering" guide RNAs (igRNA) for CRISPR-Cas13a that regulate enzyme activity after activation. Congrats to all the authors! www.nature.com/articles/s41...

Programmable kinetic barcoding for multiplexed RNA detection with Cas13a - Nature Biomedical Engineering

A multiplexed RNA detection method exploits crRNA-dependent variability in Cas13a activity on RNA targets for kinetic barcoding and can be used to distinguish among SARS-CoV-2 variants in clinical sam...

nature.com

Check out our latest preprint: LUCas! A direct light control of Cas13 trans-cleavage activity. Congrats to all the authors: Carlos (@carlosfng.bsky.social), Deepak (@deepakkrish.bsky.social), Andres, and Aymeric. www.biorxiv.org/content/10.6...

Congratulations Caitlin! #trogocytosis #macrophages

Fletcher Lab@fletcherlabucb.bsky.social · 11mo ago

How does a macrophage decide to eat or simply nibble? Check out our latest paper! You can also read this nice review. Congrats Caitlin for leading this amazing work! www.nature.com/articles/s41... www.nature.com/articles/s41...

Hola Bluesky!