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Ariana Costas

@arianacostas.bsky.social

PhD candidate at @aimi-UTS.bsky.official and Institut Cochin, investigating the antibiotic non-response of uropathogenic E. coli during UTI🔬🧫🦠

4 Posts124 Follower296 Folgt
Prof Jenny Rohn@jennyrohn.bsky.social · 12mo ago

People spend loads on #UTI preventions that aren’t truly effective, like D-mannose. £19.99 only buys you a 2-week course. The rest of the products on display were similarly expensive and unlikely to do much. We need better therapies! (See Alt text for source of negative D-mannose RCT) #UTISky

A packet of D-mannose being advertised in Boots for recurrent UTI, 14 sachets for £19.99. Best part of £40 a month.The conclusions from an abstract from a recent RCT (Hayward et al. 2024, doi: 10.1001/jamainternmed.2024.0264) “Conclusions and relevance: In this randomized clinical trial, daily d-mannose did not reduce the proportion of women with recurrent UTI in primary care who experienced a subsequent clinically suspected UTI. d-Mannose should not be recommended for prophylaxis in this patient group. Trial registration: isrctn.org Identifier: ISRCTN13283516.”
NCCR AntiResist@nccr-antiresist.bsky.social · 2y ago

Congratulations to @carlosebflores.bsky.social on his latest publication with @jennyrohn.bsky.social, "Bacterial adhesion strategies and countermeasures in urinary tract infection" in @naturemicrobiol.bsky.social Read it here 👉 www.nature.com/articles/s41...

Bacterial adhesion strategies and countermeasures in urinary tract infection - Nature Microbiology

This Review discusses adhesion strategies of bacterial pathogens causing urinary tract infections, and outlines host responses and recent advances in therapeutic strategies targeting bacterial adhesio...

nature.com

Ariana Costas@arianacostas.bsky.social · 2y ago

A new review for some Thursday morning reading! This paper details the elements needed to develop relevant physiologic models of the bladder and discusses current technology. Very grateful to have been a part of this review! Happy reading, everyone! #UTIsky #UTI www.nature.com/articles/s41...

A bladder blueprint to build better models for understanding homeostasis and disease - Nature Reviews Urology

In this Review, the authors present the development, structure and microenvironment, and defence mechanisms of the bladder, which together create a blueprint that can be used to optimize current model...

nature.com

Bill Söderström@bill-lab.bsky.social · 2y ago

Need a break from the Christmas food? Check out the latest supercool ex-vivo UTI model from the ingersoll lab @immunobladder.bsky.social www.biorxiv.org/content/10.1...

A simple ex vivo bladder infection model permits study of host-pathogen interactions in UTI

Urinary tract infections (UTI) are one of the most common infections, worldwide. To understand mechanisms of UTI pathogenesis and find new treatments, researchers often use animal models, such as mice...

biorxiv.org

Rebecca J Hall@drrebeccajhall.bsky.social · 2y ago

🚨 New preprint 🚨 With two excellent students Shalini Choudhary and Jacob Smith, we started looking at how the metabolic microenvironment of the urinary tract might affect uropathogenic E. coli evolution and response to antibiotics. www.biorxiv.org/content/10.1...

Glucose alters the evolutionary response to gentamicin in uropathogenic Escherichia coli

Urinary tract infections (UTI) are a major health and economic concern. Uropathogenic Escherichia coli (UPEC) are the leading cause of UTI, and antibiotic resistant UPEC are increasingly common. The m...

biorxiv.org

Katy Patras@katypatras.bsky.social · 2y ago

Why is preterm birth risk doubled with maternal UTI? It depends on the immune response. We found distinct immune signatures in a UTI-associated preterm birth mouse model. In a human cohort from @AShea_Lab, urine cytokine levels could predict preterm birth. www.biorxiv.org/content/10.1...

Distinct maternofetal immune signatures delineate preterm birth onset following urinary tract infection

Preterm birth is the leading cause of infant mortality resulting in over one million neonatal deaths annually. Maternal urinary tract infection (UTI) during pregnancy increases risk for preterm birth;...

biorxiv.org