Get your online ChemBio fix in September - thanks to the Leiden crowd for organising, now the 6th edition!

Virtual ChemBioTalks@chembiotalks.bsky.social · 4mo ago

Registration is now open for the 6th Virtual ChemBioTalks on September 29th from 12:00 to 18:00 CEST. We have an amazing program for you highlighted by our keynotes @supertifurgalab.bsky.social and Michelle Chang. Make sure to register to not miss it: events.zoom.us/ev/Ag1AUcW3n...

TUD lecture series “Frontiers in Science” on June 25: Chemist Prof. Seth M. Cohen from @uofcalifornia.bsky.social will give a lecture on his research into metalloenzymes. 💊 It is called “Combining Medical and Inorganic Chemistry – From the Lab to the Bedside.” ℹ️ tu-dresden.de/tu-dresden/e...

Most cited manuscripts from @nioxjournal.bsky.social A comparison of the chemical biology of hydropersulfides (RSSH) with other protective biological antioxidants and nucleophiles By Jon Fukuto and Adrian Hobbs

Now it's official! Our DFG funded Collaborative Research Center on Membrane Complexes will be funded for another round! 🥳🥳🥳 For our lab that means more exciting work on TRP channels and their role as cellular signaling hubs 😍 @crc1507.bsky.social www.dfg.de/de/aktuelles...

Internship / MSc for #engineering, #photoswitch & #optogenetics fans: Like LEDs, soldering, simple PCBs and optics? Join the Thorn-Seshold lab at @tudresden.bsky.social & help build next-gen light engines for #photopharmacology & cellular control. PIs please repost! @poldresden.bsky.social

Proof of principle vs. translational reality check: Can we accumulate nano-formulated drugs inside solid tumours by transiently disrupting tumour vasculature? Yes, in principle, but with a translational catch 👇 #GO-Bio #BMFTR @lmu.de; #ChemBio bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

BPS Publications

Background and purpose Nano-formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredi...

bpspubs.onlinelibrary.wiley.com

GBM Lunch on May 6, 2026, 12:30 Speaker: Youjun Yang (East China University of Science and Technology) Title: "Early Ferroptosis Detection Targeting Lipid Hydrogen Abstraction” Chair: @oliverthornseshold.bsky.social Organizer: Joint Study Group "Chemical Biology" #GBMLunch #ChemicalBiology

This week’s Essential Read in #chembio - my vote: what actually happens to diazirine photolabels? @nadlerlab.bsky.social strikes again. Enjoy #photopharma and caveat N2or! pubs.acs.org/doi/10.1021/...

Bifunctional Lipid–Protein Cross-linking Efficiency and Reaction Products

Bifunctional diazirine lipids are versatile tools for mapping protein–lipid interactions and cellular localization by photo-cross-linking. Yet, the cross-linking efficiency of these probes has not bee...

pubs.acs.org

Youjun Yang and coworkers did a great chemical probe design paper: Fluorogenicity cleverly triggered by H-atom abstraction. Congrats to all! #chembio #fluorescencefriday #realtimechem pubs.acs.org/doi/10.1021/...

Early Ferroptosis Detection Targeting Lipid Hydrogen Abstraction

Ferroptosis is an Fe2+-dependent and lipid peroxidation-mediated regulated cell death. Its early detection is critical for diagnosis and timely intervention. Lipid hydrogen abstraction is the initiati...

pubs.acs.org

Understanding the thioredoxin system is key to understanding cellular RedOx homeostasis. Congratulations to @lzeisel.bsky.social on being awarded one of the @gdchbiochem.bsky.social Young Scientist Awards for his work in the @thornsesholdlab.bsky.social in this field. pubs.acs.org/doi/abs/10.1...

We are excited that we could today award four Young Scientist Awards for outstanding publications and dissertations over the last two years. The awardees are Johannes Morstein, Sarah Emmert, Frederik Schmidt and Lukas Zeisel. Congratulations to all awardees! (1/3) #Biochemistry #ChemSky #ChemBio

Excited to share our new Perspective in @natchembio.nature.com with @Yang_J_lab. How do we move from isolated cysteine modifications to a systems-level understanding of redox signaling? We outline a unified chemical framework for decoding the cysteine redoxome. Read here: t.co/6XY1FCdtN6

Chemical biology PhDs/postdocs: don't miss out! Liz New is hiring a 2-year postdoc position on making & using fluorophores, in Sydney, Australia. A great group in a great city. #chembio #postdoc hunters - check out the @lizjnew.bsky.social lab for more. usyd.wd105.myworkdayjobs.com/en-US/USYD_E...

Postdoctoral Research Associate in Chemical Biology

Full time, 2 years fixed term Located at the School of Chemistry on the Camperdown Campus Opportunity to contribute to multidisciplinary research on new mitochondrial targeting agents Base Salary, Lev...

usyd.wd105.myworkdayjobs.com

Important paper alert #molswitches & #photopharma! Thorough, clear, fundamental mechanistics. Congratulations to @screspi.bsky.social @nadjasimeth.bsky.social and all involved!

Stefano Crespi@screspi.bsky.social · 8mo ago

Check out our latest publication in @angewandtechemie.bsky.social where we show that the infamous V shape in the substituent effects in the thermal isomerization of azobenzenes comes from a single nonadiabatic mechanism 🔥 and not a mix of two. onlinelibrary.wiley.com/doi/10.1002/...

#chembio and #bioorganic crowd: Registration to ESBOC is open. Join us on 27th-29th May for the oldest meeting in chemical biology in Europe, at the awesome Schlosshotel Pillnitz in Dresden! Check out www.esboc.org.uk or register directly at eveeno.com/esboc2026!

European Symposium on Biological and Organic Chemistry (ESBOC) 2026

eveeno.com

Ben Schumann@drglycoben.bsky.social · 9mo ago

#chembio and #bioorganic crowd. Mark your calendars for ESBOC 2026, registration opens soon! www.esboc.org.uk ⏱️ 27th-30th May 2026 🏰 The beautiful Schlosshotel Pillnitz GmbH in Dresden/Germany

Thank you @compoundchem.com for recognizing the women of chemistry! A few years back you featured >180 present day women chemists, including me. www.compoundchem.com/women-in-che... You are the best!

Women in Chemistry

Over the years, I've made a number of graphics highlighting important women in chemistry history. But highlighting and supporting women in chemistry isn't just about pointing to historical figureheads...

compoundchem.com

Compound Interest | Chemistry infographics@compoundchem.com · 8mo ago

Today is the #InternationalDayOfWomenAndGirlsInScience 👩‍🔬 This graphic highlights women of the periodic table, the elements they discovered, and the two elements named after women. Plenty more graphics on women in chemistry here: www.compoundchem.com/category/wom... #ChemSky 🧪

🎨 „Colourful Chemistry" – unter diesem Motto lädt das JCF der GDCh vom 10.–13. März nach Köln. 400 junge Forschende, Plenarvorträge, Workshops und erstmals der JCF Best Supervisor Award. Erste Preisträgerin: Prof. Lena Daumann. gdch.app/article/colo...

Colourful Chemistry: Frühjahrssymposium zeigt Vielfalt der Chemie

Unter dem Motto „Colourful Chemistry” findet vom 10. bis 13. März in Köln das Frühjahrssymposium des JCF (JungesChemieForum) der Gesellschaft Deutscher Chemiker (GDCh) statt. Die Tagung richtet sich a...

gdch.app

#photoswitches: How should we determine errors on PSS distributions, and the absorption spectrum of the metastable isomer? We have been discussing this for years and have finally written a manuscript, including a python code to fit your data without human bias. chemrxiv.org/doi/full/10....

Out now in @natchembio.nature.com: Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells 🎉 www.nature.com/articles/s41... check out the press release below! #glycotime

Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells - Nature Chemical Biology

The xylosyltransferase isoenzymes XT1 and XT2 catalyze the first glycosylation step in the biosynthesis of proteoglycans. Now, bump-and-hole engineering of XT1 and XT2 enables substrate profiling and ...

nature.com

The Francis Crick Institute@crick.ac.uk · 9mo ago

Researchers at the Crick, @imperialcollegeldn.bsky.social and @tudresden.bsky.social have worked out a method to track and analyse complex molecules that sense external messages crucial for cell growth and behaviour. www.crick.ac.uk/news/2026-01...

🧪If you love lipids,cell biology & chemical bioloy and wonder about the fundamental mechanisms of life, you'll be in for a treat! 🤩🥳 Don't miss the next @gbmev.bsky.social Lunch Seminar by @nadlerlab.bsky.social & Kristin Böhlig! #ChemBio #LipidLove Preregister for free @gfg-chembio.bsky.social

GBM (Gesellschaft für Biochemie und Molekularbiologie)@gbmev.bsky.social · 9mo ago

Join us for the GBM Lunch on January 28 at 12:30 PM (CET)! André Nadler & Kristin Böhlig @nadlerlab.bsky.social (@mpi-cbg.de) will speak on “Quantifying Intracellular Lipid Transport.” Chair: Oliver Thorn-Seshold (TU Dresden) Organizer: Joint Study Group "Chemical Biology" #GBMLunch #ChemicalBiology

Join us for the GBM Lunch on January 28 at 12:30 PM (CET)! André Nadler & Kristin Böhlig @nadlerlab.bsky.social (@mpi-cbg.de) will speak on “Quantifying Intracellular Lipid Transport.” Chair: Oliver Thorn-Seshold (TU Dresden) Organizer: Joint Study Group "Chemical Biology" #GBMLunch #ChemicalBiology

A new paper by @thornsesholdlab.bsky.social reports photoswitchable ligands with wavelength-dependent, and concentration-independent, control of TRPC4/5 channels in live tissues www.nature.com/articles/s41...

Ideal efficacy photoswitching for chromocontrol of TRPC4/5 channel functions in live tissues - Nature Chemical Biology

Using chemical photoswitchable reagents to exert purely wavelength-dependent control over biological systems in deep tissue and in vivo requires a concentration-independent design paradigm. Here, such...

nature.com

Pick a color to control TRP channels - Check out the associated News & Views by Jana Volaric and Wiktor Szymanski on photoswitchable compounds that can agonize or antagonize TRPC4/5 channels depending on the color of light used www.nature.com/articles/s41...

Pick a color to control TRP channels - Nature Chemical Biology

Ideal efficacy photoswitching is introduced as a concept in controlling protein activity with light. Largely independent of the concentration of a light-responsive compound, it enables TRPC4 and TRPC5...

nature.com

Colour me happy!

Nature Chemical Biology@natchembio.nature.com · 9mo ago

A new paper by @thornsesholdlab.bsky.social reports photoswitchable ligands with wavelength-dependent, and concentration-independent, control of TRPC4/5 channels in live tissues www.nature.com/articles/s41...

"It’s also, @georgwinter.bsky.social says, grounds for looking very closely at the proteome-wide effects of any compound in development, no matter its putative mechanism." PREACH #biotech #chemsky

Laurel Oldach@laureloldach.bsky.social · 10mo ago

Biology strikes again: a whole lot of kinase active site inhibitors are also targeted kinase degraders. (Sometimes not even the same kinase!) cen.acs.org/biological-c...

Interesting paper by the groups of @zhizhou1619.bsky.social and Xiang Sheng in @natcomms.nature.com. They developed a system, with which thiophenols can be fed to cells, converted into non-canonical amino acids and used for genetic code expansion in protein engineering.

Design and evolution of artificial enzyme with in-situ biosynthesized non-canonical amino acid

Nature Communications - Enzyme design with non-canonical amino acids has achieved rapid progress in biocatalysis. Here, the authors present an efficient strategy for the design of artificial...

nature.com

Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...

The human UDP-Gal-4-epimerase is important for cellular biosynthesis of UDP-Gal and UDP-GalNAc. Both are important precursors for glycosylation. GALE KO abrogates cellular levels of these metabolites. GALE plays a role in cancer (pubmed.ncbi.nlm.nih.gov/31908526/) - so we decided to drug it!

Video compilation from our #türenauf mit der Maus Tag today! #outreach #chemsky @hhu.de @sophieguti.bsky.social @joguti.bsky.social @markussuta.bsky.social @chemiehhu.bsky.social

What can HaloTag do for you? Triggered fluorogenic labelling? Molecular recording? Photo-Chemically Induced Dimerisation? Philipp Mauker's CHalo motif lets reagents do all three, and more. Read the preprint here - doi.org/10.1101/2025... #chembio #fluorescence #cellbio #SLP