John Ebos
@ebos.bsky.social
Associate Prof. in Cancer Genetics at Roswell Park Comprehensive Cancer Center studying drug resistance, metastasis, the tumor microenvironment, immunecheckpoints, and angiogenesis. https://www.roswellpark.org/research/labs/ebos-lab
Thrilled to share that our paper jitc.bmj.com/content/14/9... ) has just been accepted in the Journal for ImmunoTherapy of Cancer (JITC)! Our key finding: For prostate cancer Immunotherapy, timing may be a game changer!!
Tumor immune microenvironment remodeling predicts response to checkpoi... www.sciencedirect.com/science/arti...
sciencedirect.com
I made a presentation to other faculty about recent progress in general AI, to facilitate the discussion around the impact for research and teaching in biology. It could be that the slides are useful for others trying to do that same. Feel free to re-use. docs.google.com/presentation...
generalAI_for research_intro.pptx
Recent AI developments and what they mean for us Quick primer on general AI models* State-of-the-art in AI agent capabilities AI agents in biology (examples) Discussion - what does this mean for our r...
docs.google.com
A Perspective in Nature Reviews Drug Discovery highlights issues in #AI development for drug discovery, such as inadequate clinical translation focus and challenges with applying AI to life science data, while offering recommendations for improvement. go.nature.com/45Bjpia 🧪
As part of the JCI’s series on The cGAS-STING pathway: DNA sensing in health and disease: Mahajan et al. present: Therapeutic targeting of the cGAS–STING pathway in human disease: doi.org/10.1172/JCI2...
Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences. Our @nature.com article demonstrates that these predictions miss thousands of protein sequences present in human tissues. www.nature.com/articles/s41... 1/
Nikolai Slavov@slavov-n.bsky.social · 2y agoWe report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. www.biorxiv.org/content/10.1...
Thank you to all the organizers at the American Cancer Society Relay for Life event this weekend in Niagara Falls for all of their hard work on behalf of patients to help fund critical cancer research! @americancancersoc.bsky.social @roswellpark.bsky.social secure.acsevents.org/site/STR?pg=...
www.nature.com/articles/s41...
The immunology of human breast cancer - Nature Reviews Immunology
García-Torralba et al. critically discuss key immunobiological features of human breast cancer, focusing on disease heterogeneity and its implications for the development of improved therapeutic optio...
nature.com
Scientific figures can strongly influence how research findings are interpreted. This ‘How to’ Comment article in Nature Human Behaviour outlines a practical strategy for creating figures that communicate clearly across audiences and scientific contexts. go.nature.com/3R00b1t #Academicsky 🧪
The May issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by @jeremynigri.bsky.social, Dave Tuveson, & colleagues showing myofibroblasts induce neuroplasticity to promote pancreatic inflammation & cancer progression. That & more: aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
PD-1 Blockade–Induced DKK1 Expression by CD8+ T Cells Promotes Blood–Brain Barrier Permeabilization
CD8+ T-cell–derived DKK1 mediates anti−PD1-induced opening of the blood–brain barrier, with clinical implications for brain metastasis risk and therapeutic exploitation in the resistant setting.
aacrjournals.org
Distinct Tumor-Immune Ecologies in Patients with Lung Cancer Predict Progression and Define a Clinical Biomarker of Therapy Response
Distinct Tumor-Immune Ecologies in Patients with Lung Cancer Predict Progression and Define a Clinical Biomarker of Therapy Response
AbstractMultiplexed imaging of tissues is an approach that holds promise for improving early detection, diagnosis, and treatment of cancer. In this study, we investigated multiplexed histologic images...
aacrjournals.org
www.nature.com/articles/s41...
Evolutionary characterization of lung cancer metastasis - Nature
DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...
nature.com
Nature research paper: The integrated stress response promotes immune evasion through lipocalin 2 go.nature.com/3MR7cQv
The integrated stress response promotes immune evasion through lipocalin 2 - Nature
The transcription factor ATF4 and its effector lipocalin 2 (LCN2) have a key role in immune evasion and tumour progression, and targeting the ATF4–LCN2 axis might provide a way to treat several types of solid tumour by increasing anti-cancer immunity.
go.nature.com
New FeiginLab paper is OUT! A commonly prescribed anti-anxiety drug reduces inflammatory signaling in pancreatic cancer through regulation of cancer-associated fibroblast activity! aacrjournals.org/cancerrescom...
Alprazolam reduces inflammatory cytokine production in pancreatic cancer-associated fibroblasts
Abstract. Pancreatic ductal adenocarcinoma (PDAC) diagnoses are often accompanied by a number of physical and psychological symptoms, including anxiety and depression. As a result, many patients are p...
aacrjournals.org
Don’t miss our featured posters for Monday, April 20—highlighting even more critical discoveries from Roswell Park. See you at AACR! #AACR26
Repeated cloning cannot be sustained indefinitely in mammals, according to a 20-year study in mice published in Nature Communications. The results suggest that sexual reproduction is necessary to eliminate large-scale genetic mutations that can accumulate in mammalian clones. 🧬 🧪
Limitations of serial cloning in mammals - Nature Communications
Here they show that extended serial somatic cell cloning imposes a threefold increase in de novo mutations compared to natural reproduction, progressively reducing birth rates and ultimately limiting clonal propagation to 58 generations.
go.nature.com
WATCH: Emese Zsiros, MD, PhD, FACOG, of @roswellpark.bsky.social, discusses the @fda.gov approval of pembrolizumab plus paclitaxel with or without pembrolizumab for PD-L1–positive ovarian cancer. #gyncsm #oncology www.onclive.com/view/dr-zsir...
Dr Zsiros on the Use of Pembrolizumab/Paclitaxel/Bevacizumab for Ovarian Cancer | OncLive
Emese Zsiros, MD, PhD, FACOG, discusses the FDA approval of pembrolizumab plus paclitaxel with or without pembrolizumab for PD-L1–positive ovarian cancer.
onclive.com
AI for cancer treatment information: Can academia stay in the game?
AI for cancer treatment information: Can academia stay in the game?
In this issue of Cancer Cell, Jun et al. developed a retrieval-augmented large language model linked to an academia-led molecular knowledge database, demonstrating how AI may deliver cancer treatment information without hallucination. It must compete for adoption amid a fast-paced, industry-led transformation in the flow of clinical information to patients.
dlvr.it
The US slashed research for cancer, Alzheimer’s, mental health — and nearly everything else
Revealed in one chart.
vox.com
Jeremy Berg@jeremymberg.bsky.social · 8mo agoNew research grants in essentially all fields (as judged by NIH Institutes and Center missions) fell by 20-25% from fiscal year 2024 to fiscal year 2025. 2/5
For readers interested in drug repurposing, this review summarizes the approaches, evaluates available in silico resources and presents case studies www.nature.com/articles/s41... rdcu.be/e60em
Thank you to the Sinclair Cancer Research Institute at Queens University for hosting my visit this week. It was fantastic to share our science from Roswell Park and to meet with so many investigators and trainees. @sinclaircri.bsky.social @queensuresearch.bsky.social @roswellpark.bsky.social
Sinclair Cancer Research Institute@sinclaircri.bsky.social · 9mo agoComing soon! Dr. Ebos @ebos.bsky.social will be presenting in our @sinclaircri.bsky.social seminar series on Feb 26 at 4 PM. Questions? Send us an email: scri@queensu.ca #ResearchTalk #SeminarAlert #CancerResearch #CancerDrugResistance @queensuhealth.bsky.social @queensuresearch.bsky.social
Review @natrevdrugdiscov.nature.com Therapeutic targeting of neuroimmune mechanisms in neurodegeneration www.nature.com/articles/s41...
